Proteolytic Activity Attenuates the Response of Endothelial Cells to Fluid Shear Stress [0.03%]
蛋白水解活性减弱内皮细胞对流体切应力反应的功能作用
Angelina E Altshuler,Mary J Morgan,Shu Chien et al.
Angelina E Altshuler et al.
Recent evidence indicates that several experimental pathophysiological conditions are associated with elevated protease activity in plasma, which impacts endothelial function. We hypothesize that extracellular structures bound to the endoth...
Nicholas S Wren,Zhixia Zhong,Russell S Schwartz et al.
Nicholas S Wren et al.
Correlations between altered nuclear shape and disease are empirically observed, but the causes of nuclear dysmorphisms are poorly understood. The nucleoskeleton, which provides the majority of the mechanical stability of the nucleus, is co...
In Vivo Multiphoton Microscopy for Investigating Biomechanical Properties of Human Skin [0.03%]
用于检测人体皮肤生物力学性质的在体多光子显微技术
Xing Liang,Benedikt W Graf,Stephen A Boppart
Xing Liang
The biomechanical properties of living cells depend on their molecular building blocks, and are important for maintaining structure and function in cells, the extracellular matrix, and tissues. These biomechanical properties and forces also...
Approximation for Cooperative Interactions of a Spatially-Detailed Cardiac Sarcomere Model [0.03%]
空间详细的心肌细肌丝模型的合作交互作用的近似
Takumi Washio,Jun-Ichi Okada,Seiryo Sugiura et al.
Takumi Washio et al.
We developed a novel ordinary differential equation (ODE) model, which produced results that correlated well with the Monte Carlo (MC) simulation when applied to a spatially-detailed model of the cardiac sarcomere. Configuration of the nove...
Daniela E Fuentes,Chilman Bae,Peter J Butler
Daniela E Fuentes
Cells dynamically interact with their physical micro-environment through the assembly of nascent focal contacts and focal adhesions. The dynamics and mechanics of these contact points are controlled by transmembrane integrins and an array o...
Synergistic Regulation of Angiogenic Sprouting by Biochemical Factors and Wall Shear Stress [0.03%]
化学因子和血管壁剪切应力对血管生成的协同调节作用
Roland Kaunas,Hojin Kang,Kayla J Bayless
Roland Kaunas
The process of sprouting angiogenesis involves activating endothelial cells in a quiescent monolayer of an existing vessel to degrade and migrate into the underlying matrix to form new blood vessels. While the roles of biochemical factors i...
Endothelial Cell Membrane Sensitivity to Shear Stress is Lipid Domain Dependent [0.03%]
内皮细胞膜剪切应力敏感性依赖于脂质域
Tristan Tabouillot,Hari S Muddana,Peter J Butler
Tristan Tabouillot
Blood flow-associated shear stress causes physiological and pathophysiological biochemical processes in endothelial cells that may be initiated by alterations in plasma membrane lipid domains characterized as liquid-ordered (l(o)), such as ...
An Oscillatory Contractile Pole-Force Component Dominates the Traction Forces Exerted by Migrating Amoeboid Cells [0.03%]
迁移的变形虫样细胞施加的牵引力主要受振荡收缩极力分量的支配
Baldomero Alonso-Latorre,Juan C Del Álamo,Ruedi Meili et al.
Baldomero Alonso-Latorre et al.
We used principal component analysis to dissect the mechanics of chemotaxis of amoeboid cells into a reduced set of dominant components of cellular traction forces and shape changes. The dominant traction force component in wild-type cells ...
Whole-Cell Electrical Activity Under Direct Mechanical Stimulus by AFM Cantilever Using Planar Patch Clamp Chip Approach [0.03%]
基于平面贴片钳芯片技术的AFM针尖直接刺激细胞机械力学信号诱发全细胞电生理反应研究
Kalpesh V Upadhye,Joseph E Candiello,Lance A Davidson et al.
Kalpesh V Upadhye et al.
Patch clamp is a powerful tool for studying the properties of ion-channels and cellular membrane. In recent years, planar patch clamp chips have been fabricated from various materials including glass, quartz, silicon, silicon nitride, polyd...
Assessment of Transport Mechanisms Underlying the Bicoid Morphogen Gradient [0.03%]
评估Bicoid形态发生素梯度的运输机制
Brian T Castle,Stephen A Howard,David J Odde
Brian T Castle
Morphogen gradients dictate the spatial patterning of multicellular organisms and are established via transport mechanisms. One of the best-characterized morphogens, Bicoid, acts as a polarity determinant in the Drosophila embryo through sp...