Neurogenic Cell Behavior in 3D Culture Enhanced Within a Highly Compliant Synthetic Hydrogel Platform Formed via Competitive Crosslinking [0.03%]
通过竞争性交联形成的高度顺应性的合成水凝胶平台中增强的神经源性细胞行为研究
Rachel Chapla,Rachel R Katz,Jennifer L West
Rachel Chapla
Purpose: Scaffold materials that better support neurogenesis are still needed to improve cell therapy outcomes for neural tissue damage. We have used a modularly tunable, highly compliant, degradable hydrogel to explore t...
Trisomy 21 Alters Cell Proliferation and Migration of iPSC-Derived Cardiomyocytes on Type VI Collagen [0.03%]
21三体通过VI型胶原改变诱导性多能干细胞衍生的心肌细胞的增殖和迁移
Rachel S Reeser,Alyssa K Salazar,Kendra M Prutton et al.
Rachel S Reeser et al.
Purpose: Individuals with Down syndrome (DS) are 2000 times more likely to develop a congenital heart defect (CHD) than the typical population Freeman et al. in Am J Med Genet 80:213-217 (1998). The majority of CHDs in in...
Investigating the Influence of Heterogeneity Within Cell Types on Microvessel Network Transport [0.03%]
探究细胞类型内的异质性对微血管网络运输的影响
Junyu Nan,Sayan Roychowdhury,Amanda Randles
Junyu Nan
Background: Current research on the biophysics of circulating tumor cells often overlooks the heterogeneity of cell populations, focusing instead on average cellular properties. This study aims to address the gap by consi...
Alisa Morss Clyne,Owen J T McCarty,Michael R King
Alisa Morss Clyne
Single-Cell Proliferation Microfluidic Device for High Throughput Investigation of Replicative Potential and Drug Resistance of Cancer Cells [0.03%]
一种用于高通量研究癌细胞增殖潜力和耐药性的单细胞增殖微流控装置
Adity A Pore,Nabiollah Kamyabi,Swastika S Bithi et al.
Adity A Pore et al.
Introduction: Cell proliferation represents a major hallmark of cancer biology, and manifests itself in the assessment of tumor growth, drug resistance and metastasis. Tracking cell proliferation or cell fate at the singl...
Head-to-Head Comparison of CCN4, DNMT3A, PTPN11, and SPARC as Suppressors of Anti-tumor Immunity [0.03%]
CCN4、DNMT3A、PTPN11和SPARC抑制抗肿瘤免疫的直接比较研究
Anika C Pirkey,Wentao Deng,Danielle Norman et al.
Anika C Pirkey et al.
Purpose: Emergent cancer cells likely secrete factors that inhibit anti-tumor immunity. To identify such factors, we applied a functional assay with proteomics to an immunotherapy resistant syngeneic mouse melanoma model....
Nuclear Entry of DNA and Transgene Expression in Dividing and Non-dividing Cells [0.03%]
分裂与不分裂细胞中的DNA输入和转基因表达
Justin Sylvers,Yifei Wang,Fan Yuan
Justin Sylvers
Introduction: Plasmid DNA (pDNA) must be delivered into the nucleus for transgene expression in mammalian cells. The entry may happen passively during the nuclear envelope breakdown and reformation in dividing cells or ac...
The Effect of Substrate Stiffness on Elastic Force Transmission in the Epithelial Monolayers over Short Timescales [0.03%]
基质刚度对上皮单层短时间尺度下弹性力传输的影响
Aapo Tervonen,Sanna Korpela,Soile Nymark et al.
Aapo Tervonen et al.
Purpose: The importance of mechanical forces and microenvironment in guiding cellular behavior has been widely accepted. Together with the extracellular matrix (ECM), epithelial cells form a highly connected mechanical sy...
FUNCTIONAL COUPLING OF VALVULAR INTERSTITIAL CELLS AND COLLAGEN VIA α2β1 INTEGRINS IN THE MITRAL LEAFLET [0.03%]
二联征心内膜心肌纤维化症患者左室流出道梗阻的机制研究
Elizabeth H Stephens,Christopher A Durst,Julia C Swanson et al.
Elizabeth H Stephens et al.
Once considered passive flaps, we now understand that mitral leaflets are dynamic structures with their own vasculature and innervation that actively remodel and even generate force in response to their environments. Valvular interstitial c...
Peristalsis-Associated Mechanotransduction Drives Malignant Progression of Colorectal Cancer [0.03%]
蠕动相关的机械转导驱动结直肠癌恶性进展
Abigail J Clevenger,Maygan K McFarlin,Claudia A Collier et al.
Abigail J Clevenger et al.
Introduction: In the colorectal cancer (CRC) tumor microenvironment, cancerous and precancerous cells continuously experience mechanical forces associated with peristalsis. Given that mechanical forces like shear stress a...