Immune compartments at the brain's borders in health and neurovascular diseases [0.03%]
健康状态和神经血管疾病下的大脑边界免疫区隔
Jennifer E Goertz,Lidia Garcia-Bonilla,Costantino Iadecola et al.
Jennifer E Goertz et al.
Recent evidence implicates cranial border immune compartments in the meninges, choroid plexus, circumventricular organs, and skull bone marrow in several neuroinflammatory and neoplastic diseases. Their pathogenic importance has also been d...
Novel immunotherapeutic combinations moving forward: the modulation of the immunosuppressive microenvironment [0.03%]
新型免疫治疗组合的前景：改变免疫抑制微环境
Mads Hald Andersen
Mads Hald Andersen
Role of glia and extracellular matrix in controlling neuroplasticity in the central nervous system [0.03%]
胶质细胞和胞外基质在中枢神经系统神经可塑性中的作用
Egor Dzyubenko,Dirk M Hermann
Egor Dzyubenko
Neuronal plasticity is critical for the maintenance and modulation of brain activity. Emerging evidence indicates that glial cells actively shape neuroplasticity, allowing for highly flexible regulation of synaptic transmission, neuronal ex...
Differences in the post-stroke innate immune response between young and old [0.03%]
年轻和老年个体免疫反应的差异性研究
Mattia Gallizioli,Maria Arbaizar-Rovirosa,David Brea et al.
Mattia Gallizioli et al.
Aging is associated to progressive changes impairing fundamental cellular and tissue functions, and the relationships amongst them through the vascular and immune systems. Aging factors are key to understanding the pathophysiology of stroke...
The role of macrophages in the tumor microenvironment and tumor metabolism [0.03%]
肿瘤微环境和肿瘤代谢中的巨噬细胞的作用
Pritam Sadhukhan,Tanguy Y Seiwert
Pritam Sadhukhan
The complexity and plasticity of the tumor microenvironment (TME) make it difficult to fully understand the intratumoral regulation of different cell types and their activities. Macrophages play a crucial role in the signaling dynamics of t...
Ines Sophie Schädlich,Riekje Winzer,Joschi Stabernack et al.
Ines Sophie Schädlich et al.
In ischemic stroke, the primary neuronal injury caused by the disruption of energy supply is further exacerbated by secondary sterile inflammation. The inflammatory cascade is largely initiated by the purine adenosine triphosphate (ATP) whi...
Harnessing the n+1 dimensions of single-cell omics data for the prediction and prevention of human diseases [0.03%]
利用单细胞组学数据的n+1维特性预测和预防人类疾病
Dyani Gaudilliere,Brice Gaudilliere
Dyani Gaudilliere
Jakob Einhaus,Xiaoyuan Han,Dorien Feyaerts et al.
Jakob Einhaus et al.
Oral mucosal pathologies comprise an array of diseases with worldwide prevalence and medical relevance. Affecting a confined space with crucial physiological and social functions, oral pathologies can be mutilating and drastically reduce qu...
Neuroimaging is the new "spatial omic": multi-omic approaches to neuro-inflammation and immuno-thrombosis in acute ischemic stroke [0.03%]
神经影像学是新的“空间组学”：急性缺血性脑卒中神经炎症和免疫血栓形成的多组学方法
Benjamin Maïer,Amy S Tsai,Jakob F Einhaus et al.
Benjamin Maïer et al.
Ischemic stroke (IS) is the leading cause of acquired disability and the second leading cause of dementia and mortality. Current treatments for IS are primarily focused on revascularization of the occluded artery. However, only 10% of patie...
Combination immunotherapy with synthetic long peptides and chemotherapy or PD-1 blocker for cancers caused by human papilloma virus type 16 [0.03%]
用于人乳头瘤病毒16型所致癌症的合成长肽联合免疫治疗与化疗或PD-1阻滞剂治療
Cornelis J M Melief,Esmé van der Gracht,Anna-Sophia Wiekmeijer
Cornelis J M Melief
Therapeutic vaccination of premalignant conditions and of different stages of cancer can be accomplished with several platforms including DNA vaccines, RNA vaccines, synthetic long peptides (SLP), and recombinant viruses. We successfully us...