Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes [0.03%]
端周分裂：细胞周期中的一种新的细胞命运，导致巨核细胞和肝细胞多倍体形成
Qi-Hua Hua,Xuechun Zhang,Ruifeng Tian et al.
Qi-Hua Hua et al.
Megakaryocytes and hepatocytes are unique cells in mammals that undergo polyploidization through endomitosis in terminal differentiation. Many polyploidization regulators and underlying mechanisms have been reported, most of which are tight...
Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect-related diseases [0.03%]
基于纳米技术的溶酶体/自噬缺陷修复及其在相关疾病治疗中的应用展望
Xiaodan Huang,Yue Fang,Jie Song et al.
Xiaodan Huang et al.
The dysfunction of the lysosome and autophagy-lysosome system serves as a driving force for neurodegenerative diseases, metabolic disorders, inflammatory conditions, and other related diseases, closely influencing their onset and progressio...
Improvement of neutral protease activity of Bacillus amyloliquefaciens LX-6 by combined ribosome engineering and medium optimization and its application in soybean meal fermentation [0.03%]
枯草芽孢杆菌LX-6中性蛋白酶的翻译水平增强及其在豆粕发酵中的应用
Yifan Zhu,Xinyi Huang,Tao Han et al.
Yifan Zhu et al.
Soybean meal (SBM) prepared by soybean crushing is the most popular protein source in the poultry and livestock industries (Cai et al., 2015) due to its economic manufacture, high protein content, and good nutritional value. Despite these b...
Potential effect of endothelial progenitor cells on pentylenetetrazole-induced seizures in rats: an evaluation of relevant lncRNAs [0.03%]
血管内皮祖细胞对戊四唑诱导的癫痫发作大鼠相关长链非编码RNA表达的影响及其作用效应研究
Shimaa O Ali,Nancy N Shahin,Marwa M Safar et al.
Shimaa O Ali et al.
Objectives: The use of stem cells is a promising strategy for seizure treatment owing to their unique characteristics. We investigated the role of endothelial progenitor cells (EPCs) in a pentylenetetrazole (PTZ)-induce...
Mitochondria derived from human embryonic stem cell-derived mesenchymal stem cells alleviate the inflammatory response in human gingival fibroblasts [0.03%]
人胚胎干细胞源间充质干细胞的线粒体可缓解炎症反应
Bicong Gao,Chenlu Shen,Kejia Lv et al.
Bicong Gao et al.
Periodontitis is a common oral disease caused by bacteria coupled with an excessive host immune response. Stem cell therapy can be a promising treatment strategy for periodontitis, but the relevant mechanism is complicated. This study aimed...
Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health [0.03%]
柑橘属水果通过抗氧化和调节脂质代谢改善女性生殖健康的作用机制及其潜力
Yiyan Yang,Jue Zhou
Yiyan Yang
Citrus, which has been consumed internationally for a long time, is widely used as a health food. Citrus and its active components exert significant effects on oxidative stress and lipid metabolism, which are closely associated with female ...
Liya Wei,Zizhan Li,Niannian Zhong et al.
Liya Wei et al.
Lymph node metastasis (LNM) is a crucial risk factor influencing an unfavorable prognosis in specific cancers. Fundamental research illuminates our understanding of tumor behavior and identifies valuable therapeutic targets. Nevertheless, t...
Exploiting targeted degradation of cyclins and cyclin-dependent kinases for cancer therapeutics: a review [0.03%]
靶向cyclin和cyclin依赖型激酶降解用于癌症治疗：综述
Suya Zheng,Ye Chen,Zhipeng Zhu et al.
Suya Zheng et al.
Cancer is characterized by abnormal cell proliferation. Cyclins and cyclin-dependent kinases (CDKs) have been recognized as essential regulators of the intricate cell cycle, orchestrating DNA replication and transcription, RNA splicing, and...
A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis [0.03%]
一名持续性嗜酸性粒细胞增多的男性患者发生心脏骤停和自发性肾出血：强调早期诊断嗜酸细胞性肉芽肿伴血管炎的重要性
Jinya Lin,Rending Wang,Yuanyuan Zhu et al.
Jinya Lin et al.
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare multi-system disease that presents significant diagnostic challenges due to its complexity and low incidence (White and Dubey, 2023). It affects males and females equally, thoug...
Competitive roles of slow/delta oscillation-nesting-mediated sleep disruption under acute methamphetamine exposure in monkeys [0.03%]
急性麻精药品暴露诱发猴慢波睡眠减少的机制研究
Xin Lv,Jie Liu,Shuo Ma et al.
Xin Lv et al.
Abuse of amphetamine-based stimulants is a primary public health concern. Recent studies have underscored a troubling escalation in the inappropriate use of prescription amphetamine-based stimulants. However, the neurophysiological mechanis...