A Network-Based Association of IBD and Colorectal Cancer Using Proteomics Data [0.03%]
基于蛋白质组数据的IBD与结直肠癌关联的网络分析
Jaiya Dhami,Swarnima Kollampallath Radhakrishnan,Dominic Russ et al.
Jaiya Dhami et al.
Background: Colorectal cancer (CRC) is a major cause of morbidity and mortality, with chronic inflammation from inflammatory bowel disease (IBD) representing a well-established risk factor. Clarifying shared molecular mec...
Integrated Proteomic and Transcriptomic Analysis of Adipose Tissue-Derived Small Extracellular Vesicles in Ischemic Stroke [0.03%]
整合蛋白质组学和转录组学分析缺血性卒中脂肪组织来源的小细胞外囊泡
Zhichen Liao,Chen Sang,Wen Dong et al.
Zhichen Liao et al.
Purpose: Ischemic stroke (IS) is a severe neurological disease with limited treatment options. Subcutaneous adipose tissue-derived small extracellular vesicles (SAT-sEVs), which are readily accessible and abundant, have e...
Simple, Fast, and Reliable Analysis of Label-Free Proteomics Data With the Proteomics Eye (ProtE) [0.03%]
简单、快速和可靠的无标记蛋白质组学数据分析方法——基于ProtE蛋白质组学分析软件
Theodoros Margelos,Manousos Makridakis,Charis Gonidaki et al.
Theodoros Margelos et al.
In label-free mass spectrometry experiments, the data output is typically a proteome table that requires further processing, quality testing, and visualization to fully interpret the captured proteomic signals. Currently, post-quantificatio...
Non-Targeted Analysis of Extracellular Vesicle-Enriched Plasma Proteome Between Early and Late Rugby Playing Career [0.03%]
职业生涯早期和晚期进行橄榄球运动的血浆外泌体富集蛋白组的非靶向分析
Abhishek Jagan,Yusuke Nishimura,Tim Donnovan et al.
Abhishek Jagan et al.
Purpose: Rugby players experience high-impact collisions, potentially increasing their risk of neurodegenerative conditions. This study investigates whether the plasma proteome of extracellular vesicles (EV) provides biom...
Roberto Rasslan,Marcia Kiyomi Koike,Marcel Cerqueira Cesar Machado et al.
Roberto Rasslan et al.
Severe acute pancreatitis (SAP) involves dynamic shifts from inflammation to immunosuppression, where peptidomic profile evolution may reveal prognostic biomarkers. Here, the plasma peptidome of rats with taurocholate-induced SAP at 1, 3, 6...
Increased Serum Levels of LDHA and TPI1 in Patients With Polycystic Ovary Syndrome [0.03%]
多囊卵巢综合征患者中LDHA和TPI1的血清水平升高
Wenjing Wang,Tizhen Yan,Manna Sun et al.
Wenjing Wang et al.
Background: Polycystic ovary syndrome (PCOS) is a metabolic disorder affecting women of reproductive age, and its etiology remains unclear. Therefore, it is crucial to identify biomarkers of the metabolic disturbances in ...
A Standard Operating Procedure for Protein Extraction From Abdominal Aortic Aneurysm Tissue: Enhancing Proteomics Applications [0.03%]
腹主动脉瘤组织蛋白提取的标准操作程序：增强蛋白质组学应用
Telmo Baltazar,Fábio Trindade,Rita Nogueira-Ferreira et al.
Telmo Baltazar et al.
Purpose: The identification of putative biomarkers for AAA can be achieved through shotgun proteomics. However, tissue heterogeneity hampers its reproducible homogenization and protein extraction. Thus, we aimed to optimi...
Zhi-Yi Zhang,Tao Ding,Jie Kong et al.
Zhi-Yi Zhang et al.
Purpose: Ubiquitylation is a vital post-translational modification involved in various biological processes, yet its role in the human hypothalamus remains largely unexplored. This study aims to profile the ubiquitinome o...
Nguyen Quoc Khanh Le
Nguyen Quoc Khanh Le
Proteomic Insights Into the Pathogenesis of Intracerebral Hemorrhage: The Role of Blend Sign in Hematoma Expansion [0.03%]
蛋白组学视角下的脑出血发病机制研究及血肿扩大与“混合征”的关系研究
Hang Hang,Shanpeng Liu,Likun Wang et al.
Hang Hang et al.
Objective: The "blend sign" is a critical CT imaging marker for predicting hematoma expansion in intracerebral hemorrhage (ICH). This study aimed to elucidate its underlying pathological mechanisms by comparing proteomic ...