Kalani Ratnasiri,Aaron J Wilk,Madeline J Lee et al.
Kalani Ratnasiri et al.
The twenty-first century has seen the emergence of many epidemic and pandemic viruses, with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate intracellular parasites, viruses rely on host cells to replicate and prod...
Highly multiplexed spatial profiling with CODEX: bioinformatic analysis and application in human disease [0.03%]
CODEX高通量空间分析：生物信息学分析及其在人类疾病中的应用
Wilson Kuswanto,Garry Nolan,Guolan Lu
Wilson Kuswanto
Multiplexed imaging, which enables spatial localization of proteins and RNA to cells within tissues, complements existing multi-omic technologies and has deepened our understanding of health and disease. CODEX, a multiplexed single-cell ima...
Samuele Notarbartolo,Sergio Abrignani
Samuele Notarbartolo
CD4+ and CD8+ T lymphocytes mediate most of the adaptive immune response against tumors. Naïve T lymphocytes specific for tumor antigens are primed in lymph nodes by dendritic cells. Upon activation, antigen-specific T cells proliferate an...
Muhammad Bilal Tariq,Juneyoung Lee,Louise D McCullough
Muhammad Bilal Tariq
Ischemic stroke is a leading cause of morbidity and mortality and disproportionally affects women, in part due to their higher longevity. Older women have poorer outcomes after stroke with high rates of cognitive deficits, depression, and r...
Systemic innate myeloid responses to acute ischaemic and haemorrhagic stroke [0.03%]
急性缺血性和出血性卒中的系统固有髓系反应
Ruth Stephens,John R Grainger,Craig J Smith et al.
Ruth Stephens et al.
Acute ischaemic and haemorrhagic stroke account for significant disability and morbidity burdens worldwide. The myeloid arm of the peripheral innate immune system is critical in the immunological response to acute ischaemic and haemorrhagic...
Heterogeneity of tissue-resident immunity across organs and in health and disease [0.03%]
组织驻留性免疫在不同器官和健康与疾病情况下的异质性
Petra Clara Arck,Federica Sallusto
Petra Clara Arck
Tissue-resident immunity in the lung: a first-line defense at the environmental interface [0.03%]
组织驻留免疫：环境界面上的一线防御机制
Dimitra E Zazara,Ioannis Belios,Jöran Lücke et al.
Dimitra E Zazara et al.
The lung is a vital organ that incessantly faces external environmental challenges. Its homeostasis and unimpeded vital function are ensured by the respiratory epithelium working hand in hand with an intricate fine-tuned tissue-resident imm...
Mads Hald Andersen
Mads Hald Andersen
The identification and characterization of tumor antigens are central objectives in developing anti-cancer immunotherapy. Traditionally, tumor-associated antigens (TAAs) are considered relatively restricted to tumor cells (i.e., overexpress...
David A Hafler,Lauren H Sansing
David A Hafler
Beyond direct killing-novel cellular immunotherapeutic strategies to reshape the tumor microenvironment [0.03%]
超越直接杀伤力——重塑肿瘤微环境的新型细胞免疫治疗策略
Duc Huynh,Pia Winter,Florian Märkl et al.
Duc Huynh et al.
The clinical use of cellular immunotherapies is gaining momentum and the number of approved indications is steadily increasing. One class of cellular therapies-chimeric antigen receptor (CAR)-modified T cells-has achieved impressive results...