Amyloid-β Pathology-Specific Cytokine Secretion Suppresses Neuronal Mitochondrial Metabolism [0.03%]
淀粉样蛋白病理特征性细胞因子分泌抑制神经元线粒体代谢
Madison K Kuhn,Rebecca M Fleeman,Lynne M Beidler et al.
Madison K Kuhn et al.
Introduction: Neuroinflammation and metabolic dysfunction are early alterations in Alzheimer's disease (AD) brain that are thought to contribute to disease onset and progression. Glial activation due to protein deposition...
Engineering of Trophoblast Extracellular Vesicle-Delivering Hydrogels for Localized Tolerance Induction in Cell Transplantation [0.03%]
工程化胎盘滋养层细胞外囊泡递送水凝胶实现细胞移植局部耐受诱导
Shivani C Hiremath,Jessica D Weaver
Shivani C Hiremath
Purpose: The need for chronic systemic immunosuppression, which presents a host of acute risks to transplantation patients, remains the primary limitation for the translation of many cell therapies, such as insulin secret...
Amelioration of Subglottic Stenosis by Antimicrobial Peptide Eluting Endotracheal Tubes [0.03%]
载有抗菌肽的气管插管改善亚 glottis狭窄的效果研究
Matthew R Aronson,Amrita Mehta,Ryan M Friedman et al.
Matthew R Aronson et al.
Introduction: Pediatric subglottic stenosis (SGS) results from prolonged intubation where scar tissue leads to airway narrowing that requires invasive surgery. We have recently discovered that modulating the laryngotrache...
A 3D Human Lymphatic Vessel-on-Chip Reveals the Roles of Interstitial Flow and VEGF-A/C for Lymphatic Sprouting and Discontinuous Junction Formation [0.03%]
一种三维人体淋巴管芯片，揭示了间质流和VEGF-A/C在淋巴发芽和不连续连接形成中的作用
Isabelle S Ilan,Aria R Yslas,Yansong Peng et al.
Isabelle S Ilan et al.
Introduction: Lymphatic vessels (LVs) maintain fluid homeostasis by draining excess interstitial fluid, which is accomplished by two distinct LVs: initial LVs and collecting LVs. The interstitial fluid is first drained in...
Altered Caveolin-1 Dynamics Result in Divergent Mineralization Responses in Bone and Vascular Calcification [0.03%]
caveolin-1动态改变导致骨骼和血管钙化中的不同矿化反应
Amirala Bakhshian Nik,Katherine Kaiser,Patrick Sun et al.
Amirala Bakhshian Nik et al.
Introduction: Though vascular smooth muscle cells adopt an osteogenic phenotype during pathological vascular calcification, clinical studies note an inverse correlation between bone mineral density and arterial mineral-al...
Elucidating Mechanotransduction Processes During Magnetomechanical Neuromodulation Mediated by Magnetic Nanodiscs [0.03%]
磁性纳米盘介导的磁机械神经调节过程中的力学信号转导机制研究
Amanda Gomez,Nicolas Muzzio,Ania Dudek et al.
Amanda Gomez et al.
Purpose: Noninvasive cell-type-specific manipulation of neural signaling is critical in basic neuroscience research and in developing therapies for neurological disorders. Magnetic nanotechnologies have emerged as non-inv...
Outsourcing Your Faculty Application to ChatGPT: Would this Work? Should this Work? [0.03%]
把教职申请外包给ChatGPT：这可行吗？应该这样做吗？
Michael R King
Michael R King
Bio-adhesive Macroporous Hydrogels for In Situ Recruitment and Modulation of Dendritic Cells [0.03%]
原位募集和调节树突状细胞的生物粘附大孔水凝胶
Joonsu Han,Rimsha Bhatta,Hua Wang
Joonsu Han
Introduction: Biomaterials that enable in situ recruitment and modulation of immune cells have demonstrated tremendous promise for developing potent cancer immunotherapy such as therapeutic cancer vaccine. One challenge r...
Irradiated Mammary Spheroids Elucidate Mechanisms of Macrophage-Mediated Breast Cancer Recurrence [0.03%]
辐照乳腺小球体阐明巨噬细胞介导的乳腺癌复发机制
Benjamin C Hacker,Erica J Lin,Dana C Herman et al.
Benjamin C Hacker et al.
Introduction: While most patients with triple negative breast cancer receive radiation therapy to improve outcomes, a significant subset of patients continue to experience recurrence. Macrophage infiltration into radiatio...
siRNA Lipid-Polymer Nanoparticles Targeting E-Selectin and Cyclophilin A in Bone Marrow for Combination Multiple Myeloma Therapy [0.03%]
靶向骨髓E-选择素和环磷酸酶抑制基因的 siRNA脂质聚合纳米粒联合治疗多发性骨髓瘤研究
Christian G Figueroa-Espada,Pedro P G Guimarães,Rachel S Riley et al.
Christian G Figueroa-Espada et al.
Introduction: Multiple myeloma (MM) is a hematological blood cancer of the bone marrow that remains largely incurable, in part due to its physical interactions with the bone marrow microenvironment. Such interactions enha...