Advances in understanding the dual roles of testicular immune responses: From immune privilege to inflammation [0.03%]
睾丸免疫反应的双重作用机制研究进展：从免疫豁免到炎症反应
Xianglong Wang,Feng Jiang,Haijuan Yang et al.
Xianglong Wang et al.
The testis is an immune-privileged organ that balances protection of developing germ cells with the need to respond to pathogens. This review summarizes the dual nature of testicular immunity. A tolerogenic microenvironment is maintained th...
Climate change-associated heat extremes and immune dysregulation: emerging links with autoimmunity, allergy, and infectious diseases [0.03%]
气候变化相关的高温极端与免疫紊乱：与自身免疫、过敏和传染病的新兴联系
Paraskevi C Fragkou,Charalampos D Moschopoulos,Dominika Marová et al.
Paraskevi C Fragkou et al.
Climate extremes are increasingly shaping both environmental and human health outcomes. Global warming has led to a rise in the frequency, duration, and intensity of extreme temperature events, with heatwaves emerging as one of the most haz...
The cancer-microbiome axis: Mechanisms and emerging therapeutic strategies [0.03%]
癌症-微生物组轴：机制和新兴的治疗策略
Maria Rae Walker,Marlene Schwarzfischer,Michael Scharl
Maria Rae Walker
Cytokine-mediated, organ-specific immune modulation and dysregulation of innate lymphocytes in sepsis [0.03%]
脓毒症中细胞因子介导的免疫调节和固有淋巴细胞的异常调节
Seoyeon Han,Sejong Bae,Seungwon Ryu
Seoyeon Han
Butyrate remodels the immune-epigenetic-gut-lung axis: Emerging mechanisms and therapeutic perspectives in asthma [0.03%]
丁酸重塑免疫-表观遗传-肠-肺轴在哮喘中的新兴机制和治疗前景
Yuqia Xie,Guochun Huang,Jun Zhao et al.
Yuqia Xie et al.
Effect of the intestinal microbiota on TH17 cell-derived cytokines in the context of intestinal inflammation [0.03%]
肠道微生物对肠炎背景下TH17细胞源性细胞因子的影响
Justus Neuendorff,Samuel Huber,Penelope Pelczar
Justus Neuendorff
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory condition of the gastrointestinal tract (GI tract). Despite extensive research, its exact pathogenesis remains elusive. However, multiple factors are thought to be inv...
Paneth cells as orchestrators of epithelial barrier defense and emerging therapeutic targets in inflammatory bowel disease [0.03%]
潘氏细胞在肠上皮屏障防御中的作用及在炎症性肠病治疗中的潜力
Lena Erkert,Lea-Maxie Haag,Christoph Becker
Lena Erkert
First described by Joseph Paneth in 1888 in the small intestine, particularly in the crypts of Lieberkühn, Paneth cells have since emerged as a critical subtype of intestinal epithelial cells (IECs), which together constitute the body’s l...
Emerging microbiome-directed therapies in inflammatory bowel disease: beyond diet modification and FMT [0.03%]
炎症性肠病中的新兴微生物组导向治疗：饮食调节和FMT之外的疗法
Andrea Carolina Quiroga-Centeno,Konstantina Atanasova,Matthias Philip Ebert et al.
Andrea Carolina Quiroga-Centeno et al.
Inflammatory bowel disease (IBD) is a multifactorial and heterogeneous disorder that remains challenging to manage. Growing evidence implicates the gut microbiome as a key player in IBD pathogenesis, with many patients displaying intestinal...
The microbiome's hidden influence: preclinical insights into inflammatory responses in necrotizing enterocolitis [0.03%]
微生物组的隐性影响：坏死性小肠结肠炎炎症反应的临床前见解
Briana M Peterson,Ina Rudloff,Nadia S Deen et al.
Briana M Peterson et al.
Necrotizing enterocolitis (NEC) is the most common surgical emergency in preterm infants; nonetheless, besides supportive measures, no treatment is available. NEC significantly increases length of hospitalization of preterm infants, causes ...
Systemic sclerosis: pathogenic mechanisms and their implications for treatment [0.03%]
系统性硬化病：致病机制及其对治疗的意义
Alain Lescoat,Valérie Lecureur,Johann E Gudjonsson et al.
Alain Lescoat et al.
Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by a triad of pathogenic mechanisms, including: a) microvascular hyperreactivity secondary to endothelial dysfunction, b) dysregulated immune activation of both in...