Adrien Holzgreve,Sophie C Siegmund,Liam Widjaja et al.
Adrien Holzgreve et al.
Progress in the application of 177Lu- and 225Ac-targeted radionuclide therapy in pancreatic ductal adenocarcinoma [0.03%]
Lu-177和Ac-225放射性核素治疗在胰腺导管腺癌中应用进展
Tao Jiang,Zunyu Xiao
Tao Jiang
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by the limited efficacy of current therapies and an urgent need for novel treatment strategies. Targeted radionuclide therapy (TRT) enables t...
Differential performance of statistical versus machine learning methods in partial volume correction in oncologic F18-FDG PET/CT scanning [0.03%]
统计方法与机器学习在肿瘤F18-FDG PET/CT扫描部分容积效应校正中的性能差异
Hanan K Metwally,Hesham A Gawaad,Magdy M Khalil
Hanan K Metwally
Partial volume effects (PVE) in positron emission tomography (PET) imaging introduce quantification inaccuracies, particularly in small or heterogeneous lesions, necessitating precise correction methodologies. This study systematically eval...
No-carrier-added 177Lu production eliminates persistent urine radioactivity: implications for safe expansion of targeted radionuclide therapy [0.03%]
无载带剂生产177 Lu可消除尿液的持续放射性：对靶向核素治疗安全扩展的影响
Junichi Tsuchiya,Takumi Narita,Tatsuhiko Anzai et al.
Junichi Tsuchiya et al.
Objective: ¹⁷⁷Lu is an approved radionuclide for targeted radionuclide therapy (TRT), first established with ¹⁷⁷Lu-DOTATATE for neuroendocrine tumors, and subsequently with PSMA-targeted therapy. The widespread adop...
Quantitative Imaging Evaluation of Structural and Densitometric Changes in Major Salivary Glands After 177Lu PSMA Radioligand Therapy [0.03%]
177Lu-PSMA放射配体治疗后主要唾液腺结构和密度变化的定量影像评估
Nihat Köylüce,Fadime Demir
Nihat Köylüce
Objective: Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) provides a survival advantage in metastatic castration-resistant prostate cancer (mCRPC). However, the physiologically high PSMA-liga...
Integrating functional and volumetric assessments in 90Y radioembolization: added value of [⁹⁹ᵐTc]Mebrofenin scintigraphy [0.03%]
结合功能性和体积评估的90Y放射栓塞治疗：99mTc-Mebrofenin闪烁显像的附加价值
Ali Kibar,Sertac Asa,Mohammad Abuqbeitah et al.
Ali Kibar et al.
Objectives: In this study, we aimed to evaluate the association between liver clearance values obtained from pre-treatment [⁹⁹ᵐTc]mebrofenin hepatobiliary scintigraphy and conventional liver function scores and biochem...
Phase I/IIa clinical trial of 68Ga-PSMA-11 synthesized by a newly developed automated module using cyclotron-generated 68Ga [0.03%]
新型模块自动化合成的68Ga-PSMA-11的一期/二期临床试验(使用回旋加速器生产的68Ga)
Shigeyasu Sugawara,Shozo Okamoto,Noriko Kanno et al.
Shigeyasu Sugawara et al.
Objective: This Phase I/IIa study evaluated the safety, pharmacokinetics, internal radiation dosimetry, and image quality of cyclotron-produced ⁶⁸Ga-PSMA-11 synthesized using an automated module in a Japanese population...
Clinical significance of suspicious incidental FDG uptake: a comparison between digital PET/CT and conventional PET/CT [0.03%]
可疑意外FDG摄取的临床意义：数字PET/CT与常规PET/CT的比较
Takuya Kitamura,Naoto Kawaguchi,Marika Matsuoka et al.
Takuya Kitamura et al.
Objective: To compare the clinical significance of incidental 18F-fluorodeoxyglucose (18F-FDG) uptake detected on silicon photomultiplier-based digital positron emission tomography/computed tomography (dPET) versus conven...
Development and validation of a machine learning-based hierarchical classification model for predicting the early therapeutic response to initial 131I therapy in papillary thyroid carcinoma [0.03%]
开发和验证基于机器学习的分层分类模型以预测乳头状甲状腺癌初始131I治疗早期疗效
Zhiyue Tang,Zhengjie Wang,Hua Pang
Zhiyue Tang
Objective: Personalized tools for accurately predicting papillary thyroid carcinoma (PTC) patients' response to initial 131I therapy are lacking. This study aimed to develop a machine learning (ML) model for prediction of...
Impact of posture change on patient-specific absorbed dose estimation in nuclear medicine [0.03%]
体位变化对核医学中患者特异性吸收剂量估算的影响
Mei Takahashi,Phornpailin Pairodsantikul,Hiroshi Watabe et al.
Mei Takahashi et al.
Purpose: Internal dosimetry in nuclear medicine commonly assumes a fixed upright standing posture of subjects. The use of four recent therapeutic radionuclides with longer half-lives causes long exposure to patients durin...