Dermatomyositis: focus on cutaneous features, etiopathogenetic mechanisms and their implications for treatment [0.03%]
皮肌炎的皮肤表现、病因发病机制及其对治疗的意义
Hammad Ali,Aretha On,Enze Xing et al.
Hammad Ali et al.
Dermatomyositis (DM) is an infrequently encountered idiopathic inflammatory myopathy distinguished by distinctive cutaneous manifestations and/or progressive muscle weakness. This review provides an updated exploration of DM, emphasizing cu...
Macrophage clock of pregnancy: circadian and metabolic control of decidual macrophage [0.03%]
妊娠巨噬细胞钟：蜕膜巨噬细胞的昼夜节律和代谢调控
Dongyong Yang,Kristin Thiele,Tailang Yin et al.
Dongyong Yang et al.
The temporal regulation of immune responses during pregnancy is crucial for successful gestation. Yet, the specific mechanisms controlling macrophage function across gestational stages remain poorly understood. Here, we introduce the concep...
Immunopathological insights into endometriosis: from research advances to future treatments [0.03%]
免疫病理视角下的子宫内膜异位症研究进展及未来治疗方向
Yangyang Dai,Zi Ye,Xiang Lin et al.
Yangyang Dai et al.
Endometriosis is a chronic gynecological disease and a major global concern for women's health. With advancing knowledge of the condition, the classic definition of endometriosis as "endometrium-like tissue outside the uterus" now appears i...
Impact of endocrine disrupting chemicals on macrophages at the maternal-fetal interface [0.03%]
内分泌干扰物对母胎界面巨噬细胞的影响
Bin Zhao,Qinsheng Lu,Miaojuan Chen et al.
Bin Zhao et al.
Pregnancy is a complex and dynamic process, immune homeostasis at the maternal-fetal interface is one of the keys to a successful pregnancy and essential for fetal nutrient exchange and the establishment of immune tolerance. Healthy pregnan...
Krammel Tina,Nie Jiatong,Häcker Deborah et al.
Krammel Tina et al.
Crohn's disease (CD) is a chronic, relapsing multifactorial inflammatory condition of the gastrointestinal tract, which is diagnosed under the age of 17 in 25% of patients, categorized as pediatric CD (pCD). Exclusive enteral nutrition (EEN...
Birte Ohm,Anastasios D Giannou,David Harriman et al.
Birte Ohm et al.
In solid organ transplantation, chimerism inevitably occurs via the coexistence of donor-derived cells from the graft and host cells throughout the recipient. However, long-term immunosuppressive treatment is needed to suppress host immune ...
Xiaohui Hu,Siying Lai,Aihua Liao
Xiaohui Hu
A successful pregnancy relies on the precise regulation of the maternal immune system to recognize and tolerate the allogeneic fetus, while simultaneously preventing infection. Immune checkpoint molecules (ICMs), such as programmed death re...
Mothers and mosquitoes: climate change contributes to the spread of vector-borne pathogens posing a substantial threat to pregnant women [0.03%]
气候变暖导致媒介传播病原体扩散，孕妇面临巨大威胁
Pauline Wiemers,Isabel Graf,Marylyn M Addo et al.
Pauline Wiemers et al.
Infectious diseases have threatened individuals and societies since the dawn of humanity. Certain population groups, including pregnant women, young children and the elderly, are particularly vulnerable to severe infections. Over the past f...
The sweet and the bitter sides of galectin-1 in immunity: its role in immune cell functions, apoptosis, and immunotherapies for cancer with a focus on T cells [0.03%]
免疫中的岩藻糖结合蛋白-1的双刃剑作用：其在免疫细胞功能、细胞凋亡及癌症免疫疗法（尤其是T细胞）中的角色
Julianna Novák,Tamás Takács,Álmos Tilajka et al.
Julianna Novák et al.
Galectin-1 (Gal-1), a member of the β-galactoside-binding soluble lectin family, is a double-edged sword in immunity. On one hand, it plays a crucial role in regulating diverse immune cell functions, including the apoptosis of activated T ...
Microbiota-dependent modulation of intestinal anti-inflammatory CD4+ T cell responses [0.03%]
肠道依赖微生物群调节抗炎性CD4+T细胞反应
Madeline Edwards,Leonie Brockmann
Madeline Edwards
Barrier organs such as the gastrointestinal tract, lungs, and skin are colonized by diverse microbial strains, including bacteria, viruses, and fungi. These microorganisms, collectively known as the commensal microbiota, play critical roles...