Structure activity relationship-guided scaffold hopping for identification of novel thiadiazole derivatives as potent SARS-CoV-2 Mpro inhibitors [0.03%]
基于结构活性关系的支架跳跃发现新的噻二唑衍生物作为SARS-CoV-2 Mpro抑制剂
Maher S Alwethaynani,Khaled Alzhrani,Hina Sarfraz et al.
Maher S Alwethaynani et al.
The ongoing COVID-19 pandemic has presented enormous challenges to worldwide healthcare systems, and effective therapeutic strategies must accompany mass vaccination efforts. In this context, Mpro (the main protease of SARS-CoV-2) is arguab...
Monoterpene-indole alkaloid from Rinorea yaundensis and antidiabetic potential of its hydrochloride [0.03%]
Rinorea yaundensis中生物碱的分离及其盐酸盐化合物的抗糖尿病活性研究
Bushra Khatoon,Muhammad Kawish,Hina Zahid et al.
Bushra Khatoon et al.
Chromatographic resolutions of methanolic extract of the aerial parts of Rinorea yaundensis led to the isolation of a new monoterpene indole alkaloid yaundentine 1, along with its previously reported hydrochloride 2 and sarpagine 3, respect...
Calofrasolide A, a new pyranocoumarin from the stem bark of Calophyllum fraseri M.R.Hend. & Wyatt-Sm. and their antimicrobial and antibiofilm activities [0.03%]
来源于Calophyllum fraseri M.R.Hend. & Wyatt-Sm.的新吡喃香豆素Calofrasolide A及其抗菌和抗生物膜活性
Nur Nabilah Mohd Zaini,Wan Mohd Nuzul Hakimi Wan Salleh,Nurunajah Ab Ghani et al.
Nur Nabilah Mohd Zaini et al.
A new pyranocoumarin, Calofrasolide A (1), was isolated from the stem bark of Calophyllum fraseri, together with the known constituents β-sitosterol, stigmasterol, friedelin, and lupeol. The structure of the new compound was established th...
Elucidating the biodegradation potential of Nudix hydrolase from Bacillus paranthracis via different approaches [0.03%]
通过不同方法阐明Bacillus paranthracis Nudix酶的生物降解潜力
Muhammad Naveed,Nimra Hanif,Minahil Zahid et al.
Muhammad Naveed et al.
The Nudix hydrolase from Bacillus paranthracis MBBL1 was investigated using in silico approaches. Polyfluoroalkyl substances (PFAS) are persistent environmental contaminants associated with serious health and ecological risks because of the...
Synthesis and characterization of zinc oxide nanoparticles by the aerial part of Artemisia roxburghiana extract and assessment of their biological activities [0.03%]
通过艾纳香叶提取物合成并表征锌纳米颗粒及其生物活性评估
Ruchika Sharma,Ghazala Shaheen,Indra Rautela et al.
Ruchika Sharma et al.
The zinc oxide nanoparticle (ZnONPs) used in this study were synthesized using Artemisia roxburghiana extract (aerial part). The absorption peak at 353 nm in UV spectroscopy indicates the production of zinc oxide nanoparticles. The synthesi...
Phytochemical and antibacterial studies of the ethanolic stem barks extract of Anthocleista vogelii planch, and the in silico study of its secondary metabolites on two bacteria strains Staphylococcus aureus and Salmonella typhi [0.03%]
Anthocleista vogelii Planch.茎皮乙醇提取物的植化和抗菌研究及其次生代谢产物对金黄色葡萄球菌和伤寒沙门氏菌的体外分子对接研究
Tengu Awazi,Judith Caroline Ngo Nyobe,Baruch Ateba Amana et al.
Tengu Awazi et al.
This study investigates the phytochemical composition, antibacterial efficacy, and molecular interactions of Anthocleista vogelii stem barks extracts. Phytochemical screening revealed the presence of flavonoids, alkaloids, triterpenes, phen...
Antiplasmodial and cytotoxic activities of secondary metabolites from the leaves of Pleiocarpa bicarpellata Stapf (Apocynaceae) [0.03%]
Pleiocarpa bicarpellata Stapf (夹竹桃科)的叶子中的次生代谢产物的抗疟和细胞毒性作用
Aurore M Bella,Guy R Ebede,Gaetan B N Bayiha et al.
Aurore M Bella et al.
Phytochemical studies of the leaves of Pleiocarpa bicarpellata led to the isolation of a new indole C-glycoside, Bicarpellatoside A (1), along with eight known compounds (2-9), including three indoles, two indolines, an iridoid monoterpenoi...
Structure-based drug discovery targeting fmhA in Staphylococcus warneri using extracts of Calliandra harrisii: an integrated ethnobotanical and in silico approach [0.03%]
基于结构的药物发现：利用Calliandra harrisii提取物针对Staphylococcus warneri中的fmhA进行靶向：一种整合民族植物学和计算方法的方法
Nouman Ali,Muhammad Naveed,Muhammad Waseem et al.
Nouman Ali et al.
Staphylococcus warneri is a Gram-positive bacterium increasingly associated with urinary tract and skin infections and shows emerging multidrug resistance. In this study, S. warneri was cultured, and the virulence-associated fmhA gene was a...
Chemical composition and in vitro antifungal activity of essential oils from the fruits of Schinus molle L. (Anacardiaceae) [0.03%]
Schinus molle L. (安息香科)果实精油的化学成分及体外抗真菌活性
Isabela Maria Grossi Leal,Chrystiaine Helena Campos de Matos,Marcelo Henrique Reis Carvalho et al.
Isabela Maria Grossi Leal et al.
This study explored the chemical composition and antifungal properties of the essential oil extracted from the fruits of Schinus molle L. (Anacardiaceae), focusing on its activity against Colletotrichum gloeosporioides, a phytopathogenic fu...
Formulation of pullulan-assisted nanoparticles for improved dasatinib cytotoxicity in A549 lung carcinoma cells [0.03%]
辅剂普兰兰纳米颗粒的合成用于提高Dasatinib在A549肺癌细胞中的细胞毒性
Sunita S Shinde,Aishwarya A Lohar,Avinash H Hosmani et al.
Sunita S Shinde et al.
Dasatinib (DAS) exhibits therapeutic potential for the treatment of lung cancer. However, its clinical utility is marred owing to poor solubility, low oral bioavailability, and rapid systemic clearance. Therefore, the current investigation ...