T-cell fitness, metabolic tumor volume, and serum LDH levels are associated with response to axicabtagene ciloleucel [0.03%]
Risa Nishiyama,Anna Hiratsuka,Tetsuro Ochi et al.
Risa Nishiyama et al.
Axicabtagene ciloleucel (axi-cel) has demonstrated efficacy and safety in relapsed/refractory large B cell lymphoma (r/r LBCL). However, evidence from Asian populations remains limited.This study evaluated patients with r/r LBCL who underwe...
Personalized multivariable clinical prognostic model for patients with acute myeloid leukemia receiving intensive chemotherapy [0.03%]
Kengo Katsuki,Takuya Miyazaki,Moka Komaki et al.
Kengo Katsuki et al.
Purpose: This study aimed to develop and validate a personalized prognostic model for patients with newly diagnosed with acute myeloid leukemia (AML) receiving intensive cytarabine- and anthracycline-based chemotherapy. ...
Targeting drug efflux and DNA repair enhances inotuzumab ozogamicin activity in IO-resistant B-ALL cell lines [0.03%]
Naoko Ida,Miyuki Okura,Saki Tanaka et al.
Naoko Ida et al.
Inotuzumab ozogamicin (IO), an anti-CD22 antibody conjugated with calicheamicin, is highly effective against relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, acquired resistance limits the long-term efficacy of IO. ...
Treosulfan-based conditioning for hematopoietic stem cell transplantation in mucopolysaccharidosis: a pilot study [0.03%]
用于黏多糖病造血干细胞移植的替洛番预处理方案：一项前瞻性研究
Takashi Koike,Shunichi Kato,Tsuyoshi Morimoto et al.
Takashi Koike et al.
Treosulfan (Treo), a prodrug of a bifunctional alkylating agent, has been used in conditioning regimens to reduce the risk of hepatic sinusoidal obstruction syndrome. We aimed to establish a Treo-based conditioning regimen for mucopolysacch...
Allogeneic hematopoietic cell transplantation for acute myeloid leukemia in Japan: changes in practice patterns and outcomes during the past 20 years [0.03%]
日本成人急性髓性白血病异基因造血细胞移植后二十年的变迁与预后
Masamitsu Yanada,Yoshimitsu Shimomura,Satoshi Yamasaki et al.
Masamitsu Yanada et al.
This study examined changes in practice patterns and outcomes of allogeneic hematopoietic cell transplantation (HCT) over the past 20 years. Data were analyzed from a Japanese nationwide registry of consecutive adult patients with acute mye...
Junichi Sugita
Junichi Sugita
Graft-versus-host disease (GVHD) remains a major complication of allogeneic hematopoietic cell transplantation. Recent biological insights have led to a reevaluation of GVHD. It is now recognized not merely as a donor-derived immune attack,...
Rapid regression of a bulky cranial lesion in high-risk multiple myeloma with isatuximab-based quadruplet induction [0.03%]
达雷妥尤单抗联合方案诱导治疗高危多发性骨髓瘤患者巨大颅内病灶的快速退缩
Shun Ito,Takahiro Namiki,Hironao Nukariya et al.
Shun Ito et al.
A 77-year-old woman with newly diagnosed immunoglobulin (Ig)G-κ multiple myeloma presented with a massive cranial paraskeletal (PS) lesion (84 × 59 × 62 mm) compressing the occipital lobe. Fluorescence in situ hybridization of bone marro...
Splenic rupture secondary to pegfilgrastim in a healthy allogeneic peripheral blood hematopoietic stem cell donor [0.03%]
一例健康外周血造血干细胞捐献者因注射培非格司亭导致脾破裂的病例报告
Ryo Takahashi,Koichi Oya,Yuki Ishizawa et al.
Ryo Takahashi et al.
Granulocyte-colony stimulating factor (G-CSF) is widely used to mobilize peripheral blood stem cells (PBSCs) for hematopoietic cell transplantation (HCT). G-CSF is generally well-tolerated but can cause life-threatening complications such a...
Philadelphia chromosome-negative but BCR::ABL1-positive acute lymphoblastic leukemia: a real-world multicenter cohort study [0.03%]
BCR-ABL1阳性但费城染色体阴性急性淋巴细胞白血病的多中心真实世界队列研究
Shota Yokoyama,Masahiro Onozawa,Hiroyuki Kimura et al.
Shota Yokoyama et al.
Chronic myelogenous leukemia that carries the BCR::ABL1 fusion gene without cytogenetically detectable Philadelphia (Ph) chromosomes is termed masked Ph. However, the prevalence and clinical relevance of masked Ph in acute lymphoblastic leu...
Zanubrutinib for MYD88-negative Waldenström's macroglobulinemia with massive splenomegaly [0.03%]
用于MYD88阴性Waldenström巨球蛋白血症伴巨大脾肿的zanubrutinib治疗
Takashi Onaka,Kazunori Imada
Takashi Onaka