Selenocystine-based fluorescence assay combined with structural prediction for functional analysis of cystine transporter variants in cystinuria [0.03%]
基于硒半胱氨酸的荧光测定法结合结构预测用于半胱胺转运蛋白变异体的功能分析及半胱胺尿症研究
Xiaobai He,Xinyi Qian,Xiaoguang Zheng et al.
Xiaobai He et al.
Objectives: Cystine stones account for 1%‒2% of adult and up to 10% of pediatric kidney stones. They result from cystinuria, an autosomal recessive disorder caused by mutations in solute carrier family 3 member 1 (SLC3A1...
Machine learning-driven evaluation of protein kinase D3 as a co-diagnostic biomarker in hepatocellular carcinoma [0.03%]
机器学习驱动的蛋白激酶D3作为肝细胞癌共诊断生物标志物的评估
Jing Li,Yifan Zhao,Yicheng Ma et al.
Jing Li et al.
To elucidate the diagnostic value and clinical relevance of protein kinase D3 (PRKD3) in hepatocellular carcinoma (HCC), we analyzed data retrieved from The Cancer Genome Atlas (TCGA) database, which revealed high expression of PRKD3 in HCC...
DNA-based one-pot rapid biosensing platform integrating turn-back loop primer-accelerated LAMP and Pyrococcus furiosus Argonaute for meat visual authentication [0.03%]
基于DNA的一锅快速生物传感平台集成发夹启动子加速LAMP和Pyrococcus furiosus Argonaute肉品可视化认证
Sheng Ding,Jing Li,Minglong Yang et al.
Sheng Ding et al.
Meat adulteration is a significant global food safety challenge, creating a pressing need for rapid and on-site detection technologies. Herein, we present an intelligent one-pot biosensing platform termed one-pot TLAMP-PfAgo assay (OTPA) th...
Dual-functional nanoplatform for simultaneous degradation of circRNA CDR1as and real-time monitoring of miR-7 in live cells [0.03%]
一种用于活细胞中同时降解circRNA CDR1as和实时监测miR-7的双重功能型纳米平台
Yan Huang,Jialin Ye,Lan Xu et al.
Yan Huang et al.
Circular RNAs (circRNAs) are key post-transcriptional regulators with critical roles in pathogenesis, yet existing tools for their precise manipulation and functional analysis in living cells remain to be developed. A compelling therapeutic...
Advances in biomarkers for Parkinson's disease: from molecular pathology to precision diagnostics [0.03%]
帕金森病生物标志物研究进展：从分子病理学到精准诊断
Xiang Li,Honglin Chen,Xu Wang et al.
Xiang Li et al.
Parkinson's disease (PD) is the second most common neurodegenerative disorder, and continues to present significant challenges in early diagnosis, precise subtyping, and prognosis assessment. In recent years, the field of biomarker research...
Blood‒brain barrier permeability assessment: from biomimetic models to multimodal imaging [0.03%]
从仿生模型到多模式成像的血脑屏障通透性评价方法评估
Miaomiao Wang,Lu Gan,Yiru Fan et al.
Miaomiao Wang et al.
The blood‒brain barrier (BBB) is a vital physiological structure that maintains the microenvironmental homeostasis in the central nervous system (CNS). Imbalances in its permeability play a key role in various neurological disorders, inclu...
Programmable DNAzyme nanocatalysts for tumor immunometabolic modulation [0.03%]
可用于肿瘤免疫代谢调控的DNA酶纳米催化剂
Rongping Luo,Zhuojia Tang,Mengqi Ding et al.
Rongping Luo et al.
Programmable RNA-cleaving DNAzymes (RCDs) represent a unique class of catalytic nucleic acids that couple molecular recognition with enzyme-like activity. While DNAzymes have traditionally been explored for targeted gene regulation, recent ...
Wen Zhang,Yundong Hang,Sisi Zhan et al.
Wen Zhang et al.
Bacterial infections remain a significant threat to public health worldwide, driving an urgent need for rapid, accurate, and field-deployable diagnostic techniques. Point-of-care testing (POCT) has emerged as a transformative strategy, prov...
Intelligent biosensing and point-of-care testing: from molecular recognition to decentralized precision care [0.03%]
智能生物传感和即时检测：从分子识别到分散精准医疗
Jixi Zhang,Yi Zhang
Jixi Zhang
Point-of-care testing (POCT) is changing the way diagnostic information is generated, interpreted, and used. Its value extends well beyond shortening turnaround time. A meaningful POCT result should support a defined clinical or public-heal...
Halotolerant plant growth-promoting bacteria Enterobacter sp. Av16 and Acinetobacter sp. Av23 enhance seed germination and seedling photosynthesis of Apocynum pictum under salt stress [0.03%]
耐盐促生菌Enterobacter sp. Av16和Acinetobacter sp. Av23提高盐胁迫下白狗木种子萌发及幼苗光合性能
Xue Wang,Li Jiang,Yao Ge et al.
Xue Wang et al.
Apocynum pictum Schrenk, a halophyte, is commonly used as a traditional Chinese medicine, tea, and fiber crop. To improve the growth of A. pictum in saline soil, its responses to halotolerant plant growth-promoting bacteria (PGPB) were inve...