Mechanisms and Strategies for Enhancing DNA Nuclear Entry in Gene Delivery [0.03%]
增强基因传递中DNA核输入的机制和策略
Justin Sylvers,Fan Yuan
Justin Sylvers
Background: Nonviral gene delivery using DNA vectors is widely used in cell engineering, vaccination, and gene therapy, but delivery efficiency remains lower than those of viral vectors and mRNA-based approaches, partly d...
Cell-Extracellular Matrix Feedback Results in Spontaneous Cell Polarization and Heterogeneous Remodeling in 3D Isotropic and Aligned Discrete-Fiber Models of Cell-Mediated Remodeling [0.03%]
细胞-细胞外基质反馈导致自发的细胞极化和三维等轴及定向离散纤维模型中介导的重构中的异质性
Adam W Y Ley,Lauren M Bersie-Larson,Sabin Adhikari et al.
Adam W Y Ley et al.
Purpose: The extracellular matrix (ECM) is a dynamic fiber environment containing structural information that significantly impacts cell behavior. Recent experimental work has demonstrated that cells also have significant...
Non-linear Characterization of Commercial and Decellularized Hydrogels: Statistical Framework Enhanced by Bayesian Optimization [0.03%]
商业和脱细胞水凝胶的非线性特征：贝叶斯优化增强的统计框架
D E García-García,D Marques,H Amaveda et al.
D E García-García et al.
Scope: Hydrogels are widely used in the design of tissue substitutes because of their ability to mimic the extracellular matrix (ECM). Their mechanical cues critically influence the cellular response, making accurate char...
Decoupling Mechanical Confinement and Fibrotic Extracellular Matrix Signaling in Vestibular Schwannoma Using Tunable 3D Hydrogels [0.03%]
使用可调3D水凝胶解耦听神经鞘瘤中的机械约束和纤维化细胞外基质信号转导
Melanie Fisher,Han Tn Nguyen,Rinky Ghosh et al.
Melanie Fisher et al.
Purpose: Vestibular schwannoma (VS) progressively stiffens and remodels its extracellular matrix (ECM) during growth. However, how mechanical confinement and adhesive ECM signaling regulate schwannoma behavior in vitro re...
Tuning Hydrogel Mechanics and Microstructure to Maximize Extracellular Vesicle Production from Mesenchymal Stem Cells [0.03%]
调节水凝胶力学性能和微观结构以最大化间充质干细胞产生的细胞外囊泡数量
Riddhesh B Doshi,Bethany Yee,Nicolas Warburton et al.
Riddhesh B Doshi et al.
Background: The secretory output from mesenchymal stem cells (MSCs) have emerged as promising therapeutics with extracellular vesicles (EVs) gaining prominence due to solution stability and optimal size for overcoming bio...
Extracellular Vesicles (EVs) Mirror Their Source: Comparative Analysis of Bone Marrow-Derived and Adipose-Derived Stem Cells and EVs in Bone Regeneration [0.03%]
外泌体与其来源相呼应：骨髓来源和脂肪组织来源干细胞及外泌体在骨再生中的比较分析研究
Chun-Yee Ho,Shih-Hsuan Mao,Chia-Hsuan Tsai et al.
Chun-Yee Ho et al.
Background: Critical-sized craniofacial defects pose a significant clinical challenge, prompting the investigation of novel regenerative strategies. While mesenchymal stem cells (MSCs) and extracellular vesicles (EVs) hol...
Neonatal and Adult Dermal Fibroblasts Remodel Hyaluronan Enriched Pericellular Matrix Differentially in Hyaluronic Acid Binding Peptide-Tethered Collagen Hydrogels [0.03%]
富透明质酸肽修饰的胶原水凝胶中成年和新生儿皮肤纤维母细胞对富含透明质酸的细胞外基质重塑行为不同
Vanessa Christine Smith,Whitney Ann Ponwith,Steve Smith et al.
Vanessa Christine Smith et al.
Purpose: The goal of this study was to evaluate the impact of hyaluronic acid binding peptide (HABP) on pericellular matrix remodeling and to determine whether this effect differs between adult and neonatal fibroblasts. N...
Sudipta Chowdhury,Prabir Patra,Michael R King et al.
Sudipta Chowdhury et al.
Mechanical Forces and the Nucleolus: A New Frontier in Cellular Mechanotransduction [0.03%]
机械力与核仁：细胞力学信号转导的新前沿
Fatima Shaalan,Fatima Kdouh,Zahraa Salhab et al.
Fatima Shaalan et al.
The nucleolus, traditionally viewed as the site of ribosome biogenesis, is now recognized as a multifunctional organelle involved in stress sensing, genome regulation, and cellular homeostasis. In parallel, mechanical cues arising from neig...
The Synergistic Regulation of Lung Cancer Cell Migration by Tensile Stress and Matrix Stiffness [0.03%]
拉伸应力和基质刚度对肺癌细胞迁移的协同调节作用
Yii-Chun Chen,Shuai Shao,Xiaohui Yu et al.
Yii-Chun Chen et al.
Purpose: To investigate the synergistic effects of matrix stiffness and cyclic tensile stress-key mechanical cues in the lung tumor microenvironment-on lung cancer cell migration, and to elucidate the underlying mechanotr...