Takahiro Kageyama,Takashi Ito,Shigeru Tanaka et al.
Takahiro Kageyama et al.
The lungs serve as the primary organ for respiration, facilitating the vital exchange of gases with the bloodstream. Given their perpetual exposure to external particulates and pathogens, they possess intricate protective barriers. Cellular...
Shiyu Ayukawa,Nagisa Kamoshita,Takeshi Maruyama
Shiyu Ayukawa
Epithelial cells, which are non-immune cells, not only function as a physical defence barrier but also continuously monitor and eliminate aberrant epithelial cells in their vicinity. In other words, it has become evident that epithelial cel...
Disease pathogenesis and barrier functions regulated by group 3 innate lymphoid cells [0.03%]
第三组固有淋巴样细胞调控的疾病发生和屏障功能
Ayana Mori,Hiroshi Ohno,Naoko Satoh-Takayama
Ayana Mori
The mucosal surface is in constant contact with foreign antigens and is regulated by unique mechanisms that are different from immune responses in the peripheral organs. For the last several decades, only adaptive immune cells such as helpe...
Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity [0.03%]
糖蛋白2作为肠道守门人维持黏膜的炎症与免疫平衡
Zhongwei Zhang,Izumi Tanaka,Rika Nakahashi-Ouchida et al.
Zhongwei Zhang et al.
Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) ...
Danilo Gomes Moriel,Diego Piccioli,Maria Michelina Raso et al.
Danilo Gomes Moriel et al.
The COVID-19 pandemic had a significant economic and health impact worldwide. It also reinforced the misperception that only viruses can pose a threat to human existence, overlooking that bacteria (e.g., plague and cholera) have severely ha...
Maddalena Ferranna
Maddalena Ferranna
Despite the rapid development of safe and effective COVID-19 vaccines and the widely recognized health and economic benefits of vaccination, there exist stark differences in vaccination rates across country income groups. While more than 70...
Florian Krammer
Florian Krammer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged late in 2019 and caused the coronavirus disease 2019 (COVID-19) pandemic that has so far claimed approximately 20 million lives. Vaccines were developed quickly, became av...
Unveiling the immunopathology of stroke: a comprehensive view on brain-immune interaction [0.03%]
揭开卒中免疫病理的面纱：脑-免疫交互作用的全面观点
Tim Magnus,Arthur Liesz
Tim Magnus
R D Szepanowski,S Haupeltshofer,S E Vonhof et al.
R D Szepanowski et al.
Despite years of encouraging translational research, ischemic stroke still remains as one of the highest unmet medical needs nowadays, causing a tremendous burden to health care systems worldwide. Following an ischemic insult, a complex sig...
The role of circulating cell-free DNA as an inflammatory mediator after stroke [0.03%]
循环细胞游离DNA在卒中后作为炎症介质的作用
Stefan Roth,Saskia R Wernsdorf,Arthur Liesz
Stefan Roth
Stroke is the second leading cause of death worldwide and a leading cause of disability. Clinical and experimental studies highlighted the complex role of the immune system in the pathophysiology of stroke. Ischemic brain injury leads to th...