Synthesis and Antifungal Activity of 4-Arylamino-1,2-Naphthoquinones-1,2,3-Triazoles Hybrids [0.03%]
Acácio Silva de Souza,Gabriel Nogueira da Silva,Iva Souza de Jesus et al.
Acácio Silva de Souza et al.
Quinones have been strategically combined with various heterocyclic scaffolds to enhance their biological properties. In this study, two new series of hybrid derivatives of 4-amino-1,2-naphthoquinones bearing a triazole ring were synthesize...
Anneli Nordqvist,Bo Lindmark,Kenneth L Granberg et al.
Anneli Nordqvist et al.
Mineralocorticoid receptor (MR) antagonists play a vital role in the management of conditions such as heart failure and hypertension. The recent approval of finerenone for diabetic kidney disease, along with expanding opportunities to treat...
Discovery and Evaluation of 6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Derivatives as P-gp Inhibitors to Overcome Multidrug Resistance in Eca109/VCR Cells [0.03%]
Wen-Jing Lai,Chun-Ling Guo,Jin-Yu Xia et al.
Wen-Jing Lai et al.
The efficacy of chemotherapy against malignant tumors is severely limited by multidrug resistance (MDR), of which the overexpression of P-glycoprotein (P-gp) is recognized as a key mechanism. Consequently, the development of potent, low-tox...
Synthesis of 2-Aryl(alkyl)benzimidazole Hydroxamic Acids as HDAC Inhibitors with Anti-Angiogenesis Properties [0.03%]
Yi-Ting Liu,Cheng-Ta Lai,Shih-Wei Wang et al.
Yi-Ting Liu et al.
This study synthesized a series of C2 and N1-substituted benzimidazole hydroxamic acid (6-19) as HDAC inhibitors. Among them, most of 2-aryl(alkyl)benzimidazole hydroxamic acids (11-16) exhibited HDAC6 activity and slight HDAC1 (or HDAC2) a...
On-Demand Inhibition of Ciprofloxacin's Activity by Cucurbit[7]uril Supramolecular Chemistry [0.03%]
Delong Hou,Chengcheng Wang,Demeng Liu et al.
Delong Hou et al.
On-demand inhibition of antibiotic activity presents a promising strategy to mitigate the growing risk of antimicrobial resistance, a major challenge in modern therapeutics. Herein, we demonstrate a supramolecular strategy for the on-demand...
Exploring 6-Hydroxy-3-Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi [0.03%]
C N Pereira,L da Silva Lara,S da Costa Lanera et al.
C N Pereira et al.
Chagas disease urgently requires the development of new, safe, and effective therapies. We evaluated a series of 6-hydroxy-3-aryl/heteroarylcoumarin derivatives against Trypanosoma cruzi to identify candidates with multistage activity. Our ...
Copper(II)-Tripeptide Complexes as Potential Skin Healing Agents: Synthesis, Characterization, and Wound Repair Ability [0.03%]
Lorena Aguilar,Emiliano Garcia Gabastú,Mateo Schaffner et al.
Lorena Aguilar et al.
Due to the rising incidence of skin diseases, the World Health Organization has emphasized the need for improved prevention and treatment strategies. The search for new compounds active against skin lesions and pathologies has attracted sig...
Synergy of Bacterial Lipid Liposomes and Monoterpene-Mediated Membrane Perturbation for Enhanced Intracellular Mycobacteria Eradication and Biofilm Disruption [0.03%]
细菌脂质体与单萜介导的膜扰动协同作用增强胞内分枝杆菌根除和生物被膜破坏的研究
Nishant Pandey,Kaustav Mondal,Shivam Sharma et al.
Nishant Pandey et al.
In this work, we created liposomes using lipids from the outer membrane layer of Mycobacterial smegmatis (Msm) and doped them with rifampicin and lipophilic terpene, limonene, resulting in a dual-loaded liposomal formulation. Limonene incor...
Allium-Derived Compounds Against Multidrug-Resistant Bacteria: Antibacterial Activity and Synergistic Effects [0.03%]
大蒜衍生成分对抗多重耐药菌的抗菌活性及协同作用研究
Antonio Sorlózano-Puerto,Yariel Figueroa-Vega,Pablo Martín-Valenzuela et al.
Antonio Sorlózano-Puerto et al.
Background and objectives: Antibiotic resistance is a major global health challenge, driven by misuse in medicine and agriculture and the scarcity of new drugs. Allium-derived organosulfur molecules have shown antimicrobi...
Evaluation of Active and Passive Targeting Drug Delivery Systems as a Mechanism to Improve the Anticancer Potential of Titanium(IV) [0.03%]
评估活性和被动靶向药物递送系统作为提高钛(IV)抗癌潜能的机制
Oscar Claudio-Ares,Mallesh Pandrala,Lauren Fernández-Vega et al.
Oscar Claudio-Ares et al.
Titanium(IV) compounds are promising anticancer agents, but their development is hindered by poor aqueous stability and/or inefficient cellular delivery. This study compares two Ti(IV) compounds with contrasting properties: titanocene-dichl...