Direct analysis of transcription factor protected cfDNA in plasma by ChIP-seq: measurement of altered CTCF binding in cancer is a novel biomarker for liquid biopsy [0.03%]
直接通过ChIP-seq分析血浆中转录因子保护的cfDNA：癌变改变CTCF结合位点为液体活检新的生物标志物
Dorian Pamart,Brieuc Cuvelier,Adrien Govaerts et al.
Dorian Pamart et al.
Background: The aggregate presence of cell free CTCF-DNA (cfCTCF-DNA) nucleoproteins in plasma has been reported. But the occupancy of individual CTCF binding sites in plasma cfCTCF-DNA has not been studied. ...
Inflammation mediates the Pace of aging based on DNA methylation on mortality from NHANES 1999-2002: a national prospective cohort study [0.03%]
基于DNA甲基化率的NHANES(1999-2002)全国前瞻性队列研究：炎症介导了衰老速度对死亡率的影响
Jihua Feng,Yuting Liang,Jie Zhou et al.
Jihua Feng et al.
Background: Global population aging underscores the urgent need for biomarkers quantifying biological aging trajectories. While DNA methylation-derived pace of aging (DunedinPoAm) measures individual differences, its gene...
Biological age acceleration and bradyarrhythmia: evidence from clinical and epigenetic perspectives [0.03%]
从临床和表观遗传学角度探讨生物衰老与心动过缓的关系
Zheng-Qi Song,Lu-Jie Huang,Ke Liu et al.
Zheng-Qi Song et al.
Background: To date, effective preventive and therapeutic strategies for early-stage bradyarrhythmia remain limited. Methods: We first ...
Aging-driven transcriptional programs in diabetic kidney disease: multi-omics discovery of diagnostic biomarkers and drug-repurposing targets [0.03%]
糖尿病肾病中衰老驱动的转录程序：诊断生物标志物和老药新用靶点的多组学发现
Xue Hu,Yingzhuo Li,Yang Wang et al.
Xue Hu et al.
Background: Diabetic kidney disease (DKD) is the primary global cause of end-stage renal disease. However, the aging-related gene networks driving its progression remain unclear. ...
Meike Bartels,Margot P van de Weijer,Natalia Azcona-Granada et al.
Meike Bartels et al.
Wellbeing is associated with both behavioral phenotypes as well as several key life outcomes, such as health, employment, and coping with stressful events. These phenotypes associated with wellbeing could be potential indicators of differen...
The glycolysis-H4K12la-PKM2 positive feedback loop drives M2 polarization of macrophages in colorectal cancer [0.03%]
糖酵解-H4K12乙酰化-PKM2正反馈环驱动结直肠癌中巨噬细胞M2极化
Zhuo Zhang,Qiaoling Peng,Shaohu Wang et al.
Zhuo Zhang et al.
Background: Despite the dominance of M2-polarized tumor-associated macrophages in colorectal cancer (CRC), the metabolic-epigenetic mechanisms by which CRC cells sustain this immunosuppressive phenotype remain elusive. We...
Correction: GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer [0.03%]
纠正：GLYATL1与代谢和表观遗传改变以及内分泌耐药性在腔内乳腺癌中的关联
Janina Müller,Emre Sofyali,Luisa Schwarzmüller et al.
Janina Müller et al.
Published Erratum
Clinical epigenetics. 2026 Jul 10;18(1):136. DOI:10.1186/s13148-026-02203-z 2026
Preliminary study on PAX1/JAM3 methylation and HPV viral load in CIN3-like squamous cell carcinoma: Are there differences from CIN3 and early invasive carcinoma? [0.03%]
PAX1/JAM3甲基化和HPV病毒载量在CIN3样鳞状细胞癌中的初步研究：与CIN3和早期浸润性癌不同吗？
Mingzhu Li,Xiaobo Zhang,Xing Zhao et al.
Mingzhu Li et al.
Objective: Cervical intraepithelial neoplasia grade 3 (CIN 3)-like squamous cell carcinoma (SCC) is a recently identified subtype of cervical cancer with a deceptive growth pattern. It mimics the phenotype of CIN 3, invol...
Tumor-type specific methylation patterns of MTAP in human samples and cell lines [0.03%]
人样本和细胞系中MTAP的肿瘤类型特异性甲基化模式
Luis Álvarez-Carrión,Dalma Müller,Manuel Pedregal et al.
Luis Álvarez-Carrión et al.
Loss of methylthioadenosine phosphorylase creates a therapeutically dependency on PRMT5, yet current strategies select patients based only on MTAP genomic deletion. We performed an integrated analysis of DNA methylation and gene expression ...
Epigenetic editing approaches maturity: AI-driven precision design, delivery innovation, and the road to clinical translation [0.03%]
表观遗传编辑走向成熟：AI驱动的精准设计、递送创新及临床转化之路
Shiqi Chang,Di Lu,Yuyuan Jin et al.
Shiqi Chang et al.
Epigenetic editing achieves durable gene silencing through targeted modification of chromatin and DNA methylation states without altering the genomic sequence-modifications that remain fundamentally reversible compared with genome editing. ...