Innovative Method for Fully Automated, Enzyme-Free Tissue Dissociation and Preparation for Single-Cell Analysis [0.03%]
一种创新的全自动无酶组织解离及单细胞分析样品制备方法研究
Sarah Planchak,E Celeste Welch,Benjamin Phelps et al.
Sarah Planchak et al.
Purpose: Tissue dissociation is a critical but often overlooked step in single-cell analysis, impacting data quality, reproducibility, and biological insights. Conventional enzymatic and mechanical dissociation methods in...
Examining the Effects of Quercetin on Phenotypic Characteristics of Human Mesenchymal Stem Cells [0.03%]
槲皮素对人骨髓间充质干细胞表型特性影响的研究
Thomas Needy,David Heinrichs,Vitali Maldonado et al.
Thomas Needy et al.
Introduction: A significant obstacle to mesenchymal stem cell (MSC) potency and therapeutic utility is in vitro senescence, an irreversible cessation of replication associated with age-related complications. Senolytic dru...
WNT7A mRNA Lipid Nanoparticles Promote Muscle Hypertrophy and Reduce Fatty Infiltration [0.03%]
WNT7A信使核糖核酸脂质纳米颗粒促进肌肉增生并减少脂肪浸润
Larion Martin Santiago,Kasoorelope Oguntuyo,Britney Chin-Young et al.
Larion Martin Santiago et al.
Purpose: Myosteatosis and muscle atrophy are key pathological features of skeletal muscle degeneration in chronic injuries, degenerative myopathies, and aging. While recombinant WNT7A has shown promise in stimulating musc...
Development of a Method for Visualizing and Quantifying Thrombus Formation in Extracorporeal Membrane Oxygenators [0.03%]
体外膜氧合器中血栓形成可视化和定量方法的建立
Jenny S H Wang,Amelia A Rodolf,Caleb H Moon et al.
Jenny S H Wang et al.
Purpose: Extracorporeal membrane oxygenation (ECMO) is a life-saving critical care technology that presents significant risks of medical device-associated thrombosis. We developed a complete method for collecting membrane...
An Electromechanical Model-Based Study on the Dosage Effects of Ranolazine in Treating Failing HCM Cardiomyocyte [0.03%]
基于兰索拉唑治疗肥厚性心肌病细胞剂量效应的机电模型研究
Taiwei Liu,Mi Zhou,Fuyou Liang
Taiwei Liu
Background and objective: Hypertrophic cardiomyopathy (HCM) is associated with a significant risk of progression to heart failure (HF). Extensive experimental and clinical research has highlighted the therapeutic benefits...
Endothelial Cells Stably Infected with Recombinant Kaposi's Sarcoma-Associated Herpesvirus Display Distinct Viscoelastic and Morphological Properties [0.03%]
稳定感染卡波西肉瘤相关疱疹病毒的内皮细胞表现出不同的粘弹性及形态特征
Majahonkhe M Shabangu,Melissa J Blumenthal,Danielle T Sass et al.
Majahonkhe M Shabangu et al.
Purpose: Kaposi's sarcoma-associated herpesvirus (KSHV) is a γ-herpesvirus that has a tropism for endothelial cells and leads to the development of Kaposi's sarcoma, especially in people living with HIV. The present stud...
High-Throughput Metabolomic Profiling of Skin Lesions: Comparative Study of Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma, and Normal Skin Via e-Biopsy Sampling [0.03%]
基于e-活检采样的皮肤鳞状细胞癌、基底细胞癌和正常皮肤的高通量代谢组学分析及比较研究
Leetal Louie,Julia Wise,Ariel Berl et al.
Leetal Louie et al.
Purpose: Rising rates of cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) make standard histopathology diagnostic methods a bottleneck. Using tissue molecular information for diagnostics offers a pr...
Xingyu Guo,Zian Lu,Wenbiao Xiao et al.
Xingyu Guo et al.
Scope: The annulus fibrosus (AF), as an important component of the intervertebral disc (IVD), contributes to the structural integrity and functional normality of IVD. Degenerative disc diseases (DDD), due to AF impairment...
Acteoside-Loaded Self-Healing Hydrogel Enhances Skin Wound Healing through Modulation of Hair Follicle Stem Cells [0.03%]
加载acteoside的自愈合水凝胶通过调节毛囊干细胞促进皮肤伤口愈合
Junyu Liu,Hua Wang,Caihua Zhang
Junyu Liu
Background: Skin wound healing is a complex biological process involving cellular, molecular, and physiological events. Traditional treatments often fail to provide optimal outcomes, particularly for chronic wounds. ...
Theoretical and Experimental Studies of the Dynamic Damage of Endothelial Cellular Networks Under Ultrasound Cavitation [0.03%]
超声空化下内皮细胞网络动态损伤的理论与实验研究
Chuangjian Xia,Jiwen Hu,Kun Zhou et al.
Chuangjian Xia et al.
Introduction: The interaction between endothelial cells can regulate hemostasis, vasodilation, as well as immune and inflammatory responses. Excessive loading on the endothelial cells leads to endothelial damage and endot...