The role of the mucosal barrier system in maintaining gut symbiosis to prevent intestinal inflammation [0.03%]
黏膜屏障系统在维持肠道共生和预防肠炎中的作用
Ryu Okumura,Kiyoshi Takeda
Ryu Okumura
In the intestinal tract, where numerous intestinal bacteria reside, intestinal epithelial cells produce and release various antimicrobial molecules that form a complex barrier on the mucosal surface. These barrier molecules can be classifie...
Role of mucosal IgA antibodies as novel therapies to enhance mucosal barriers [0.03%]
黏膜IgA抗体作为增强黏膜屏障的新疗法的作用
Peng Gao,Naoki Morita,Reiko Shinkura
Peng Gao
To prevent infection, the experience of the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) pandemic has led to recognition of the importance of not only vaccines but also the strengthening of mucosal barriers by secretor...
Glycan diversity in ovarian cancer: Unraveling the immune interplay and therapeutic prospects [0.03%]
卵巢癌中的糖链多样性：揭示免疫互作及治疗前景
Gerrit Wolters-Eisfeld,Leticia Oliveira-Ferrer
Gerrit Wolters-Eisfeld
Ovarian cancer remains a formidable challenge in oncology due to its late-stage diagnosis and limited treatment options. Recent research has revealed the intricate interplay between glycan diversity and the immune microenvironment within ov...
Role of Hyaluronic acid and its chemical derivatives in immunity during homeostasis, cancer and tissue regeneration [0.03%]
透明质酸及其化学衍生物在家稳态、癌症和组织再生过程中免疫作用的研究进展
Paolo Rosales,Daiana Vitale,Antonella Icardi et al.
Paolo Rosales et al.
Over the last few decades, scientists have recognized the critical role that various components of the extracellular matrix (ECM) play in maintaining homeostatic immunity. Besides, dysregulation in the synthesis or degradation levels of the...
The fetal programming effect of maternal immune activation (MIA) on the offspring's immune system [0.03%]
母体免疫激活对后代免疫系统的胎儿编程效应
Naomi Hofsink,Lucianne Groenink,Torsten Plösch
Naomi Hofsink
The first 1000 days of life is a critical period of development in which adverse circumstances can have long-term consequences for the child's health. Maternal immune activation is associated with increased risk of neurodevelopmental disord...
The mark of success: The role of vaccine-induced skin scar formation for BCG and smallpox vaccine-associated clinical benefits [0.03%]
成功与否的标志：卡介苗和天花疫苗相关临床获益的皮肤瘢痕形成作用
Ole Bæk,Frederik Schaltz-Buchholzer,Anita Campbell et al.
Ole Bæk et al.
Skin scar formation following Bacille Calmette-Guérin (BCG) or smallpox (Vaccinia) vaccination is an established marker of successful vaccination and 'vaccine take'. Potent pathogen-specific (tuberculosis; smallpox) and pathogen-agnostic (...
Apoorva Ramamurthy,Anna Tommasi,Krishanu Saha
Apoorva Ramamurthy
Biomedical research has witnessed significant strides in manufacturing chimeric antigen receptor T cell (CAR-T) therapies, marking a transformative era in cellular immunotherapy. Nevertheless, existing manufacturing methods for autologous c...
Maria Victoria Bazzano,Angela Köninger,Maria Emilia Solano
Maria Victoria Bazzano
Throughout the individual's reproductive period of life the ovary undergoes continues changes, including cyclic processes of cell death, tissue regeneration, proliferation, and vascularization. Tissue-resident leucocytes particularly macrop...
Crosstalk between the DNA damage response and cellular senescence drives aging and age-related diseases [0.03%]
DNA损伤反应与细胞衰老之间的串扰驱动衰老及相关疾病
Ajmal Ahmad,Anneliesse Braden,Sazzad Khan et al.
Ajmal Ahmad et al.
Cellular senescence is a crucial process of irreversible cell-cycle arrest, in which cells remain alive, but permanently unable to proliferate in response to distinct types of stressors. Accumulating evidence suggests that DNA damage builds...
Catherine Ptaschinski,Bernhard F Gibbs
Catherine Ptaschinski
Allergic diseases affect up to 40% of the global population with a substantial rise in food allergies, in particular, over the past decades. For the majority of individuals with allergy fundamental programming of a pro-allergic immune syste...