Models and Mechanisms of Acquired Antihormone Resistance in Breast Cancer: Significant Clinical Progress Despite Limitations [0.03%]
乳腺癌获得性抗激素耐药的模型与机制：尽管存在局限性但仍取得显著临床进展
Elizabeth E Sweeney,Russell E McDaniel,Philipp Y Maximov et al.
Elizabeth E Sweeney et al.
Translational research for the treatment and prevention of breast cancer depends upon the four Ms: models, molecules, and mechanisms in order to create medicines. The process, to target the estrogen receptor (ER) in estrogen-dependent breas...
Lack of substrate inhibition in a monomeric form of human cytosolic SULT2A1 [0.03%]
人胞质SULT2A1单体形式缺乏底物抑制作用
Ian T Cook,Thomas S Leyh,Susan A Kadlubar et al.
Ian T Cook et al.
Mammalian cytosolic sulfotransferases (SULTs) frequently show substrate inhibition during the sulfation of increasing concentrations of substrates. SULT2A1, a major human liver isoform responsible for the conjugation of hydroxysteroids, bil...
Structural rearrangement of SULT2A1: effects on dehydroepiandrosterone and raloxifene sulfation [0.03%]
人SULT2A1酶的结构重组及其对静激素和雷洛昔芬硫酸化的影响研究
Ian T Cook,Thomas S Leyh,Susan A Kadlubar et al.
Ian T Cook et al.
BACKGROUND: Human cytosoloic sulfotransferase (SULT) 2A1 is a major hepatic isoform and sulfates hydroxyl groups in structurally diverse sterols and xenobiotics. SULT2A1 crystal structures resolved in the presence and absence of 3',5'-dipho...
Exposure to the Endocrine Disruptor Bisphenol A Alters Susceptibility for Mammary Cancer [0.03%]
暴露于内分泌干扰物双酚A改变乳腺癌的易感性
Coral A Lamartiniere,Sarah Jenkins,Angela M Betancourt et al.
Coral A Lamartiniere et al.
Bisphenol A (BPA) is a synthetically made chemical used in the production of polycarbonate plastics and epoxy resins. Recent studies have shown over ninety percent of humans investigated have detectable BPA concentrations. Yet, the biggest ...
The Conformation of the Estrogen Receptor Directs Estrogen-Induced Apoptosis in Breast Cancer: A Hypothesis [0.03%]
雌激素受体构象决定乳腺癌细胞的凋亡：一种假说
Philipp Maximov,Surojeet Sengupta,Joan S Lewis-Wambi et al.
Philipp Maximov et al.
BACKGROUND: Estrogens are classified as type I (planar) and type II (angular) based on their structures. In this study we have used triphenylethylenes (TPEs) compounds related to 4OHT to address the hypothesis that the conformation of the l...
Adrenaline: communication by electron emission. Effect of concentration and temperature. Product analysis [0.03%]
肾上腺素：由电子发射进行通讯。浓度和温度的影响。产物分析
Nikola Getoff,C Huber,J Hartmann et al.
Nikola Getoff et al.
BACKGROUND: Based on the recent findings about the ability of sexual hormones to emit electrons (e(aq) (-)) and to act as electron mediator, it was of interest to investigate adrenaline as an important neurotransmitter. MATERIALS AND METHOD...
Estrogen regulation of X-box binding protein-1 and its role in estrogen induced growth of breast and endometrial cancer cells [0.03%]
雌激素对X盒结合蛋白-1的调节及其在雌激素诱导的乳腺癌和子宫内膜癌细胞增殖中的作用
Surojeet Sengupta,Catherine G N Sharma,V Craig Jordan
Surojeet Sengupta
BACKGROUND: X-box binding protein 1 (XBP1), a transcription factor involved in unfolded protein response, is also an estrogen-regulated gene and strongly correlates with estrogen receptor alpha (ERα) expression in breast cancers. We invest...
Estrogen induced breast cancer is the result in the disruption of the asymmetric cell division of the stem cell [0.03%]
雌激素诱导的乳腺癌是干细胞不对称分裂破坏的结果
Jose Russo,Kara Snider,Julia S Pereira et al.
Jose Russo et al.
There is evidence that in the human breast there is a stem cell population that can give rise to many different cell types and have the unique potential to divide asymmetrically. In this way stem cells maintain the stem cell pool and simult...