Primary pulmonary presentation extranodal NK/T-cell lymphoma, small cell variant, illustrating the value of flow EBER in situ hybridisation assay [0.03%]
以原发肺表现为主的NK/T细胞淋巴瘤小细胞变异型及流式EBER原位杂交检测的价值
Soham Kale,Zbigniew Rudzki,Bernard Maybury et al.
Soham Kale et al.
A 57-year-old male from Guinea presented with 6 months of progressive shortness of breath, productive cough, and occasional night sweats. A lung biopsy revealed an angiocentric pulmonary infiltrate of small bland lymphocytes and lymphoepith...
Leukemic presentation of ALK-positive anaplastic large cell lymphoma in an adult patient with hemophagocytic lymphohistiocytosis [0.03%]
成人霍奇金淋巴细胞增生性噬血细胞综合征伴ROS阳性ALK淋巴瘤的白血病表现
Mark Oliver,Jenny Byrd,Eduard Matkovic
Mark Oliver
Systemic ALK + anaplastic large cell lymphoma (ALCL) is a CD30-positive T cell neoplasm that commonly affects lymph nodes with frequent involvement of extranodal sites. A leukemic phase with peripheral blood involvement is extremely rare, a...
HIV-negative KSHV/HHV8-associated multicentric Castleman disease with concurrent Kaposi sarcoma and POEMS-like manifestations [0.03%]
HHV-8阳性非艾滋病多中心型Castleman病合并卡波西肉瘤及POEMS综合征样表现
Gökhan Burul,Büşra Tuğçe Tonyalı,İsa Yalçınkaya et al.
Gökhan Burul et al.
Introduction: Castleman disease (CD) is a heterogeneous lymphoproliferative disorder with unicentric and multicentric forms. Multicentric CD (MCD) is etiologically classified into idiopathic MCD (iMCD), POEMS-associated M...
Auer rod-like inclusions in marginal zone lymphoma: a potential diagnostic pitfall [0.03%]
边缘区淋巴瘤中的Auer小体样包涵体：潜在的诊断陷阱
Nour Louati,Imen Krichen,Ines Jedidi et al.
Nour Louati et al.
A 47-year-old man presented with leukocytosis and absolute lymphocytosis. Peripheral blood smear examination revealed atypical lymphoid cells containing striking Auer rod-like cytoplasmic inclusions, creating a strong morphologic impression...
CD5+ CD10+ lymphoplasmacytic lymphoma with cutaneous histologic transformation in a post-transplant setting [0.03%]
移植后发生皮肤组织学转化的CD5+ CD10+淋巴浆细胞样淋巴瘤病例报告
Michael T Mulvena Jr,Sam Sadigh,Eric D Jacobsen et al.
Michael T Mulvena Jr et al.
Lymphoplasmacytic lymphoma (LPL) is a lymphoproliferative neoplasm characterized by small plasmacytic cells infiltrating the bone marrow and is typically associated with IgM paraprotein detection. In rare cases, LPL may undergo histologic t...
A case of true acute eosinophilic leukemia arising from myelodysplastic syndrome [0.03%]
一例由骨髓增生异常综合征转化而来的真性急性嗜酸性粒细胞白血病病例报告
Qingyu Li,Matthew S Alkaitis,William Shomali et al.
Qingyu Li et al.
Acute leukemias of the myeloid lineage most commonly show myeloid and/or monocytic differentiation. Leukemias with erythroid, megakaryoblastic, and basophilic differentiation are more rare but are well documented. In contrast, acute leukemi...
Diagnostic pitfalls and molecular insights in a rare RUNX1::TACC1-positive AML with t(8;21)(p11;q22) [0.03%]
罕见RUNX1::TACC1阳性伴t(8;21)(p11;q22)的AML的诊断陷阱和分子见解
Shanshan Sun,Zhi Wang,Long Chen et al.
Shanshan Sun et al.
The transforming acidic coiled-coil containing protein 1 (TACC1) gene is a recognized oncogenic driver in solid tumors through FGFR1::TACC1 fusions, but remains extremely rare in acute myeloid leukemia (AML), with only one prior case of RUN...
Utility of MEF2B immunohistochemistry in distinguishing follicular lymphoma and marginal zone lymphoma in diagnostically challenging cases [0.03%]
MEF2B免疫组化在诊断困难的情况下区分滤泡性淋巴瘤和边缘区淋巴瘤的价值
Joanna C Dalland,Oluwayomi S Oyedeji,David S Viswanatha et al.
Joanna C Dalland et al.
Background: Distinguishing follicular lymphoma (FL) from marginal zone lymphoma (MZL) can be challenging, as the morphology and immunophenotype can overlap particularly in cases with marginal zone differentiation (MZD). M...
Unexpected melanoma metastasis with E-cadherin expression in bone marrow [0.03%]
骨髓中出现意外的E-钙黏蛋白阳性黑色素瘤转移病灶
Marco Pocci
Marco Pocci
Finding an unexpected metastatic lesion in bone marrow biopsy (BMB) performed for a hematological indication can cause diagnostic issues. In a BMB performed in a patient with suspected acute leukemia evolved from a post-essential thrombocyt...
Spatially segregated B- and T-lymphoblasts in mixed-phenotype acute leukemia with BCR::ABL1 [0.03%]
BCR::ABL1阳性混合表型急性白血病中空间分离的B淋巴细胞和T淋巴细胞.BLASTS
Ingrid S Tam,José-Mario Capo-Chichi,Adam C Smith et al.
Ingrid S Tam et al.
Background: Mixed phenotype acute leukemias (MPALs) account for approximately 2-5% of acute leukemias. Purpose: We report a case of MPA...