From Structural Complementarity to Functional Synergy: Advantages and Challenges of Combining Demineralized Dentin Matrix and Hydrogels for Bone Defect Repair [0.03%]
从结构互补到功能协同作用：脱矿牙本质基质和水凝胶结合修复骨缺损的优势与挑战
Bochen Guo,Yifan Wang,Jie Gao et al.
Bochen Guo et al.
Demineralized dentin matrix (DDM) provides intrinsic bioactivity and osteoinductive cues for bone regeneration but is limited by its rigidity and material heterogeneity. Advances in hydrogel engineering-encompassing biomimetic polymers and ...
Engineered Probiotic Saccharomyces boulardii Produces Functional Insulin With Long-Acting Effect in Mice Model [0.03%]
工程酵母酿酒活性干酵母产生功能性胰岛素并用于小鼠模型中研究其长效作用机制
Jefferson J Feng,Di Yu,Lydia Nyasae et al.
Jefferson J Feng et al.
Diabetes mellitus affects over 500 million people globally, with current insulin therapies relying on subcutaneous injections that compromise the liver's natural role in glucose regulation and suffer from poor patient compliance. Oral insul...
Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Loaded with Emodin Alleviate Intestinal Injury in Acute Pancreatitis [0.03%]
人源脐带间充质干细胞源性外泌体装载黄连素可减轻急性胰腺炎相关肠损伤
Siyao Liu,Zhihong Xu,Xiong Liu et al.
Siyao Liu et al.
Acute pancreatitis (AP)-induced intestinal barrier disruption drives fatal systemic complications. We engineered human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hUC-MSC-EVs) to deliver emodin-a bioactive compound ...
CREG1 Attenuates Osteoarthritis Progression by Suppressing Chondrocyte Pyroptosis Through the PINK1/Parkin-Mediated Mitophagy Pathway [0.03%]
CREG1通过PINK1/Parkin介导的线粒体自噬途径抑制软骨细胞焦亡从而减轻骨关节炎进展
Xianming Fei,Shuanggong Liu,Guangxu Song et al.
Xianming Fei et al.
Background: Osteoarthritis (OA) is a progressive degenerative disorder driven by complex pathogenic mechanisms. Increasing evidence indicates that NLRP3 inflammasome-mediated chondrocyte pyroptosis contributes critically ...
Molecular Genetics as the Leading-Edge Approach in Driving the Development of Live Attenuated Vaccines [0.03%]
分子遗传学在减毒活疫苗研发中的前沿作用
Ramesh Thevendran,Solayappan Maheswaran
Ramesh Thevendran
Molecular genetics has propelled advancements in scientific instrumentation, yielding transformative discoveries from CRISPR-mediated gene editing and detailed protein identification to sophisticated biosensor fabrications. This profound sh...
Application of Targeted Sequence Capture (TSC) for Genetic Characterization of Antibody Producing Cell Lines [0.03%]
目标序列捕获技术在抗体产生细胞系遗传特征分析中的应用研究
Sofie A O&#x;Brien,Jake T Leinas,Jodi Grantham et al.
Sofie A O&#x;Brien et al.
Genetic stability is an important attribute of biotherapeutic production cells, and as such, regulatory agencies require that production cell lines exhibit genetic comparability throughout the entire manufacturing process when applying for ...
Enhanced Biomedical and Photocatalytic Capabilities of Biosynthesized Zinc Oxide Nanoparticles Using Pistacia khinjuk Plant Extract [0.03%]
利用Pistacia khinjuk植物提取物增强生物合成的氧化锌纳米颗粒的生物医学和光催化性能
Ali Raza Kashif,Muhammad Usama Younas,Farasat Haider et al.
Ali Raza Kashif et al.
Nanotechnology presents tackling diverse difficulties across numerous domains, including environmental remediation, catalysis, and medicine. This study adopted an ultrasonic-assisted technique to synthesize ZnO nanoparticles from Pistacia k...
Enhancing DNAzyme Silencing via Phosphorothiolation to Reduce the Mg2+-Dependence [0.03%]
通过磷硫化增强DNA酶沉默以减少Mg2+依赖性
Zhongchun Zhou,Wen Sun,Xiang Gu et al.
Zhongchun Zhou et al.
817 DNAzyme has emerged as a potent catalytic nucleic acid tool for gene expression silencing, offering distinct advantages including programmable target recognition, enzymatic turnover capability, and high biostability. Despite its therape...
Mycoponics: Controlled Bioproduction Utilizing Biophysical, Solid-State, Liquid Nutrient Delivery [0.03%]
Myponics：利用生物物理的固态和液态营养输送进行受控生物生产
D Marshall Porterfield,Simone X Moulton,Adriana K Sanchez et al.
D Marshall Porterfield et al.
Mycoponic biotechnology, inspired by hydroponics-a vital technology for agriculture research and space exploration, is limited by innate substrate contamination commonplace in commercial mycoproduction. Using micro-structured ceramic tubes ...
Multidimensional Engineering of Saccharomyces cerevisiae for Efficient Production of Retinol [0.03%]
用于有效生产视黄醇的酿酒酵母(Saccharomyces cerevisiae)多维工程化改造
Minxia Song,Jiaheng Liu,Xianhao Xu et al.
Minxia Song et al.
Retinol, the major active form of vitamin A, plays a crucial role in vision, immune function, and skin health. The industrial model yeast Saccharomyces cerevisiae (S. cerevisiae) inherently possesses the mevalonate pathway, which supplies p...