Hyaluronic Acid-Coated Melt Electrowritten Scaffolds Promote Myoblast Attachment, Alignment, and Differentiation [0.03%]
透明质酸包覆的熔融电写入支架促进肌管附着、排列和分化
Alycia N Galindo,Alyssa K Chi,Ievgenii Liashenko et al.
Alycia N Galindo et al.
Purpose: In muscle tissues, anisotropic cell alignment is essential for optimal muscle fiber development and function. Biomaterials for muscle tissue engineering must guide cellular alignment while supporting cell prolife...
Uncovering Cellular Interactome Drivers of Immune Checkpoint Inhibitor Response in Advanced Melanoma Patients [0.03%]
晚期黑色素瘤患者免疫检查点抑制剂治疗反应的细胞互作谱驱动因素解析
Shay Ladd,Anne M Talkington,Mary O&#x;Sullivan et al.
Shay Ladd et al.
Purpose: Despite the success of immune checkpoint inhibitors (ICIs) that target immunosuppressive interactions, treatment resistance remains a major clinical challenge. The tumor microenvironment is comprised of tumor, im...
Surface-Engineered Mitochondria with Targeting Potential for Endothelial Repair [0.03%]
用于内皮修复的靶向工程线粒体
Brandon Applewhite,Natalia Matiuto,Aurea Del Carmen et al.
Brandon Applewhite et al.
Purpose: Mitochondrial dysfunction contributes to endothelial injury in vascular diseases and interventions. While mitochondrial transplantation offers a promising therapeutic strategy, current approaches lack target spec...
G Protein-Coupled Estrogen Receptor Regulates Mesenchymal Stem Cell Mechanotransduction and Differentiation [0.03%]
G蛋白偶联雌激素受体调控基质干细胞的力学信号转导及分化过程
Hao Wang,Ofra Ben Menachem-Zidon,Ashish Pandey et al.
Hao Wang et al.
Introduction: G protein-coupled estrogen receptor (GPER) is a heptahelix estrogen-binding G protein-coupled receptor, and a potential therapeutic target for estrogen-related cancers and diseases. Recently, GPER has been r...
Actin Branching Regulates Cell Spreading and Force on Talin, but not Activation of YAP [0.03%]
肌动蛋白分支调节细胞展开及斑马鱼talin上的作用力但不影响YAP的活化
Claudia Villalobos,Amir Sadeghifar,Jose Maggiorani et al.
Claudia Villalobos et al.
Purpose: Cells sense the mechanical properties of their environment through physical engagement and spreading, with high stiffness driving nuclear translocation of the mechanosensitive transcription factor YAP. Restrictio...
Enhancing Pluripotency and Adipogenic Differentiation in Human Adipose Tissue-Derived Stem Cells Through miR-302/367 Cluster Overexpression [0.03%]
通过miR-302/367簇过表达增强人类脂肪组织来源干细胞的多能性和向脂肪细胞分化的能力
Hossein Faghih,Maryam Khani,Mehdi Shamsara et al.
Hossein Faghih et al.
Purpose: Human adipose tissue-derived stem cells (hADSCs) have emerged as a promising source of cells for tissue engineering and regenerative medicine. However, their differentiation potential is restricted and requires e...
Development of Cell-Derived Plasma Membrane Vesicles as a Nanoparticle Encapsulation and Delivery System [0.03%]
细胞源性细胞膜囊泡作为纳米颗粒封装和输送系统的发展研究
Mahsa Kheradmandi,Amir M Farnoud,Monica M Burdick
Mahsa Kheradmandi
Purpose: Developing non-invasive delivery platforms with a high level of structural and/or functional similarity to biological membranes is highly desirable to reduce toxicity and improve targeting capacity of nanoparticl...
Alperen Yılmaz,Resul Özbilgiç,Elifsu Polatlı et al.
Alperen Yılmaz et al.
Purpose: In this study, we aimed to develop a dynamic on-chip platform to study macrophage polarization in a more physiologically relevant way by incorporating mechanical forces which have been recently shown to play impo...
Electric Field-Based Tissue Dissociation: A Paradigm Shift Toward Scalable, Enzyme-Free Single-Cell Preparation [0.03%]
基于电场的组织解离：向规模化、无酶单细胞制备的范式转变
Brijesh Sathian,Javed Iqbal,Syed Muhammad Ali
Brijesh Sathian
Engineered Extracellular Vesicles for Targeted Paclitaxel Delivery in Cancer Therapy: Advances, Challenges, and Prospects [0.03%]
癌症治疗中工程化细胞外囊泡介导的紫杉醇靶向递送：进展、挑战及前景
Mohamed J Saadh,Hanan Hassan Ahmed,Radhwan Abdul Kareem et al.
Mohamed J Saadh et al.
Scope: Extracellular vesicles (EVs) have emerged as promising cell-free delivery vehicles for cancer therapy due to their inherent biocompatibility, low immunogenicity, and natural targeting capabilities. EVs derived from...