Epigenetic-Metabolic interplay in chronic kidney disease mortality: insights from grimage acceleration and transcriptomic profiling [0.03%]
表观遗传-代谢互作与慢性肾脏病死亡率的关系：来源于影像加速和转录组学分析的启示
Xiangyun Dang,Zhongxin Jin,Yafeng Zhao et al.
Xiangyun Dang et al.
Background: Chronic kidney disease (CKD) is associated with a substantially elevated risk of mortality. Although GrimAge acceleration (GAA) and metabolic syndrome (MetS) are both implicated in this risk, their combined im...
A visual analysis of the research dynamics of biomarkers for lung cancer screening [0.03%]
肺癌筛查生物标志物研究动态的可视化分析
Huange Zhu,Burong Li,Ranran Kong et al.
Huange Zhu et al.
Background: Non-invasive biomarkers offer potential to improve risk stratification and early diagnosis of lung cancer, complementing low-dose computed tomography (LDCT) screening. This study employed bibliometric analysis...
Epigenetic ageing during the COVID-19 pandemic: global age acceleration, independent of SARS-CoV-2 infection [0.03%]
新冠疫情下的表观遗传衰老：全球年龄加速，独立于SARS-CoV-2感染
Christopher J Shore,Marc F Österdahl,Nicholas R Harvey et al.
Christopher J Shore et al.
Introduction: The COVID-19 pandemic had profound effects for both infected and uninfected individuals. We aimed to identify acute and chronic epigenetic alterations from SARS-CoV-2 infection and/or lockdown measures. ...
DNA methylation profiling in Huntington's disease reveals disease associated changes in the striatum [0.03%]
亨廷顿舞蹈病的DNA甲基化谱分析发现纹状体与疾病相关的改变
Gregory Wheildon,Adam R Smith,Luke Weymouth et al.
Gregory Wheildon et al.
Background: Huntington's disease is caused by a trinucleotide CAG repeat expansion in the HTT gene. Despite displaying autosomal dominance, phenotypic variation exists amongst mutation carriers, in particular relating to ...
Arecoline-induced EV-mediated ZNF582 hypermethylation drives IFIT1-PD-L1 immune evasion in oral squamous cell carcinoma [0.03%]
Arecoline诱导的EV介导的ZNF582高甲基化驱动IFIT1-PD-L1在口腔鳞状细胞癌中的免疫逃逸
Hui-Hsin Ko,Hsin-Hui Peng,Chun-Pin Chiang et al.
Hui-Hsin Ko et al.
Background: This study examined the role of arecoline-induced zinc finger protein 582 (ZNF582) methylation via extracellular vesicles (EVs) in oral squamous cell carcinoma (OSCC) and its effect on PD-L1 expression through...
DNA demethylation of ANXA4 is associated with atrial fibrillation risk through myeloid immune mechanisms: evidence from Mendelian randomization and multi-omics analyses [0.03%]
ANXA4的DNA去甲基化通过髓系免疫机制与房颤风险相关性研究：来自孟德尔随机和多组学分析的证据
Qingyi Zeng,Jingjing Xiang,Yilan Li et al.
Qingyi Zeng et al.
Background: Atrial fibrillation (AF) is a common arrhythmia affecting millions of patients globally. While epigenetic modifications play a significant role in cardiovascular diseases, their contribution to AF remains inco...
Epigenome-wide DNA methylation and spontaneous preterm birth among pregnant black women [0.03%]
黑人孕妇全表观基因组DNA甲基化和自发性早产
Tingting Zhao,Yihong Zhao,Paolo Reho et al.
Tingting Zhao et al.
Background: Preterm birth (PTB, < 37 weeks of gestation) is a major public health concern in the United States, with Black women experiencing a higher incidence compared to White women. Although some studies have identifi...
Early detection of gastric cancer with the assistance of cell-free DNA fragmentomics [0.03%]
借助于细胞游离DNA片段组学的胃癌早期检测技术
Xiaoli Huang,Zhengxiang Han,Ying Zhang et al.
Xiaoli Huang et al.
Background: Gastric cancer remains one of the most prevalent malignancies globally. As early-stage gastric cancer is typically asymptomatic or presents with non-specific symptoms, most patients are diagnosed at advanced s...
Accelerated biological aging and underlying epigenetic modification mediated the association between obesity and asthma [0.03%]
肥胖与哮喘关系的中介效应或由加速的生物衰老及其潜在的表观遗传学改变介导
Jian Liu,Zhengqi Song,Chengge Shi et al.
Jian Liu et al.
Background: The relationships among obesity, accelerated biological aging, and asthma, as well as the underlying epigenetic mechanisms, remain incompletely understood. ...
Histone H3K27 demethylation drives Crohn's disease inflammation: GSK-J4 as a potential epigenetic therapy [0.03%]
组蛋白H3K27去甲基化驱动克罗恩病炎症：GSK-J4作为潜在表观遗传学疗法
Jigisha A Patel,Kevin Beatson,Jeries Abu-Hanna et al.
Jigisha A Patel et al.
Background: Crohn's disease (CD) is characterised by recurrent gastrointestinal inflammation. Epigenetic modifications, particularly the methylation of histone H3 at lysine 27 trimethylation (H3K27me3), are crucial in reg...