Engineering Modification for the Efficient Synthesis of β-ionone by Yarrowia lipolytica [0.03%]
用于高效合成β-离子酮的假丝酵母工程改造
Kai Gu,Ping Lin,Guocheng Du et al.
Kai Gu et al.
β-Ionone, prized for its characteristic violet aroma and woody undertones, has emerged as a valuable ingredient in the fragrance industry. Beyond its aromatic qualities, growing interest in its diverse biological activities has positioned ...
A New Conditional Transcription Factor for Use in Toxoplasma Gondii [0.03%]
一个新的条件型转录因子在诱导子裂殖殖子里虫中的使用
Mohammad Farouq Sharifpour,Shadi Khadiv,Alessandro D Uboldi et al.
Mohammad Farouq Sharifpour et al.
Toxoplasma gondii is an intracellular eukaryotic parasite in the phylum Apicomplexa. Reversible, conditional control of gene transcription was achieved previously in this organism using a tet-off system that was controlled by tetracycline. ...
Lactiplantibacillus plantarum Z6 Improves Functional Constipation in Infants [0.03%]
婴儿植物乳杆菌Z6改善功能性便秘
Xiaoni Zhou,Gang Hu,Jingwu Wu et al.
Xiaoni Zhou et al.
Objective: To evaluate the efficacy and safety of Lactiplantibacillus plantarum Z6 (L. plantarum Z6) supplementation in infants with functional constipation (FC) and to explore its effects on gut microbiota composition. ...
Randomized Controlled Trial
Biotechnology journal. 2026 May;21(5):e70233. DOI:10.1002/biot.70233 2026
Multi-Machine Learning Elucidates Clinical Potential of Epithelial-Mesenchymal Transition-Associated Long Non-Coding RNAs in Breast Cancer Progression [0.03%]
多机器学习阐明上皮间质转化相关长链非编码RNA在乳腺癌进展中的临床潜力
Rui Zhu,Yi Li,Jiaxi Zhang et al.
Rui Zhu et al.
Breast carcinoma (BRCA) involves multiple molecular markers, including epithelial-mesenchymal transition (EMT), which induce cell migration. However, the specific impact of long non-coding RNAs (lncRNAs) on EMT in BRCA remains uncertain. In...
Biocatalytic Bamberger Rearrangement for the Synthesis of 3-Amino-2-hydroxyacetophenone via Hydroxylaminobenzene Mutase Engineering and Multi-Enzyme System Assembly [0.03%]
羟基氨苯甲酶工程及多酶系统组装驱动的生物催化Bamberger重排合成3-氨基-2-羟基乙酰苯酮
Heng Tang,Tian-Tian Guo,Jin-Xing Zhong et al.
Heng Tang et al.
The Bamberger rearrangement is a key route to functionalized aminophenols that are widely used in pharmaceutical synthesis. Hydroxylaminobenzene mutase (HabM) catalyzes a Bamberger-type isomerization in the biosynthesis of the Pranlukast in...
Capacitance Technology Enables Automated Feeding, Improved Expansion, and Higher Throughput of CAR-T Cell Stirred-Tank Bioreactor Cultures [0.03%]
电容技术使CAR-T细胞搅拌生物反应器培养实现自动化喂养、改善增殖和提高通量
Ivano Luigi Colao,Jacob Cunningham,Matthew Lee et al.
Ivano Luigi Colao et al.
Chimeric antigen receptor (CAR) T cells present a novel and transformative approach to treat certain haematological malignancies. However, CAR-T cell expansion methods are still under development and often rely on manual, low-control cultur...
Analytical Centrifugal Ultrafiltration as a Tool for High Throughput Process Development in Virus Removal Filtration [0.03%]
分析性离心超滤在病毒去除过滤高通量工艺开发中的应用研究
Sebastien Maffeis,Yuliia Fomichova,Levon Manukyan et al.
Sebastien Maffeis et al.
Virus removal filtration constitutes an essential component in biopharmaceutical manufacturing processes for both recombinant and plasma-derived protein products. The increasing demand for protein-based therapies necessitates expedited anal...
Multi-omics Analysis Reveals the Correlation of Gut Microbiota and Metabolites With Thalidomide Treatment for Chemotherapy-Induced Nausea and Vomiting in Small Cell Lung Cancer [0.03%]
多组学分析揭示肠道微生物组和代谢物与化疗诱导的恶心呕吐地尔硫卓治疗的小细胞肺癌的相关性
Qiang-Guo Sun,Dan Zang,Yu Xin et al.
Qiang-Guo Sun et al.
Small cell lung cancer (SCLC) is a highly aggressive malignancy, and chemotherapy frequently causes nausea and vomiting, which can impair treatment tolerance. Because thalidomide (THD) has shown potential clinical benefit in alleviating nau...
Production of (R)-1,3-butanediol via an Isozyme co-expression Strategy in Escherichia coli [0.03%]
通过同工酶共表达策略在大肠杆菌中生产(R)-1,3-丁二醇
Huifang Zhang,Dong Peng,Pinzhou Chen et al.
Huifang Zhang et al.
Microbial cell factories for the production of valuable chemicals often require multi-step biosynthetic pathways, whose efficiency is frequently limited by the performance and compatibility of pathway enzymes. Here, an isozyme co-expression...
Advanced Extractables and Leachables Assessment of Microcarriers Used for Adherent Cell Cultures [0.03%]
用于贴壁细胞培养的微载体的高级可提取物和浸出物评估
Armin Hauk,Ina Pahl,Jonas Austerjost et al.
Armin Hauk et al.
The study outlines principles and workflows for a comprehensive extractables and leachables qualification trial of microcarriers for use in a cell therapy application. Styrene-based MCs were qualitatively and quantitatively analyzed in acco...