Modification of Cellular Cholesterol Content Affects Traction Force, Adhesion and Cell Spreading [0.03%]
细胞胆固醇含量的变化影响牵引力、粘附和细胞展开
Leann L Norman,Ratna J Oetama,Micah Dembo et al.
Leann L Norman et al.
Cellular cholesterol is a critical component of the plasma membrane, and plays a key role in determining the physical properties of the lipid bilayer, such as elasticity, viscosity, and permeability. Surprisingly, it has been shown that cho...
CytoSolve: A Scalable Computational Method for Dynamic Integration of Multiple Molecular Pathway Models [0.03%]
一种可拓展的计算方法将多种分子通路模型动态整合在一起
V A Shiva Ayyadurai,C Forbes Dewey
V A Shiva Ayyadurai
A grand challenge of computational systems biology is to create a molecular pathway model of the whole cell. Current approaches involve merging smaller molecular pathway models' source codes to create a large monolithic model (computer prog...
Rule-Based Simulation of Multi-Cellular Biological Systems-A Review of Modeling Techniques [0.03%]
基于规则的多细胞生物系统模拟综述性研究
Minki Hwang,Marc Garbey,Scott A Berceli et al.
Minki Hwang et al.
Emergent behaviors of multi-cellular biological systems (MCBS) result from the behaviors of each individual cells and their interactions with other cells and with the environment. Modeling MCBS requires incorporating these complex interacti...
Effects of Morphology vs. Cell-Cell Interactions on Endothelial Cell Stiffness [0.03%]
形态和细胞间相互作用对内皮细胞刚度的影响
Kimberly M Stroka,Helim Aranda-Espinoza
Kimberly M Stroka
Biological processes such as atherogenesis, wound healing, cancer cell metastasis, and immune cell transmigration rely on a delicate balance between Cell-Cell and cell-substrate adhesion. Cell mechanics have been shown to depend on substrat...
Shamik Sen,Sanjay Kumar
Shamik Sen
Measurement of the mechanical properties of single cells is of increasing interest both from a fundamental cell biological perspective and in the context of disease diagnostics. In this study, we show that tracking cell shape dynamics durin...
Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and Biosynthesis [0.03%]
椎间盘局部损伤导致结构、细胞和生物合成水平的变化
James C Iatridis,A J Michalek,D Purmessur et al.
James C Iatridis et al.
A literature review and new data are presented to evaluate the influence of intervertebral disc (IVD) injury on biomechanics, cellularity, inflammation, and biosynthesis. Literature and new experimental evidence support the hypothesis that ...
Micropatterning of Aptamer Beacons to Create Cytokine-Sensing Surfaces [0.03%]
用于创建细胞因子感应表面的 aptamer 凯特琳微图案化技术
Nazgul Tuleuova,Alexander Revzin
Nazgul Tuleuova
Aptamer beacons are DNA or RNA probes that bind proteins or small molecules of interest and emit signal directly upon interaction with the target analyte. This paper describes micropatterning of aptamer beacons for detection of IFN-γ-an im...
Karen Lipkow,David J Odde
Karen Lipkow
Intracellular protein concentration gradients are generally thought to be unsustainable at steady-state due to diffusion. Here we show how protein concentration gradients can theoretically be sustained indefinitely through a relatively simp...
Characterization of the Concentration-Dependence of Solute Diffusivity and Partitioning in a Model Dextran-Agarose Transport System [0.03%]
表征模型葡聚糖-琼脂糖传输系统中溶质扩散系数和分配作用的浓度依赖性
Michael B Albro,Vikram Rajan,Roland Li et al.
Michael B Albro et al.
This study reports experimental measurements of solute diffusivity and partition coefficient for various solute concentrations and gel porosities, and proposes novel constitutive relations to describe these observed values. The longer-term ...
Studying Molecular Interactions at the Single Bond Level with a Laminar Flow Chamber [0.03%]
利用层流流动室在单键水平上研究分子间的相互作用
Anne Pierres,Anne-Marie Benoliel,Pierre Bongrand
Anne Pierres
During the last decade, many investigators developed new methodologies allowing to study ligand-receptor interactions with unprecedented accuracy, up to the single bond level. Reported results include information on bond mechanical properti...