PICK1 modulates the proliferation and migration of gastric cancer cells by regulating TLR4 [0.03%]
PICK1通过调节TLR4调控胃癌细胞的增殖和迁移
Kaiqiang Li,Yimin Yang,Yaling Wang et al.
Kaiqiang Li et al.
Protein interacting with C kinase 1 (PICK1) interacts with a variety of membrane proteins and receptors involved in nervous system diseases and multiple cancers. However, the role of PICK1 in gastric cancer remains unclear. In the present w...
Real-world data and evidence: pioneering frontiers in precision oncology [0.03%]
真实世界数据和证据：精准肿瘤学的前沿探索
Jingxin Jiang,Weiwei Pan,Liyang Sun et al.
Jingxin Jiang et al.
Real-world studies (RWSs) have emerged as a transformative force in oncology research, complementing traditional randomized controlled trials (RCTs) by providing comprehensive insights into cancer care within routine clinical settings. This...
Future of PARP inhibitors in cancer treatment: overcoming resistance and enhancing efficacy with combination therapies [0.03%]
克服耐药性及利用联合疗法增强疗效使PARP抑制剂在癌症治疗中大有可为
Muhammad Shoaib,Zeeshan Ahmad Bhutta,Ahsan Javed et al.
Muhammad Shoaib et al.
Poly(ADP-ribose) polymerase (PARP) is a family of proteins that play a crucial role in diverse cellular processes, including DNA repair, cell death, and changes in chromatin structure. PARP inhibitors (PARPi) have been recognized as notable...
TRPV1: from structure to function- a multidimensional target for therapeutic advances [0.03%]
从结构到功能： TRPV1的治疗靶点潜力
Yi Liu,Fuqin Duan,Runpeng Lin et al.
Yi Liu et al.
Transient receptor potential vanilloid subtype 1 (TRPV1), a polymodally activated, calcium-permeable non-selective cation channel, is broadly present in all parts of the body, with notable expression in the nociceptive neurons. Both physiol...
Drug-assisted synthesis of copper nanoparticles and their induction of cuproptosis and necrosis for breast cancer therapy [0.03%]
药物辅助合成铜纳米颗粒及其诱导乳腺癌细胞杯状凋亡和坏死的治疗作用研究
Yuewen Wang,Jingjie Gao,Yuying Cheng et al.
Yuewen Wang et al.
Neurokinin-1 receptor (NK1R), a member of the G protein-coupled receptor (GPCR) family, contributes to multiple pathological processes, including pain, chronic inflammation, and cancer (Gutierrez et al., 2019; Robinson et al., 2023). Curren...
Changes of folate constituents and contents in pakchoi as affected by nitrate to ammonium ratio in nutrient solution under hydroponic conditions [0.03%]
不同硝铵比例营养液中叶用甜菜叶甲胺基酸和叶酸含量及组成的动态变化研究
Yongcong Zhu,Wei Cheng,Yuemin Ni et al.
Yongcong Zhu et al.
Vegetables are important dietary sources of folate for human nutrition. The influence of different nitrogen doses and forms on changes in primary nitrogen metabolism, such as amino acid and protein synthesis, in plants is well established. ...
Management of exogenous lipoid pneumonia after fuel aspiration: a single-center experience [0.03%]
吸入燃油所致外源性脂质肺炎的临床特征及治疗体会
Congying Song,Ping Wang,Yuanqiang Lu
Congying Song
Exogenous lipoid pneumonia (ELP) following hydrocarbon aspiration is an unusual but severe condition. This study aimed to summarize the cases of pneumonitis following fuel aspiration from a single center to serve as a useful reference for c...
Depleting CBR1 increases chemosensitivity by reducing stemness and quiescence traits in non-small cell lung cancer [0.03%]
CBR1基因沉默通过降低肿瘤干细胞特性增敏非小细胞肺癌耐药肿瘤干细胞放射治疗抵抗性
Weiwen Li,Jialu Zhao,Weihong Lan et al.
Weiwen Li et al.
Carbonyl reductase 1 (CBR1), a member of the short-chain dehydrogenase/reductase (SDR) superfamily, is implicated in tumor progression and treatment resistance. However, its role in non-small cell lung cancer (NSCLC) remains unclear. This s...
Constructing a PANoptosis-based prognostic signature to evaluate the immune landscape and therapeutic response in clear cell renal cell carcinoma [0.03%]
基于PANoptosis构建预后标志物以评估透明细胞肾细胞癌的免疫图谱和治疗反应
Yu Dong,Zitong Yang,Zhinan Xia et al.
Yu Dong et al.
Objective: To identify pyroptosis, apoptosis, and necroptosis (PANoptosis)-related genes (PRGs) in clear cell renal cell carcinoma (ccRCC) for patient stratification and prognosis prediction. ...
Single-cell RNA-sequencing-guided reactive oxygen species-scavenging hydrogel design for regeneration of osteoporotic bone [0.03%]
基于单细胞RNA测序的活性氧清除水凝胶的设计促进骨质疏松骨再生
Wei Hu,Tianyi Fei,Zhichao Liu et al.
Wei Hu et al.
The pathological microenvironment of osteoporosis poses a substantial clinical challenge for bone defect regeneration. Through single-cell RNA-sequencing (scRNA-seq) analysis, we identified a reactive oxygen species (ROS)-overloading osteob...