Systemic Analysis of Tumor Cell-Induced Endothelial Calcium Signaling and Junction Disassembly [0.03%]
系统分析肿瘤细胞诱导的内皮钙信号转导及连接分解
Hsin-Hsin Peng,Cheng Dong
Hsin-Hsin Peng
It has been shown in our previous study that melanoma cells induce junction disassembly in the manner related to phospholipase C-calcium activation. In light of this observation, we have developed a mathematical model of the signaling pathw...
Measuring Receptor-Ligand Binding Kinetics on Cell Surfaces: From Adhesion Frequency to Thermal Fluctuation Methods [0.03%]
基于细胞表面受体-配体结合动力学的测量：从粘附频率到热波动方法
Wei Chen,Veronika I Zarnitsyna,Krishna K Sarangapani et al.
Wei Chen et al.
Interactions between surface-anchored receptors and ligands mediate cell-cell and cell-environment communications in many biological processes. Molecular interactions across two apposing cell membrane are governed by two-dimensional (2D) ki...
Characterization of Calcium-Mediated Intracellular and Intercellular Signaling in the rMC-1 Glial Cell Line [0.03%]
钙介导的rMC-1胶质细胞系胞内和胞间信号传导机制的研究
Diana Yu,Marius Buibas,Siu-Kei Chow et al.
Diana Yu et al.
Retinal Müller glial cells, in addition to providing homeostatic support to retinal neurons, have been shown to engage in modulation of neuronal activity and regulate vasomotor responses in the retina, among other functions. Calcium-mediat...
Calcium Concentration Effects on the Mechanical and Biochemical Properties of Chondrocyte-Alginate Constructs [0.03%]
钙离子浓度对明胶水凝胶中细胞外基质分泌的影响及机理研究
Leo Q Wan,Jie Jiang,Diana E Arnold et al.
Leo Q Wan et al.
Alginate gel crosslinked by calcium ions (Ca(2+)) has been widely used in cartilage tissue engineering. However, most studies have been largely performed in vitro in medium with a calcium concentration ([Ca(2+)]) of 1.8mM, while the calcium...
Effects of the Tumor-Leukocyte Microenvironment on Melanoma-Neutrophil Adhesion to the Endothelium in a Shear Flow [0.03%]
肿瘤-白细胞微环境对黑色素瘤-中性粒细胞在剪切应力作用下的黏附影响研究
Shile Liang,Meghan Hoskins,Payal Khanna et al.
Shile Liang et al.
The primary cause of cancer mortality is not attributed to primary tumor formation, but rather to the growth of metastases at distant organ sites. Tumor cell adhesion to blood vessel endothelium (EC) and subsequent transendothelial migratio...
Modulation of elasticity in functionally distinct domains of the tropomyosin coiled-coil [0.03%]
肌动蛋白螺旋肽功能各异区域的弹性调节
Sirish Kaushik Lakkaraju,Wonmuk Hwang
Sirish Kaushik Lakkaraju
Alpha-helical coiled-coils are common protein structural motifs. Whereas vast information is available regarding their structure, folding, and stability, far less is known about their elastic properties, even though they play mechanical rol...
Sung Sik Hur,Yihua Zhao,Yi-Shuan Li et al.
Sung Sik Hur et al.
The traction forces exerted by an adherent cell on a substrate have been studied only in the two-dimensions (2D) tangential to substrate surface (Txy). We developed a novel technique to measure the three-dimensional (3D) traction forces exe...
Effect of Electromechanical Stimulation on the Maturation of Myotubes on Aligned Electrospun Fibers [0.03%]
电刺激和机械刺激对排列纳米纤维上肌管分化的影响研究
I-Chien Liao,Jason B Liu,Nenad Bursac et al.
I-Chien Liao et al.
Tissue engineering may provide an alternative to cell injection as a therapeutic solution for myocardial infarction. A tissue-engineered muscle patch may offer better host integration and higher functional performance. This study examined t...