THP-1 Macrophages Limit Neutrophil Transendothelial Migration in a Model Infection [0.03%]
THP-1单核细胞限制中性粒细胞在感染模型中的跨内皮迁移
Aitana Ignes-Romeu,Hannah K Weppner,Tanisha Kaur et al.
Aitana Ignes-Romeu et al.
Introduction: Dysregulated neutrophil function plays a significant role in the pathology of infections, cancer, cardiovascular diseases, and autoimmune disorders. Neutrophil activity is influenced by various cell populati...
Hypoxic Preconditioned ADSC Exosomes Enhance Vaginal Wound Healing via Accelerated Keratinocyte Proliferation and Migration Through AKT/HIF‑1α Axis Activation [0.03%]
缺氧预处理的ADSC外泌体通过激活AKT / HIF-1α轴促进阴道伤口愈合
Xiaoyun Yang,Shasha Zhang,Kewei Chen et al.
Xiaoyun Yang et al.
Purpose: Accelerating wound healing is a main consideration in surgery. The three stages of wound healing are inflammatory response, tissue repair and cell proliferation. Much research has focused on epidermal cell prolif...
Ziqing Su,Guozhang Tang,Rui Huang et al.
Ziqing Su et al.
Objectives: This review explores the potential applications of large language models (LLMs) such as ChatGPT, GPT-3.5, and GPT-4 in the medical field, aiming to encourage their prudent use, provide professional support, an...
Exosomes and Macrophages: Bidirectional Mutual Regulation in the Treatment of Diabetic Complications [0.03%]
外泌体与巨噬细胞：在糖尿病并发症治疗中的双向互调作用
Xue Li,Lianrong Yang,Shujun Xu et al.
Xue Li et al.
Purpose: The bidirectional regulation of macrophages and exosomes provides a meaningful research direction for the treatment of complications arising from both type 1 and type 2 diabetes mellitus. However, there is curren...
Pioglitazone Antagonized the Effects of Advanced Glycation End Products on Achilles Tendon Healing and Improved the Recovery of Tendon Biomechanical Properties [0.03%]
吡格列酮拮抗晚期糖基化终产物对跟腱愈合的影响并改善肌腱生物力学性能的恢复
Gengxin Jia,Xiaoyang Jia,Juan Yang et al.
Gengxin Jia et al.
Purpose: Advanced glycation end products (AGEs) often accumulate in the Achilles tendon during the course of diabetes. This study aims to determine the impact of AGEs on tendon repair and explore the role of pioglitazone ...
Dynamic Transcriptional Programs During Single NK Cell Killing: Connecting Form to Function in Cellular Immunotherapy [0.03%]
单个自然杀伤细胞杀伤过程中的动态转录计划：在细胞免疫治疗中连接形式与功能
Joseph T Decker,Matthew S Hall,Devak Nanua et al.
Joseph T Decker et al.
Introduction: Natural killer (NK) cell-based therapies are a promising new method for treating indolent cancer, however engineering new therapies is complex and progress towards therapy for solid tumors is slow. New metho...
A Label-Free Colorimetric AuNP-Aptasensor for the Rapid Detection of Vibrio cholerae O139 [0.03%]
一种检测霍乱弧菌O139的无标记比色型金纳米粒子适配子传感器方法
Masilamani Karthikeyan,Pasupathi Rathinasabapathi
Masilamani Karthikeyan
Purpose: Waterborne pathogens pose a significant threat to public health, emphasizing the continuous necessity for advancing robust detection techniques, particularly in preventing outbreaks associated with these pathogen...
Intracellular Macromolecular Crowding within Individual Stress Fibers Analyzed by Fluorescence Correlation Spectroscopy [0.03%]
利用荧光相关光谱分析单个张力纤维内的胞内大分子拥挤现象
Aria Buenaventura,Takumi Saito,Taiga Kanao et al.
Aria Buenaventura et al.
Introduction: The diffusion of cell components such as proteins is crucial to the function of all living cells. The abundance of macromolecules in cells is likely to cause a state of macromolecular crowding, but its effec...
Primary Human Cell-Derived Extracellular Matrix from Decellularized Fibroblast Microtissues with Tissue-Dependent Composition and Microstructure [0.03%]
取自去细胞化成纤维细胞微组织的原代人细胞来源的细胞外基质具有组织依赖性的组成和微观结构
Vera C Fonseca,Vivian Van,Blanche C Ip
Vera C Fonseca
Purpose: Human extracellular matrix (ECM) exhibits complex protein composition and architecture depending on tissue and disease state, which remains challenging to reverse engineer. One promising approach is based on cell...
Cellular Traction Force Holds the Potential as a Drug Testing Readout for In Vitro Cancer Metastasis [0.03%]
细胞牵引力有望成为体外癌症转移的药物检测指标
Hui Yan Liew,Xiao Hui Liew,Wei Xuan Lin et al.
Hui Yan Liew et al.
Introduction: Metastasis is responsible for 90% of cancer-related deaths worldwide. However, the potential inhibitory effects of metastasis by various anticancer drugs have been left largely unexplored. Existing preclinic...