Zhiyuan Pan,Guofen Lin,Hao Liu et al.
Zhiyuan Pan et al.
Ribosome is an intracellular ribonucleoprotein particle that serves as the site of protein biosynthesis. Ribosomal dysfunction caused by mutations in genes encoding ribosomal proteins (RPs) and ribosome biogenesis factors (RBFs) can lead to...
Unmet needs of patients with intravascular large B-cell lymphoma: three case reports and a literature review [0.03%]
血管内大B细胞淋巴瘤患者未被满足的治疗需求：三例病例报告及文献回顾
Xian Li,Ru Luo,Jiaming Xu et al.
Xian Li et al.
Intravascular large B-cell lymphoma (IVLBCL), a rare subtype of non-Hodgkin lymphoma, is classified as an independent subtype of extranodal diffuse large B-cell lymphoma (DLBCL) in the 2008 World Health Organization (WHO) Classification (Tu...
Metagenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in elderly Chinese people [0.03%]
元基因组学揭示老人肠道菌群中大肠杆菌比例增加
Jinyou Li,Yue Wu,Yichen Yang et al.
Jinyou Li et al.
Gut microbial communities are likely remodeled in tandem with accumulated physiological decline during aging, yet there is limited understanding of gut microbiome variation in advanced age. Here, we performed a metagenomics-based enterotype...
Pharmacological inhibition of ENaC or NCX can attenuate hepatic ischemia-reperfusion injury exacerbated by hypernatremia [0.03%]
通过药理学抑制ENaC或NCX可以缓解高钠血症加重的肝缺血再灌注损伤
Yabin Chen,Hao Li,Peihao Wen et al.
Yabin Chen et al.
Donors with a serum sodium concentration of >155 mmol/L are extended criteria donors for liver transplantation (LT). Elevated serum sodium of donors leads to an increased incidence of hepatic dysfunction in the early postoperative period of...
Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis [0.03%]
类风湿关节炎和牙周病关系的流行病学和病理发病机制
Huiya Fang,Jin Lin,Yiwu Qiu et al.
Huiya Fang et al.
Rheumatoid arthritis (RA), an autoimmune disease characterized by chronic inflammation of synovial tissue, is divided into two subtypes-anti-citrullinated protein antibody (ACPA)-positive and ACPA-negative RA. While the pathogenic mechanism...
Treatment of large bone defects in load-bearing bone: traditional and novel bone grafts [0.03%]
负重骨骼大型骨缺损的治疗：传统与新型骨移植材料
Dan Yu,Wenyi Shen,Jiahui Dai et al.
Dan Yu et al.
Large bone defects in load-bearing bone can result from tumor resection, osteomyelitis, trauma, and other factors. Although bone has the intrinsic potential to self-repair and regenerate, the repair of large bone defects which exceed a cert...
Ruofan Jin,Ruhong Zhou,Dong Zhang
Ruofan Jin
Antibodies currently comprise the predominant treatment modality for a variety of diseases; therefore, optimizing their properties rapidly and efficiently is an indispensable step in antibody-based drug development. Inspired by the great su...
Functional redundancy of three mitochondrial Mg2+/Mn2+-dependent protein phosphatases (PPMs) in Toxoplasma gondii [0.03%]
托拉川原虫中三种线粒体Mg2+/Mn2+-依赖性蛋白磷酸酶的功能冗余性
Kaiyin Sheng,Xueqiu Chen,Yimin Yang et al.
Kaiyin Sheng et al.
Toxoplasma gondii is a single-celled parasite that infects nearly all warm-blooded animals, including humans (Montoya and Liesenfeld, 2004). It occurs worldwide and can persist for a lifetime in mammals. Humans get infected by eating underc...
Dynamic changes in physiochemical, structural, and flavor characteristics of ginger-juice milk curd [0.03%]
生姜汁牛奶凝固物的理化、结构和风味特性的动态变化
Haifeng Pan,Wenna Bao,Yi Chen et al.
Haifeng Pan et al.
Dynamic changes in the physiochemical, structural, and flavor characteristics of ginger-juice milk curd were explored by texture analysis, scanning electron microscopy, rheometry, electronic tongue, and gas chromatography-mass spectrometry ...
Single-cell and spatial transcriptomic analysis reveals that an immune cell-related signature could predict clinical outcomes for microsatellite-stable colorectal cancer patients receiving immunotherapy [0.03%]
单细胞和空间转录组分析揭示免疫细胞相关标志物可预测微卫星稳定型结直肠癌患者接受免疫治疗的临床结局
Shijin Yuan,Yan Xia,Guangwei Dai et al.
Shijin Yuan et al.
Recent data suggest that vascular endothelial growth factor receptor inhibitor (VEGFRi) can enhance the anti-tumor activity of the anti-programmed cell death-1 (anti-PD-1) antibody in colorectal cancer (CRC) with microsatellite stability (M...