Proteome Profiles of Hypercholesterolemic Patients with and Without FH Treated with a PCSK9 Inhibitor: A Comparison of Depleted and Nondepleted Samples in a Pilot Study [0.03%]
一项试点研究：通过比较未经富集和富集的样本，评估FH患者和非FH高胆固醇血症患者使用PCSK9抑制剂治疗前后的蛋白组特征
Dana Dlouha,Petr Pompach,Jana Horackova et al.
Dana Dlouha et al.
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors offer a novel approach for reducing low-density lipoprotein cholesterol (LDL-C) levels in patients with familial hypercholesterolemia (FH). In o...
Comparative Study
Proteomics. Clinical applications. 2026 May;20(3):e70043. DOI:10.1002/prca.70043 2026
Proteomic Analysis of Cervicovaginal Fluid for Diagnostic Endometriosis Biomarker Discovery [0.03%]
蛋白质组分析宫颈阴道液诊断子宫内膜异位症生物标志物发现
Emily S J Paterson,Simon Scheck,Torsten Kleffmann et al.
Emily S J Paterson et al.
Purpose: Endometriosis is a prevalent inflammatory condition characterised by the presence of endometrial-like tissue outside the uterus and is associated with significant challenges, including diagnostic delays and conti...
Proteomic Analysis of Cerebrospinal Fluid from Severe COVID-19 Patients Reveals Prognostic Biomarkers Associated with Disease Outcome [0.03%]
重症新冠患者的脑脊液蛋白质组分析发现了与疾病预后相关的生物标志物
Harry Alexopoulos,Martina Samiotaki,Eirini Gkogkou et al.
Harry Alexopoulos et al.
Purpose: Coronavirus disease 2019 (COVID-19) has highlighted significant neurological complications in severe cases. Cerebrospinal fluid (CSF) proteomics could reveal biomarkers related to clinical outcome among criticall...
A Network-Based Association of IBD and Colorectal Cancer Using Proteomics Data [0.03%]
基于蛋白质组数据的IBD与结直肠癌关联的网络分析
Jaiya Dhami,Swarnima Kollampallath Radhakrishnan,Dominic Russ et al.
Jaiya Dhami et al.
Background: Colorectal cancer (CRC) is a major cause of morbidity and mortality, with chronic inflammation from inflammatory bowel disease (IBD) representing a well-established risk factor. Clarifying shared molecular mec...
Integrated Proteomic and Transcriptomic Analysis of Adipose Tissue-Derived Small Extracellular Vesicles in Ischemic Stroke [0.03%]
整合蛋白质组学和转录组学分析缺血性卒中脂肪组织来源的小细胞外囊泡
Zhichen Liao,Chen Sang,Wen Dong et al.
Zhichen Liao et al.
Purpose: Ischemic stroke (IS) is a severe neurological disease with limited treatment options. Subcutaneous adipose tissue-derived small extracellular vesicles (SAT-sEVs), which are readily accessible and abundant, have e...
Simple, Fast, and Reliable Analysis of Label-Free Proteomics Data With the Proteomics Eye (ProtE) [0.03%]
简单、快速和可靠的无标记蛋白质组学数据分析方法——基于ProtE蛋白质组学分析软件
Theodoros Margelos,Manousos Makridakis,Charis Gonidaki et al.
Theodoros Margelos et al.
In label-free mass spectrometry experiments, the data output is typically a proteome table that requires further processing, quality testing, and visualization to fully interpret the captured proteomic signals. Currently, post-quantificatio...
Non-Targeted Analysis of Extracellular Vesicle-Enriched Plasma Proteome Between Early and Late Rugby Playing Career [0.03%]
职业生涯早期和晚期进行橄榄球运动的血浆外泌体富集蛋白组的非靶向分析
Abhishek Jagan,Yusuke Nishimura,Tim Donnovan et al.
Abhishek Jagan et al.
Purpose: Rugby players experience high-impact collisions, potentially increasing their risk of neurodegenerative conditions. This study investigates whether the plasma proteome of extracellular vesicles (EV) provides biom...
Roberto Rasslan,Marcia Kiyomi Koike,Marcel Cerqueira Cesar Machado et al.
Roberto Rasslan et al.
Severe acute pancreatitis (SAP) involves dynamic shifts from inflammation to immunosuppression, where peptidomic profile evolution may reveal prognostic biomarkers. Here, the plasma peptidome of rats with taurocholate-induced SAP at 1, 3, 6...
Increased Serum Levels of LDHA and TPI1 in Patients With Polycystic Ovary Syndrome [0.03%]
多囊卵巢综合征患者中LDHA和TPI1的血清水平升高
Wenjing Wang,Tizhen Yan,Manna Sun et al.
Wenjing Wang et al.
Background: Polycystic ovary syndrome (PCOS) is a metabolic disorder affecting women of reproductive age, and its etiology remains unclear. Therefore, it is crucial to identify biomarkers of the metabolic disturbances in ...
A Standard Operating Procedure for Protein Extraction From Abdominal Aortic Aneurysm Tissue: Enhancing Proteomics Applications [0.03%]
腹主动脉瘤组织蛋白提取的标准操作程序：增强蛋白质组学应用
Telmo Baltazar,Fábio Trindade,Rita Nogueira-Ferreira et al.
Telmo Baltazar et al.
Purpose: The identification of putative biomarkers for AAA can be achieved through shotgun proteomics. However, tissue heterogeneity hampers its reproducible homogenization and protein extraction. Thus, we aimed to optimi...