Pediatric inflammatory bowel disease in mother‒child pairs: clinical risk factors and gut microbiota characteristics [0.03%]
母子对中儿童炎症性肠病的临床危险因素及肠道微生态特征分析
Cunzheng Zhang,Ruqiao Duan,Nini Dai et al.
Cunzheng Zhang et al.
Objectives: The risk factors and role of mother‒child gut microbiota in pediatric inflammatory bowel disease (PIBD) remain unclear. We aimed to explore the clinical risk factors associated with PIBD, analyze the characte...
Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases [0.03%]
Keap1/Nrf2信号通路及线粒体自噬在肝脏疾病中的作用
Qihui Zhou,Panpan Cen,Zhi Chen et al.
Qihui Zhou et al.
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an intracellular transcription factor that helps protect against oxidative stress in different types of cells under pathological conditions. Mitochondria are vital organelles that functi...
Interplay between gut microbiota and intestinal lipid metabolism:mechanisms and implications [0.03%]
肠道微生物与肠脂代谢的相互作用：机制及意义
Bingqing Hang,Yuhao Wang
Bingqing Hang
The gut microbiota is an indispensable symbiotic entity within the human holobiont, serving as a critical regulator of host lipid metabolism homeostasis. Therefore, it has emerged as a central subject of research in the pathophysiology of m...
Yangqing Shao,Yitong Zhang,Wenxuan Zhu et al.
Yangqing Shao et al.
Hippo signaling is a highly conserved pathway central to diverse cellular processes. Dysregulation of this pathway not only leads to developmental abnormalities but is also closely related to the occurrence and progression of various cancer...
Circadian genes CLOCK and BMAL1 in cancer: mechanistic insights and therapeutic strategies [0.03%]
节律基因CLOCK和BMAL1在癌症中的作用：机制及治疗策略
Yuli Shen,Yuqian Zhao,Xue Sun et al.
Yuli Shen et al.
The circadian clock is a highly conserved timekeeping system in organisms, which maintains physiological homeostasis by precisely regulating periodic fluctuations in gene expression. Substantial clinical and experimental evidence has establ...
Harnessing chemical communication in plant-microbiome and intra-microbiome interactions [0.03%]
植物微生物组和微生物组内化学信号交流的利用
Hongfu Li,Yaxin Hu,Siqi Chen et al.
Hongfu Li et al.
Chemical communication in plant-microbiome and intra-microbiome interactions weaves a complex network, critically shaping ecosystem stability and agricultural productivity. This non-contact interaction is driven by small-molecule signals th...
Successful in situ 5-aminolevulinic acid photodynamic therapy in a 53-year-old female with cutaneous squamous cell carcinoma [0.03%]
5-氨基酮戊酸光动力疗法成功治疗一名53岁老年女性皮肤鳞状细胞癌病例报告
Limin Luo,Xiaoling Jiang,Jianjun Qiao et al.
Limin Luo et al.
Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), as certain forms of non-melanoma skin cancer (NMSC) or keratinocyte carcinoma, are the most common forms of malignant neoplasms worldwide (Sharp et al., 2024). BCC and...
A practice guideline for therapeutic drug monitoring of mycophenolic acid for solid organ transplants [0.03%]
实体器官移植患者鸟胺酸乙酰转移酶治疗药物监测实践指南
Shuang Liu,Hongsheng Chen,Zaiwei Song et al.
Shuang Liu et al.
Mycophenolic acid (MPA), the active moiety of both mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS), serves as a primary immunosuppressant for maintaining solid organ transplants. Therapeutic drug monitoring (TDM...
NRF2 nuclear translocation and interaction with DUSP1 regulate the osteogenic differentiation of murine mandibular osteoblasts stimulated with Porphyromonas gingivalis lipopolysaccharide [0.03%]
NRF2核转位及其与DUSP1的相互作用调节牙龈卟啉单胞菌脂多糖刺激的小鼠下颌成骨细胞分化中的成骨分化
Xufei Yu,Jiaqi Bao,Yingming Wei et al.
Xufei Yu et al.
BACKGROUND: Periodontitis is characterized by alveolar bone resorption, aggravated by osteoblast dysfunction, and associated with intracellular oxidative stress linked to the nuclear factor erythroid 2-related factor 2 (NRF2) level. We eval...
Three-dimensional (3D) printing-assisted freeze-casting of processed pyritum-doped β-tricalcium phosphate biomimetic scaffold with angiogenesis and bone regeneration capability [0.03%]
一种用于血管生成和骨再生的β-三钙磷灰石生物模拟支架的冻铸及三维(3D)打印工艺
Chenxu Wei,Zongan Li,Xiaoyun Liang et al.
Chenxu Wei et al.
Bone repair remains an important target in tissue engineering, making the development of bioactive scaffolds for effective bone defect repair a critical objective. In this study, β-tricalcium phosphate (β-TCP) scaffolds incorporated with ...