Emerging microbiome-directed therapies in inflammatory bowel disease: beyond diet modification and FMT [0.03%]
炎症性肠病中的新兴微生物组导向治疗：饮食调节和FMT之外的疗法
Andrea Carolina Quiroga-Centeno,Konstantina Atanasova,Matthias Philip Ebert et al.
Andrea Carolina Quiroga-Centeno et al.
Inflammatory bowel disease (IBD) is a multifactorial and heterogeneous disorder that remains challenging to manage. Growing evidence implicates the gut microbiome as a key player in IBD pathogenesis, with many patients displaying intestinal...
The microbiome's hidden influence: preclinical insights into inflammatory responses in necrotizing enterocolitis [0.03%]
微生物组的隐性影响：坏死性小肠结肠炎炎症反应的临床前见解
Briana M Peterson,Ina Rudloff,Nadia S Deen et al.
Briana M Peterson et al.
Necrotizing enterocolitis (NEC) is the most common surgical emergency in preterm infants; nonetheless, besides supportive measures, no treatment is available. NEC significantly increases length of hospitalization of preterm infants, causes ...
Systemic sclerosis: pathogenic mechanisms and their implications for treatment [0.03%]
系统性硬化病：致病机制及其对治疗的意义
Alain Lescoat,Valérie Lecureur,Johann E Gudjonsson et al.
Alain Lescoat et al.
Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by a triad of pathogenic mechanisms, including: a) microvascular hyperreactivity secondary to endothelial dysfunction, b) dysregulated immune activation of both in...
Correction: Therapeutic mechanisms of exclusive enteral nutrition in crohn's disease [0.03%]
克罗恩病排他性肠内营养治疗机制的纠正意见
Tina Krammel,Jiatong Nie,Deborah Häcker et al.
Tina Krammel et al.
Published Erratum
Seminars in immunopathology. 2025 Nov 11;47(1):40. DOI:10.1007/s00281-025-01067-4 2025
Pyoderma gangrenosum: pathogenetic mechanisms and their implications for treatment [0.03%]
脓疱性文身样皮病：发病机制及其治疗意义
Chiara Moltrasio,Maurizio Romagnuolo,Gianluca Tavoletti et al.
Chiara Moltrasio et al.
Pyoderma gangrenosum (PG) is a rare inflammatory skin disease belonging to the group of neutrophilic dermatoses. The pathogenesis of PG involves a predisposing genetic background that facilitates a dysregulated innate and adaptive immune re...
Crosstalk between the microbiota and intestinal dendritic cells in IBD [0.03%]
肠道微生态系统与树突细胞在炎症性肠病中的相互作用
Philine Letz,Samuel Huber,Lis N Velasquez
Philine Letz
Conventional dendritic cells (cDCs) play a pivotal role in orchestrating the delicate balance between immunity and tolerance within the gastrointestinal tract by interacting with other cell types, particularly T cells. Meanwhile, the microb...
Regenerating the uterus: translational advances in endometrial bioengineering and immunotherapeutics [0.03%]
子宫再生：子宫内膜组织工程与免疫治疗的转化研究进展
Danbi Lee,Youn-Jung Kang,Haengseok Song
Danbi Lee
Uterine disorders, such as thin endometrium and intrauterine adhesions, remain significant challenges in reproductive medicine, often leading to infertility and poor pregnancy outcomes. Recent advances in regenerative medicine and tissue en...
Maternal and placental galectins: key players in the feto-maternal symbiotic tango [0.03%]
母体和胎盘半乳糖凝集素：胎盘屏障共生探戈中的关键因子
Orsolya Oravecz,Yiran Xie,Andrea Balogh et al.
Orsolya Oravecz et al.
Galectins, a family of β-galactoside-binding proteins, are critical in regulating feto-maternal interactions during pregnancy. Their evolutionary trajectory is reflected in their expression patterns and diverse functions in embryo implanta...
Margitta Worm,Kristijan Pazur,Payam Morakabati et al.
Margitta Worm et al.
Anaphylaxis is a severe, potentially life-threatening allergic reaction that can occur through both IgE- and non-IgE-mediated pathways. The classic IgE-mediated pathway involves allergen-specific IgE binding to FcεRI on mast cells and baso...
Christopher Urbschat,Petra C Arck
Christopher Urbschat