Host-microbial co-regulation mediates rumen volatile fatty acid production and utilization in dairy cows [0.03%]
宿主微生物共调控乳牛瘤胃挥发性脂肪酸的产生和利用
Wei Wang,Jianrong Ren,Jing Li et al.
Wei Wang et al.
Volatile fatty acids (VFAs) provide more than 70% of the energy source for the ruminants. Understanding the host-microbiota regulation of VFAs production and utilization is highly important for optimizing the feed energy utilization efficie...
Broad synergistic effects of an AMP with multiple antibiotics against drug-resistant bacteria via multifaceted mechanisms [0.03%]
广谱抗菌肽与多种抗生素协同作用对抗耐药菌的多重机制研究
Zifan Ye,Xia Wang,Zhouye Xu et al.
Zifan Ye et al.
Antimicrobial peptides (AMPs) have emerged as promising alternatives or adjuncts to antibiotics. However, most studies on AMP-antibiotic combinations focus on specific drugs or pathogens, with limited exploration of broad-spectrum synergist...
WTAP mediated m6A methylation modulates retinal photoreceptor function via facilitating of REEP6, PDE6B and RDH12 translation [0.03%]
WTAP介导的mRNA m6A甲基化通过促进REEP6、PDE6B和RDH12翻译调节视网膜感光细胞功能
Kuanxiang Sun,Lin Zhang,Wenjing Liu et al.
Kuanxiang Sun et al.
Inherited retinal dystrophies (IRDs) are a leading cause of visual impairment and irreversible blindness worldwide, yet their precise molecular and genetic mechanisms remain unclear. N6-1ent. In the mammalian retina, m6A methylation is wide...
Targeting methionine-induced pyroptosis enhances anti-tumor immunity [0.03%]
靶向甲硫氨酸诱导的细胞焦亡可增强抗肿瘤免疫反应
Mingzhu Lei,Wenying Zhu,Chao Wang et al.
Mingzhu Lei et al.
Pyroptosis is an inflammatory form of programmed cell death that plays a critical role in tumor immunity. However, the metabolic signals involved in this process remain undefined. In the present study, we uncover that methionine metabolism ...
Cell-specific gene expression plasticity in response to hypoxia promotes high-altitude adaptive evolution [0.03%]
缺氧响应的细胞特异性基因表达可塑性促进高原适应性进化
Wen-Tian Wei,Ze Yan,Hui Wu et al.
Wen-Tian Wei et al.
The complex and dynamic relationship between plasticity and genetic adaptation in response to a changing environment represents a longstanding and controversial debate in evolutionary biology. In particular, the molecular and cellular mecha...
Functional traits shape gut microbial assembly beyond phylogeny in estuarine fish [0.03%]
功能特征塑造了河口鱼类肠道微生物汇的构建，而不受系统发育限制的影响
Lei Zhou,Pengfei Wang,Chuanbo Guo et al.
Lei Zhou et al.
Host-specific patterns of symbiotic microbiomes are ubiquitous in nature, yet the intricate interplay among host phylogeny, functional traits, and gut microbiota remains insufficiently explored and debated. In this study, the gut microbiota...
Loss and gain: directing the biosynthesis of metabolites in medicinal plants toward specific targets [0.03%]
得失互换：引领药用植物次级代谢向特定目标转变合成机制研究
Yi-Feng Zhang,Juan Guo
Yi-Feng Zhang
Jiaxin Li,Congying Li,Meijun Wang et al.
Jiaxin Li et al.
Myopia poses a growing global public health challenge, with its underlying mechanisms not yet fully understood. While insufficient daytime light exposure is a recognized protective factor, the role of nighttime light exposure remains conten...
Single-nucleus multi-omics dissection of dysregulated trophoblast development and disrupted immune microenvironment in complete hydatidiform moles [0.03%]
单核多组学解析完全性水泡状胎块滋养细胞发育异常及免疫微环境失调机制
Xueyao Chen,Ruijie Yu,Xiaoyuan Gao et al.
Xueyao Chen et al.
Hydatidiform mole (HM) is driven by aberrant trophoblast proliferation, disrupting embryonic development and leading to pregnancy loss with increased risk of malignant progression. Despite its clinical significance, the cellular and molecul...
Expanding the sensory horizon: chemosensory receptors beyond traditional olfactory and taste organs in insects [0.03%]
扩展感官视野：昆虫传统嗅觉和味觉器官以外的化学感觉受体
Sai Zhang,Guirong Wang,Emmanuelle Jacquin-Joly
Sai Zhang
Chemosensation is crucial for insects, governing essential behaviors like foraging, mating, predator avoidance, and habitat selection. Traditionally, research has focused on chemosensory receptors-specifically odorant receptors and gustator...