Epithelial-immune interface in asthma: Mechanistic insights driving novel therapeutic strategies [0.03%]
哮喘上皮-免疫界面：驱动新型治疗策略的机制见解
Jingyi Deng,Jun Zhao,Wenlu Zhu et al.
Jingyi Deng et al.
Asthma is a heterogeneous chronic respiratory syndrome driven by complex interactions between environmental triggers and the host immune system while biologic therapies targeting downstream type 2 cytokines (e.g., anti-IL-5, anti-IL-4Rα) h...
PD-1⁺ CD8⁺ T cells: roles of PD-1 beyond an exhaustion marker [0.03%]
PD-1⁺ CD8⁺ T细胞：PD-1作用超出耗竭标志物的范畴
Jingyi Chen,Zixiang Chen,Liangjie Xu et al.
Jingyi Chen et al.
Programmed cell death protein 1 (PD-1) has long been considered a central molecule in CD8⁺ T cell exhaustion and immunosuppression. However, recent studies have revealed that PD-1⁺CD8⁺ T cells are not a homogeneous population of terminal...
The interaction between inflammation and estrogen in adenomyosis : from molecular mechanisms to therapeutic strategies [0.03%]
炎性疾病与子宫腺肌症雌激素相互作用：从分子机制到治疗策略
Feng Li,Huai Jian Wang,Yu Zhang et al.
Feng Li et al.
Adenomyosis is a common and difficult disease in gynecology. Its main clinical manifestations include uterine hypertrophy, excessive menstruation, pelvic pain and infertility, which have a serious impact on women's health. Seriously affects...
The complex of gut microbial metabolites and sex hormones in Alzheimer's disease [0.03%]
阿尔茨海默病中肠道微生物代谢物和性激素的复杂关系
Aisa Bahar,Meisam Khazaei,Hamed Tahmasebi
Aisa Bahar
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder with a complex pathophysiological mechanism and a marked sex difference in prevalence and disease severity, with women being more affected and showing a more aggressive di...
Endometrial pathophysiology and pregnancy: from mechanism to intervention [0.03%]
子宫内膜病理生理和妊娠问题：从机制到干预措施
Lianghui Diao,Joanne Kwak-Kim
Lianghui Diao
This special issue features contributions from international experts, providing new perspectives on endometrial physiology and pathology: from regenerative mechanisms, epigenetic memory, immune checkpoints, and endocrine metabolic regulatio...
Advances in understanding the dual roles of testicular immune responses: From immune privilege to inflammation [0.03%]
睾丸免疫反应的双重作用机制研究进展：从免疫豁免到炎症反应
Xianglong Wang,Feng Jiang,Haijuan Yang et al.
Xianglong Wang et al.
The testis is an immune-privileged organ that balances protection of developing germ cells with the need to respond to pathogens. This review summarizes the dual nature of testicular immunity. A tolerogenic microenvironment is maintained th...
Climate change-associated heat extremes and immune dysregulation: emerging links with autoimmunity, allergy, and infectious diseases [0.03%]
气候变化相关的高温极端与免疫紊乱：与自身免疫、过敏和传染病的新兴联系
Paraskevi C Fragkou,Charalampos D Moschopoulos,Dominika Marová et al.
Paraskevi C Fragkou et al.
Climate extremes are increasingly shaping both environmental and human health outcomes. Global warming has led to a rise in the frequency, duration, and intensity of extreme temperature events, with heatwaves emerging as one of the most haz...
The cancer-microbiome axis: Mechanisms and emerging therapeutic strategies [0.03%]
癌症-微生物组轴：机制和新兴的治疗策略
Maria Rae Walker,Marlene Schwarzfischer,Michael Scharl
Maria Rae Walker
Cytokine-mediated, organ-specific immune modulation and dysregulation of innate lymphocytes in sepsis [0.03%]
脓毒症中细胞因子介导的免疫调节和固有淋巴细胞的异常调节
Seoyeon Han,Sejong Bae,Seungwon Ryu
Seoyeon Han
Butyrate remodels the immune-epigenetic-gut-lung axis: Emerging mechanisms and therapeutic perspectives in asthma [0.03%]
丁酸重塑免疫-表观遗传-肠-肺轴在哮喘中的新兴机制和治疗前景
Yuqia Xie,Guochun Huang,Jun Zhao et al.
Yuqia Xie et al.