Exploring Indole-1,3,4-Thiadiazole Schiff Base Derivatives as Anticancer Agents: Design, Synthesis, In Vitro and In Silico Evaluation [0.03%]
作为抗癌剂的吲哚-1,3,4-噻二唑希夫碱衍生物的研究：设计，合成以及体内外评价
Umadevi Etikyala,Rajkumar Reddyrajula,Udaya Kumar Dalimba et al.
Umadevi Etikyala et al.
Cancer remains a major global health challenge, with resistance to existing therapeutic regimens underscoring the development of novel agents with improved efficacy and reduced toxicity. The indole and 1,3,4-thiadiazole scaffolds are distin...
A Dual-Emissive Lanthanide Organic light-emitting diode for Single-Pixel Pulse Oximetry: From Molecular Design to Device-Level Integration [0.03%]
兼具双发射特性的稀土有机发光二极管单像素脉搏血氧仪：从分子设计到器件集成
Andrey I Kornikov,Makarii I Kozlov,Andrey A Vashchenko et al.
Andrey I Kornikov et al.
Organic light-emitting diodes (OLEDs) with dual emission in the red and near-infrared regions offer a breakthrough opportunity for simplifying pulse oximetry technology. Here, a new class of bimetallic complexes Eu0.1Yb0.9(L)3Q (L = β-dike...
Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential [0.03%]
用于急性镰状细胞病治疗的强力抗凝固呋喃甲醛类似物：功效增强和静脉内配方潜力
Abdelsattar M Omar,Moustafa E El-Araby,Tarek A Ahmed et al.
Abdelsattar M Omar et al.
Sickle cell disease (SCD) is a debilitating inherited blood disorder characterized by acute crises that require immediate intervention. Aromatic aldehydes that increase hemoglobin (Hb) oxygen affinity (e.g., 5-HMF) can prevent hypoxia-induc...
Jan Birringer,Johannes Konrad,Stephan Melchner et al.
Jan Birringer et al.
Photo-labile protecting groups (PPG) allow for the selective activation of an originally caged moiety by light exposure at a specific wavelength. Incorporation of PPG in nanoparticles (NPs) enables precise spatiotemporal control over NPs su...
Enhancing Stability and Entrapment Efficiency of Liposome-Coated Mesoporous Silica Nanocarriers Using Polyoxyethylene Alkyl Ether as a Polyethylene Glycol Anchoring Agent [0.03%]
聚氧乙烯烷基醚作为聚乙二醇接枝剂增强脂质体包裹介孔硅纳米载体稳定性和载药量的研究
Tien-Dung Nguyen-Dinh,Ngoc Hoi Nguyen,Tan Phat Nguyen et al.
Tien-Dung Nguyen-Dinh et al.
The development of a phospholipid bilayer coating on the nanoparticle surface, particularly mesoporous nanosilica (MSN), has recently emerged as a promising strategy in drug delivery systems. However, the strong interactions of the phosphol...
Delivery of a GPX4 Inhibitor by SN38 Prodrug Nanoassemblies for Amplified Antitumor Efficacy Based on Ferroptotic Chemotherapy [0.03%]
基于铁死亡化疗的GPX4抑制剂递送：用于增强抗肿瘤功效的SN38前药纳米组装体
Lin Li,Yanyan Wu,Weiwei Wang et al.
Lin Li et al.
Prodrug-based self-assembled nanoassemblies, with carrier-free structures and high drug loading, are garnering attention for chemotherapy. Additionally, the synergistic effects of prodrug nanoassemblies combined with multiple cell death pat...
API-ILs Ionic Adducts: Solubility and Surface Activity Properties-En Route to New Paradigm in Drug Development [0.03%]
药物开发新范式之路——离子加合物的溶解性和表面活性性质研究
Janusz Nowicki,Marian M Zgoda,Marcin Muszyński et al.
Janusz Nowicki et al.
Two novel, structurally different perfluoroalkyl ionic liquids with bicyclic guanidinium cation have been synthesized and applied as a surfactant component for selected active pharmaceutical ingredients (APIs). The addition of perfluoroalky...
A Warm Welcome to MedChem: The Frontiers in Medicinal Chemistry 2025 [0.03%]
《药化暖 welcome：2025年药化前沿》
Matthias Schiedel,Marta Pinto,Andrea Unzue Lopez et al.
Matthias Schiedel et al.
The Frontiers in Medicinal Chemistry (FiMC), which represents the largest international Medicinal Chemistry conference in Germany, took place from April 1st to 4th, 2025, in Erlangen. The conference was a great success, bringing together mo...
Benzoxazole Derivatives as Dual p38α Mitogen-Activated Protein Kinase and Acetylcholinesterase Inhibitors: Design, Synthesis, and Evaluation for Alzheimer's Disease and Cancer Therapy [0.03%]
苯并恶唑衍生物作为p38α丝裂原活化蛋白激酶和乙酰胆碱酯酶双重抑制剂的设计、合成及评价：阿尔茨海默病和癌症治疗中的应用研究
Bayan Zoatier,Gizem Yildiztekin,Mehmet Abdullah Alagoz et al.
Bayan Zoatier et al.
Alzheimer's disease (AD), the most prevalent form of dementia, leads to progressive cognitive decline due to pathological hallmarks including amyloid plaques, neurofibrillary tangles, synaptic loss, neuroinflammation, and neuronal cell deat...
Synthesis of Tacrine/Amiridine Conjugates with Aminomethylidene Derivatives of Trifluoroacetoacetic Ester and their Biological Potential for the Therapy of Alzheimer's Disease [0.03%]
三氟乙酸酯氨基甲基衍生物与氨甲苯并四氢吡啶共轭物的合成及其治疗阿尔茨海默病的生物潜能研究
Maria V Grishchenko,Galina F Makhaeva,Yanina V Burgart et al.
Maria V Grishchenko et al.
To assess the influence of the nature of the anticholinesterase pharmacophore on the properties of potential multitarget Alzheimer's disease (AD) agents, new conjugates of tacrine (3a, b) and amiridine (5a, b) with ethyl-2-aminomethylidene-...