The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: two triggers for one disease? [0.03%]
酒精性和非酒精性脂肪肝炎的免疫病理发病机制：两种诱因引发的一种疾病？
Luca Valenti,Anna Ludovica Fracanzani,Silvia Fargion
Luca Valenti
Alcoholic liver disease and nonalcoholic liver disease represent a leading cause of liver disease and share similar pathogenic mechanisms among which activation of the immune system plays a key role. The main events consist in (a) activatio...
Paolo Calabrò,Enrica Golia,Edward T H Yeh
Paolo Calabrò
A large body of literature supports the idea that inflammation plays a pivotal role in all phases of atherosclerosis, from the fatty streak lesion formation to the acute coronary event due to vulnerable plaque rupture. Indeed, vascular infl...
Update on statin-mediated anti-inflammatory activities in atherosclerosis [0.03%]
他汀类药物介导的动脉粥样硬化炎症反应最新研究进展
Fabrizio Montecucco,François Mach
Fabrizio Montecucco
Anti-inflammatory activities of statins in atherosclerosis have been well documented by both basic research and clinical studies. Statins have been introduced in the 1980s as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors to blo...
Connexins participate in the initiation and progression of atherosclerosis [0.03%]
连接子蛋白参与动脉粥样硬化的发生和发展
Sandrine Morel,Laurent Burnier,Brenda R Kwak
Sandrine Morel
Connexins are members of a large family of transmembrane proteins that form hemichannels or gap junctions. These channels allow the exchange of ions and small metabolites between the cytosol and extracellular space or between neighboring ce...
Obstructive sleep apnea, immuno-inflammation, and atherosclerosis [0.03%]
阻塞性睡眠呼吸暂停、免疫炎症与动脉粥样硬化之间的关系
Claire Arnaud,Maurice Dematteis,Jean-Louis Pepin et al.
Claire Arnaud et al.
Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder leading to cardiovascular and metabolic complications. OSA is also a multicomponent disorder, with intermittent hypoxia (IH) as the main trigger for the associated cardiovas...
Fabrizio Montecucco,François Mach
Fabrizio Montecucco
The emerging role of the endocannabinoid system in cardiovascular disease [0.03%]
内源大麻素系统在心血管疾病中作用的初步研究
Pál Pacher,Sabine Steffens
Pál Pacher
Endocannabinoids are endogenous bioactive lipid mediators present both in the brain and various peripheral tissues, which exert their biological effects via interaction with specific G-protein-coupled cannabinoid receptors, the CB(1) and CB...
Advanced glycation end products and C-peptide-modulators in diabetic vasculopathy and atherogenesis [0.03%]
糖尿病血管病变和动脉粥样硬化中的晚期糖基化终末产物及C肽调节剂
Daniel Walcher,Nikolaus Marx
Daniel Walcher
Patients with insulin resistance and early type 2 diabetes exhibit an increased propensity to develop a diffuse and extensive pattern of arteriosclerosis. Diabetic subjects show a remarkable increase in vascular complications, including myo...
Hafid Ait-Oufella,Soraya Taleb,Ziad Mallat et al.
Hafid Ait-Oufella et al.
Atherosclerosis is a chronic inflammatory disease of the arterial wall where both innate and adaptive immune responses contribute to disease initiation and progression. Recent studies established that subtypes of T cells, regulatory T cells...
Oliver Soehnlein,Christian Weber
Oliver Soehnlein
Chronic inflammation is the underlying pathophysiological mechanism of atherosclerosis. Prominent suspects being involved in atherosclerosis are lymphocytes, platelets, and endothelial cells. However, recent advances suggest a potent role f...