Three-Dimensional Tumor Models to Study Cancer Stemness-Mediated Drug Resistance [0.03%]
三维肿瘤模型研究癌症干细胞介导的药物抗性
Astha Lamichhane,Hossein Tavana
Astha Lamichhane
Solid tumors often contain genetically different populations of cancer cells, stromal cells, various structural and soluble proteins, and other soluble signaling molecules. The American Cancer society estimated 1,958,310 new cancer cases an...
Aleksandra K Denisin,Honesty Kim,Ingmar H Riedel-Kruse et al.
Aleksandra K Denisin et al.
Introduction: Traction force microscopy (TFM) is a widely used technique to measure cell contractility on compliant substrates that mimic the stiffness of human tissues. For every step in a TFM workflow, users make choice...
Ping Xie
Ping Xie
Introduction: Kinesin-3 motor, which is in the monomeric and inactive form in solution, after cargo-induced dimerization can step on microtubules towards the plus end with a high velocity and a supperprocessivity, which i...
Perspectives on Incorporating a Large Language Model into a Cellular and Molecular Bioengineering Graduate Course [0.03%]
关于将大型语言模型融入细胞与分子生物工程研究生课程的视角
David A Rubenstein,Carsi Kim
David A Rubenstein
Glioblastoma Cells Use an Integrin- and CD44-Mediated Motor-Clutch Mode of Migration in Brain Tissue [0.03%]
胶质母细胞瘤细胞在脑组织中使用整合素和CD44介导的运动装置迁移模式
Sarah M Anderson,Marcus Kelly,David J Odde
Sarah M Anderson
Purpose: Glioblastoma (GBM) is an aggressive malignant brain tumor with 2 year survival rates of 6.7% (Stupp et al. in J Clin Oncol Off J Am Soc Clin Oncol 25:4127-4136, 2007; Mohammed et al. in Rep Pract Oncol Radiother ...
Pathological Features of Colorectal Adenocarcinoma Patients Related to MLH1 [0.03%]
与MLH1相关的结直肠腺癌患者病理特征分析
Alexandru Adrian Bratei,Raluca-Ioana Stefan-van Staden
Alexandru Adrian Bratei
Background: MLH1, one of the MMR proteins, is linked to DNA replication, its role being to repair the incorrect DNA sequences and to replace them with proper ones. The loss of the MLH1 gene expression is part of Lynch syn...
Influence of Hematocrit Level and Integrin αIIbβIII Function on vWF-Mediated Platelet Adhesion and Shear-Induced Platelet Aggregation in a Sudden Expansion [0.03%]
红细胞压积水平和整联蛋白αIIbβIII功能对血小板黏附及剪切诱导的血小板聚集的影响研究
Connor T Watson,Shane C Ward,Stefano A Rizzo et al.
Connor T Watson et al.
Purpose: Shear-mediated thrombosis is a clinically relevant phenomenon that underlies excessive arterial thrombosis and device-induced thrombosis. Red blood cells are known to mechanically contribute to physiological hemo...
Three-Dimensional Fractal Analysis of the Interstitial Cells of Cajal Networks of Gastrointestinal Tissue Specimens [0.03%]
胃肠组织间质细胞的三维分形分析
Sue Ann Mah,Recep Avci,Jean-Marie Vanderwinden et al.
Sue Ann Mah et al.
Introduction: Several functional gastrointestinal disorders (FGIDs) have been associated with the degradation or remodeling of the network of interstitial cells of Cajal (ICC). Introducing fractal analysis to the field of...
Incorporation of ChatGPT and Other Large Language Models into a Graduate Level Computational Bioengineering Course [0.03%]
将ChatGPT和其他大型语言模型融入研究生生物工程计算课程中
Michael R King,Adam M Abdulrahman,Mark I Petrovic et al.
Michael R King et al.
The remarkable capabilities of generative artificial intelligence and large language models (LLMs) such as ChatGPT have delighted users around the world. Educators have regarded these tools as either a cause for great concern, an opportunit...
Relatively Rare Populations of Invasive Cells Drive Progression of Heterogeneous Tumors [0.03%]
侵袭性细胞的相对罕见的人群推动了异质肿瘤的发展
Susan E Leggett,Molly C Brennan,Sophia Martinez et al.
Susan E Leggett et al.
Introduction: Breast tumors often display an astonishing degree of spatial and temporal heterogeneity, which are associated with cancer progression, drug resistance, and relapse. Triple-negative breast cancer (TNBC) is a ...