Experimental and DFT studies on the regioselective methanolysis of 5-azido-9-oxabicyclo[6.1.0]nonan-4-yl 4-nitrobenzoate isomers [0.03%]
5-叠氮-9-氧杂 bicyclo[6.1.0]壬-4-基 4-硝基苯甲酸酯异构体的区域选择性甲醇解实验和DFT研究
İlknur Polat,Selçuk Eşsiz,Emine Salamci
İlknur Polat
The regioselective methanolysis of new azido-4-nitrobenzoate epoxycyclooctane isomers and the characterization of the resulting products are described herein. Firstly, treatment of key compound 8-azidocyclooct-4-en-1-ol with 4-nitrobenzoyl ...
Recent advances in the stereoselective synthesis of distal biaxially chiral molecules [0.03%]
远程双轴手性分子的立体选择性合成最新进展
Fanxing Zhou,Chen Zhang,Lingyu Sun et al.
Fanxing Zhou et al.
Molecules bearing 1,3-dual axial and more distal axial chiralities are widely applied in chiral ligands, natural products, and anticancer agents, with their unique spatial configurations endowing them with distinctive functions and values. ...
Synthesis of a HDAC inhibitor-nanogold probe for cryo-EM visualization in class I HDAC co-repressor complexes [0.03%]
组蛋白去乙酰化酶抑制剂-纳米金探针的合成及其在I类组蛋白去乙酰化酶共抑制物复合物中的低温emdetection可视化研究
Wiktoria A Pytel,John W R Schwabe,James T Hodgkinson
Wiktoria A Pytel
Class I histone deacetylases (HDACs 1-3) serve as catalytic subunits within seven multiprotein co-repressor complexes, each of which has distinct functions in the cell. We report the synthesis of a HDAC inhibitor-nanogold probe, derived fro...
Synthesis and uranyl(VI) extraction performance of a calix[4]pyrrole-tetrahydroxamic acid receptor [0.03%]
刚性四羟胺酸杯芳烃配体的合成及六价铀萃取性能研究
Sara Karnib,Rana Baydoun,Wissam Zaidan et al.
Sara Karnib et al.
The contamination of water by uranium poses a serious threat to ecosystems and human health, creating a need for efficient and selective remediation strategies. Supramolecular materials, with their pre-organized structures, offer a promisin...
Sebastian Dominik Graf
Sebastian Dominik Graf
Eribulin is a synthetic analog of halichondrin B, a natural product derived from marine sponges, and has gained significant importance in oncology (as its commercial mesylate salt, Halaven) due to its unique mechanism of action as a microtu...
A facile and practical method for the synthesis of trans-(±)-taxifolin and its derivatives via Darzens reaction [0.03%]
一种通过Darzens反应合成反式-(±)-杨梅素及其衍生物的简便方法
Bo Peng,Panpan Yang,Maaz Khan et al.
Bo Peng et al.
The synthesis of racemic trans-taxifolin (trans-(±)-taxifolin) and its derivatives and subsequent chiral separation is the most prevalent chemical method to obtain enantiomerically pure taxifolin and its derivatives. The development of an ...
Synthesis and stereochemical analysis of dynamic planar chiral oxa[7]orthocyclophene [0.03%]
动态平面手性的氧杂[7]正交环状烯烃的合成与立体化学分析
Yukiho Hashimoto,Yuuya Kawasaki,Kazunobu Igawa et al.
Yukiho Hashimoto et al.
Planar chiral C6-substituted oxa[7]orthocyclophenes were designed and synthesized, and their stereochemical behavior was analyzed. The Kumada-Tamao coupling of the C6-iodo-substituted oxacyclophene enabled the efficient and divergent synthe...
David Yu-Kai Chen,Chao Li,Yefeng Tang
David Yu-Kai Chen
Synthesis and anti-cancer activity of naphthalimide-organylselanyl conjugates [0.03%]
并四苯并咪唑与有机硒类化合物的构建及抗肿瘤活性研究
Rajkumar Ravi,Selvakumar Karuthapandi
Rajkumar Ravi
The structure-based approach remains a valuable tool for rapid and high-throughput drug discovery and lead optimisation. In this study, we report the in-silico modelling and anticancer activity of two 1,8-napthalimide (NAP) derivatives cont...
Cone p-aminocalix[4]arenes enriched with 'clickable' alkyne or azide functionalities [0.03%]
富电子的含"可点击"炔基或叠氮官能团的锥型p-氨甲川轮烯（Calix[4]arenes）化合物
Ilia Korniltsev,Vasily Bazhenov,Alexander Gorbunov et al.
Ilia Korniltsev et al.
Efficient approaches have been developed for the synthesis of heteromultifunctional cone calix[4]arenes containing four amino groups at the wide rim and one, two or four propargyl or 2-azidoethyl groups at the narrow rim of the macrocycle, ...