David Espie,Emmanuel Donnadieu
David Espie
Adoptive transfer of T-cells expressing chimeric antigen receptors (CAR) has shown remarkable clinical efficacy against advanced B-cell malignancies. Nonetheless, the field of CAR T-cells is currently facing several major challenges. In par...
Multiparameter single-cell proteomic technologies give new insights into the biology of ovarian tumors [0.03%]
多参数单细胞蛋白组学技术为卵巢肿瘤的生物学提供了新的见解
Ionut-Gabriel Funingana,Jacob S Bedia,Ying-Wen Huang et al.
Ionut-Gabriel Funingana et al.
High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy. Its diagnosis at advanced stage compounded with its excessive genomic and cellular heterogeneity make curative treatment challenging. Two critical therape...
Single-cell technologies uncover intra-tumor heterogeneity in childhood cancers [0.03%]
单细胞技术揭示儿童癌症中的肿瘤内异质性
Yu-Chen Lo,Yuxuan Liu,Marte Kammersgaard et al.
Yu-Chen Lo et al.
Childhood cancer is the second leading cause of death in children aged 1 to 14. Although survival rates have vastly improved over the past 40 years, cancer resistance and relapse remain a significant challenge. Advances in single-cell techn...
Giulia Franciosa,Anders H Kverneland,Agnete W P Jensen et al.
Giulia Franciosa et al.
Cancer survival and progression depend on the ability of tumor cells to avoid immune recognition. Advances in the understanding of cancer immunity and tumor immune escape mechanisms enabled the development of immunotherapeutic approaches. I...
Single-cell high-dimensional imaging mass cytometry: one step beyond in oncology [0.03%]
单细胞高维成像质谱流式细胞术：在肿瘤学中的一个进步步骤
Yaël Glasson,Laure-Agnès Chépeaux,Anne-Sophie Dumé et al.
Yaël Glasson et al.
Solid tumors have a dynamic ecosystem in which malignant and non-malignant (endothelial, stromal, and immune) cell types constantly interact. Importantly, the abundance, localization, and functional orientation of each cell component within...
Stephanie Medina,Rebecca A Ihrie,Jonathan M Irish
Stephanie Medina
Suspension and imaging cytometry techniques that simultaneously measure hundreds of cellular features are powering a new era of cell biology and transforming our understanding of human tissues and tumors. However, a central challenge remain...
Ana Maia,Anna Schöllhorn,Juliane Schuhmacher et al.
Ana Maia et al.
Tumour cells do not exist as isolated entities. Instead, they are surrounded by a variety of cells and extracellular matrix, which form the tumour microenvironment (TME). The interaction between cancer cells and their microenvironment is in...
Miao Wang,Angus W Thomson,Fang Yu et al.
Miao Wang et al.
Unrestrained excessive inflammatory responses exacerbate ischemic brain injury and impede post-stroke brain recovery. CD4+CD25+Foxp3+ regulatory T (Treg) cells play important immunosuppressive roles to curtail inflammatory responses and reg...
The immunopathology of B lymphocytes during stroke-induced injury and repair [0.03%]
中风诱发的损伤和修复过程中B淋巴细胞的免疫病理反应
Mary K Malone,Thomas A Ujas,Daimen R S Britsch et al.
Mary K Malone et al.
B cells, also known as B lymphocytes or lymphoid lineage cells, are a historically understudied cell population with regard to brain-related injuries and diseases. However, an increasing number of publications have begun to elucidate the di...
Immune biology of NSCLC revealed by single-cell technologies: implications for the development of biomarkers in patients treated with immunotherapy [0.03%]
单细胞技术揭示的NSCLC免疫生物学：对于免疫治疗患者生物标志物开发的影响
J Wlosik,S Fattori,P Rochigneux et al.
J Wlosik et al.
First-line immunotherapy in non-small-cell lung cancer largely improved patients' survival. PD-L1 testing is required before immune checkpoint inhibitor initiation. However, this biomarker fails to accurately predict patients' response. On ...