Wireless Devices for Optical Brain Stimulation: A Review of Current Developments for Optogenetic Applications in Freely Moving Mice [0.03%]
用于光学脑刺激的无线设备：对自由行动小鼠中基于光遗传学应用的最新发展的评价
Patrícia Silva,Luis Jacinto
Patrícia Silva
Purpose: Optogenetics is an invaluable tool to study brain circuits, but typical systems rely on tethered approaches to deliver light to the brain that hinder natural behavior. With the increasing prevalence of complex be...
Obesity-Associated Conditions Hinder Solute Drainage Function of Engineered Human Lymphatic Vessels [0.03%]
肥胖相关状况妨碍了工程化人类淋巴管的溶质引流功能
Alex J Seibel,Cheyanne L Frosti,Abderrahman R Tlemçani et al.
Alex J Seibel et al.
Purpose: Obesity is associated with poor lymphatic solute drainage. It is unclear whether the chronic inflammation, hypoxia, and hyperlipidemia that are together associated with obesity cause impaired drainage function, a...
CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro [0.03%]
CRISPR-dCas9激活MSC中的TSG-6可调节MSC衍生的细胞外囊泡的内容物并减轻人椎间盘细胞的炎症反应
Iker Martinez-Zalbidea,Gabbie Wagner,Nea Bergendahl et al.
Iker Martinez-Zalbidea et al.
Purpose: The purpose of this study was to boost the therapeutic effect of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) by overexpressing the gene TSG-6 through CRISPR activation, and assess the biologi...
Empowering High Throughput Screening of 3D Models: Automated Dispensing of Cervical and Endometrial Cancer Cells [0.03%]
赋能3D模型的高通量筛选：宫颈和子宫内膜癌细胞的自动化分配
Samantha Seymour,Ines Cadena,Mackenzie Johnson et al.
Samantha Seymour et al.
Purpose: Cervical and endometrial cancers pose significant challenges in women's healthcare due to their high mortality rates and limited treatment options. High throughput screening (HTS) of cervical and endometrial canc...
Hyperosmotic Stress Promotes the Nuclear Translocation of TFEB in Tubular Epithelial Cells Depending on Intracellular Ca2+ Signals via TRPML Channels [0.03%]
高渗应力通过TRPML通道依赖于细胞内Ca2+信号促进管状上皮细胞中TFEB的核转位
Takashi Miyano,Atsushi Suzuki,Hisaaki Konta et al.
Takashi Miyano et al.
Purpose: We previously demonstrated that hyperosmotic stress, which acts as mechanical stress, induces autophagy of tubular epithelial cells. This study aims to elucidate the molecular mechanisms of hyperosmolarity-induce...
Paul V Taufalele,Hannah K Kirkham,Cynthia A Reinhart-King
Paul V Taufalele
Purpose: Altered tissue mechanics is a prominent feature of many pathological conditions including cancer. As such, much work has been dedicated to understanding how mechanical features of tissues contribute to pathogenes...
Deciphering Mechanochemical Influences of Emergent Actomyosin Crosstalk Using QCM-D [0.03%]
使用QCM-D解析新兴肌动球蛋白相互作用的力化学影响
Emily M Kerivan,Victoria N Amari,William B Weeks et al.
Emily M Kerivan et al.
Purpose: Cytoskeletal protein ensembles exhibit emergent mechanics where behavior in teams is not necessarily the sum of the components' single molecule properties. In addition, filaments may act as force sensors that dis...
Organoids as Sophisticated Tools for Renal Cancer Research: Extensive Applications and Promising Prospects [0.03%]
类器官在肾癌研究中的广泛应用及广阔前景
Jingqiang Huang,Xianli Wang,Shengyang Ge et al.
Jingqiang Huang et al.
Background: Kidney cancer is a significant global health problem that affects nearly 1 in 25 of cancer patients. Prevalence, morbidity and mortality data associated with kidney cancer continue to increase every year, reve...
Fibroblast-Adipocyte Lineage Cell Interactions Result in Differential Production of Extracellular Matrix Proteins [0.03%]
成纤维细胞-脂肪细胞谱系细胞相互作用导致细胞外基质蛋白的差异化生成
Edward A Sander,Mariam Y El-Hattab,Kathryn R Jacobson et al.
Edward A Sander et al.
Introduction: Scarring from traumatic injury, burns, and other complications remains a significant problem that diminishes quality of life for millions of people worldwide. A common target for the development of new thera...
Simulation of Somatic Evolution Through the Introduction of Random Mutation to the Rules of Conway's Game of Life [0.03%]
通过在康威的生命游戏中引入随机突变来模拟体细胞进化
Michael R King
Michael R King
Introduction: Conway's Game of Life (GOL), and related cellular automata (CA) models, have served as interesting simulations of complex behaviors resulting from simple rules of interactions between neighboring cells, that...