Direct trifluoroethylation of carbonyl sulfoxonium ylides using hypervalent iodine compounds [0.03%]
使用超价碘化合物直接三氟乙基化羰基亚砜亚胺
Radell Echemendía,Carlee A Montgomery,Fabio Cuzzucoli et al.
Radell Echemendía et al.
A novel study on the hypervalent iodine-mediated polyfluoroalkylation of sulfoxonium ylides was developed. Sulfoxonium ylides, known for their versatility and stability, are promising substrates for numerous transformations in synthetic che...
Shi Liu,Märt Lõkov,Sofja Tshepelevitsh et al.
Shi Liu et al.
Quantitative assessment of the first acidity constant (pK a) for BFC (27.6 in CH3CN) and FIC (27.8 in CH3CN) shows the methylene protons to be significantly more acidic than those in related cyclopentadiene (32 in CH3CN), indene (34 in CH3C...
Synthesis of extended fluorinated tripeptides based on the tetrahydropyridazine scaffold [0.03%]
基于四氢吡啶并恶唑框架的扩展氟化三肽合成
Thierry Milcent,Pascal Retailleau,Benoit Crousse et al.
Thierry Milcent et al.
The synthesis of tripeptides incorporating new fluorinated heterocyclic hydrazino acids, based on the tetrahydropyridazine scaffold is described. Starting from simple fluorinated hydrazones, these non-proteinogenic cyclic β-amino acids wer...
Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies [0.03%]
多组分反应在中枢神经系统疾病治疗药物发现和优化中的驱动作用
Lucía Campos-Prieto,Aitor García-Rey,Eddy Sotelo et al.
Lucía Campos-Prieto et al.
The ongoing quest to discover effective treatments for diseases remains a significant challenge for the scientific community. Multicomponent reactions (MCRs) have emerged as powerful tools in accelerating drug discovery, enabling the rapid ...
Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling [0.03%]
德国三唑作为CuAAC多样化和化学选择性正交交叉偶联的平台
John M Halford-McGuff,Thomas M Richardson,Aidan P McKay et al.
John M Halford-McGuff et al.
We report the synthesis of germanyl triazoles formed via a copper-catalysed azide-alkyne cycloaddition (CuAAC) of germanyl alkynes. The reaction is often high yielding, functional group tolerant, and compatible with complex molecules. The i...
Charu Bansal,Oliver Ruggles,Albert C Rowett et al.
Charu Bansal et al.
The chemistry of hypervalent iodine (HVI) reagents has gathered increased attention towards the synthesis of a wide range of chemical structures. HVI reagents are characterized by their diverse reactivity as oxidants and electrophilic reage...
Enantioselective regiospecific addition of propargyltrichlorosilane to aldehydes catalyzed by biisoquinoline N, N'-dioxide [0.03%]
生物异喹啉N，N-氧化物催化甲醛烯丙基三氯硅烷enantioselective regiospecific加成反应
Noble Brako,Sreerag Moorkkannur Narayanan,Amber Burns et al.
Noble Brako et al.
Distilled propargyltrichlorosilane with >99% isomeric purity was prepared for the first time, and its asymmetric catalytic regiospecific addition reaction to aldehydes was developed through a systematic catalyst structure-reactivity and sel...
Controlled oligomerization of [1.1.1]propellane through radical polarity matching: selective synthesis of SF5- and CF3SF4-containing [2]staffanes [0.03%]
利用自由基极性匹配控制轮烷的寡聚化反应：选择性合成含SF5和CF3SF4的[2]Staffane化合物
Jón Atiba Buldt,Wang-Yeuk Kong,Yannick Kraemer et al.
Jón Atiba Buldt et al.
Selectivity in radical chain oligomerizations involving [1.1.1]propellane - i.e., to make [n]staffanes - has been notoriously challenging to control when n > 1 is desired. Herein, we report selective syntheses of SF5- and CF3SF4-containing ...
Mandeep K Chahal
Mandeep K Chahal
This review provides an overview of recent progress made in the field of catalysis using metal-free tetrapyrrolic macrocycles, focusing on calix[4]pyrroles, porphyrins and corroles, which are structurally related to porphyrins. Calix[4]pyrr...
Synthesis of the 1,5-disubstituted tetrazole-methanesulfonylindole hybrid system via high-order multicomponent reaction [0.03%]
基于高阶多组分反应合成1,5-取代四氮唑甲磺酸吲哚杂环体系
Cesia M Aguilar-Morales,América A Frías-López,Nadia V Emilio-Velázquez et al.
Cesia M Aguilar-Morales et al.
A series of 1,5-disubstituted tetrazole-indole hybrids were synthesized via a high-order multicomponent reaction consisting of an Ugi-azide/Pd/Cu-catalyzed hetero-annulation cascade sequence. This operationally simple one-pot protocol allow...