A CD44-Targeted TLR7/8 Nanovaccine for Synergistic Photothermal Immunotherapy [0.03%]
一种针对CD44的TLR7/8纳疫苗联合光热免疫疗法
Raju Vivek,Namratha Parthasarathy,Babu Rithisa et al.
Raju Vivek et al.
Cancer continues to remain challenging due to heterogeneity and therapeutic resistance. Conventional therapeutic approaches, such as surgery, chemotherapy, and radiotherapy, often encounter critical limitations such as extensive tissue dama...
Exploring the Dual Action of Bimetallic CuO-ZnO Nanoparticles: A Green Approach to Combatting Bacteria and Vector Mosquitoes [0.03%]
CuO-ZnO双金属纳米粒子的双重抗菌抗蚊作用研究：一种绿色防控策略
Tharwat A Selim,Nosiba S Basher,Nawal E Al-Hazmi et al.
Tharwat A Selim et al.
This study investigated the biosynthesis of nanoparticles utilizing orange peel extract (OPE) to synthesize monometallic CuO and ZnO nanoparticles, in addition to bimetallic CuO-ZnO nanoparticles. A comparative examination was performed to ...
Toward Machine Learning-Guided CHO Bioprocess and Media Optimization for Improved Titer and Glycosylation [0.03%]
面向机器学习指导的CHO生物过程和培养基优化以提高滴度和糖基化水平
Ian Walsh,Fumi Shozui,Ayaka Sato et al.
Ian Walsh et al.
Precise control of critical quality attributes, including titer and glycosylation, is essential in bioprocessing, yet conventional design‑of‑experiments methods are challenged by the high-dimensional, nonlinear design space for media and ...
Advancements in CRISPR-Mediated Multiplex Genome Editing: Transforming Plant Breeding for Crop Improvement and Polygenic Trait Engineering [0.03%]
基于CRISPR的多重基因组编辑研究进展：作物育种改良及多基因性状工程改造中的应用及其前景展望
Uday Kumar,Dyumn Dwivedi,Uddalak Das
Uday Kumar
With accelerating climate change and the urgent need to stack polygenic traits, multiplex CRISPR/Cas offers a scalable route to resilient crops-yet low editing efficiency and regeneration bottlenecks remain critical constraints. This review...
Application of Nano-Drug Delivery Systems in Lung Cancer Diagnosis and Treatment [0.03%]
纳米药物递送系统在肺癌诊断和治疗中的应用
Leyi Tian,Xiaoyu Wang,Ying Chen et al.
Leyi Tian et al.
Lung cancer remains one of the leading causes of morbidity and mortality, highlighting the urgent need for innovative approaches to improve diagnosis and treatment outcomes. Nano-drug delivery systems (NDDSs) exhibit high surface-to-volume ...
Enhancing Carbon Metabolic Flow Ability for Titer Improvement of L-Lactic Acid in Bacillus coagulans Through Heavy Ion Mutagenesis [0.03%]
利用重离子诱变增强凝结芽孢杆菌碳代谢流能力以提高乳酸产量
Weibin Ma,Wenwen Shan,Jihong Chen et al.
Weibin Ma et al.
Bacillus coagulans is a preferred producer for lactic acid, still facing the challenge of poor carbon metabolic flow ability. Here, an engineered B. coagulans strain P14 with improved carbon metabolic flow ability was developed for the firs...
mRNA Stability: An Unresolved Challenge for Broad Therapeutic Applications [0.03%]
挑战性的信使RNA稳定性问题及其在治疗学中的应用
Yiming Wang,Xiaoxue Wang,Yuan Lu
Yiming Wang
From infectious diseases and cancers to various rare diseases, mRNAs have demonstrated considerable therapeutic potential for a wide range of diseases. However, due to their single-stranded structure, mRNA molecules are vulnerable to enzyme...
Overexpression of Matriptase-1 Inhibitor HAI-1 as an Effective Strategy to Reduce Proteolytic Clipping in Chinese Hamster Ovary Cells [0.03%]
过表达单相特异抑制因子HAI-1可有效降低CHO细胞中蛋白酶剪切现象发生率
Qinghao Zhang,Fnu Aapjeet,Joyce Chen et al.
Qinghao Zhang et al.
Proteolytic degradation of recombinant proteins in Chinese hamster ovary (CHO) cells remains a major challenge in biopharmaceutical manufacturing, often reducing product yield and quality. Matriptase-1, a type II transmembrane serine protea...
Modulation of Antibody Glycosylation in Chinese Hamster Ovary Cells: Experimental and Computational Analyses Provide Mechanistic Insights [0.03%]
中国地鼠卵巢细胞中抗体糖基化的调节：实验和计算分析提供了机制见解
Ranya Pranomphon,Sofia Gialamoidou,Montarop Yamabhai et al.
Ranya Pranomphon et al.
Process conditions and cell culture media components significantly impact glycosylation in ways that are still poorly understood. Here, we evaluated the glycan distribution of CHO-K1 clones producing adalimumab, a biosimilar version of the ...
Efficient Agrobacterium-Mediated Transformation of Green Arabidopsis Suspension Cells [0.03%]
绿色拟南芥悬浮细胞的高效农杆菌介导转化体系
Matthias Buntru,Stefano Di Fiore,Nils Hahnengress et al.
Matthias Buntru et al.
Photosynthetic plant cell suspension cultures are a valuable experimental system for analyzing various physiological processes. This system bypasses the structural complexity of the whole plant organism and can be manipulated under uniform ...