Competitive cyclization of ethyl trifluoroacetoacetate and methyl ketones with 1,3-diamino-2-propanol into hydrogenated oxazolo- and pyrimido-condensed pyridones [0.03%]
乙基三氟乙酰乙酸乙酯和甲基酮与1,3-二氨基-2-丙醇竞争环合生成氢化氧杂和嘧啶稠合吡啶酮化合物
Svetlana O Kushch,Marina V Goryaeva,Yanina V Burgart et al.
Svetlana O Kushch et al.
The use of 1,3-diamino-2-propanol with competitive N- and O-nucleophilic centers in a three-component cyclization with ethyl 4,4,4-trifluoroacetoacetate and methyl ketones enables the synthesis to be carried out for octahydropyrido[1,2-a]py...
Tandem hydrothiocyanation/cyclization of CF3-iminopropargyl alcohols with NaSCN in the presence of AcOH [0.03%]
醋酸存在下CF3-亚氨基炔醇与NaSCN的串联氢硫氰酸化/环化反应
Ruslan S Shulgin,Ol&#x;ga G Volostnykh,Anton V Stepanov et al.
Ruslan S Shulgin et al.
The synthesis of trifluoromethylated isothiazolium thiocyanates and 4-thiocyanato-2,5-dihydrofurans is presented through hydrothiocyanation/cyclization of CF3-iminopropargyl alcohols using NaSCN in AcOH/MeCN. The formation of the two produc...
Mechanistic insights into hydroxy(tosyloxy)iodobenzene-mediated ditosyloxylation of chalcones: a DFT study [0.03%]
基于茋的双取代二碘化苯甲酸酯化合物的合成及光物理性质研究：密度泛函理论计算
Jai Parkash,Sangeeta Saini,Vaishali Saini et al.
Jai Parkash et al.
In this paper, the mechanism of the hydroxy(tosyloxy)iodobenzene (HTIB)-mediated conversion of chalcones (α,β-unsaturated carbonyl compounds) to ditosyloxy ketones is investigated. Here, at β-carbon of the chalcone, an aryl group with a ...
Total synthesis of asperdinones B, C, D, E and terezine D [0.03%]
asperdinones B、C、D、E和terezine D的全合成
Ravi Devarajappa,Stephen Hanessian
Ravi Devarajappa
The total synthesis of new members of prenylated indole alkaloids exhibiting α-glucosidase activity is described. Asperdinones B, C, D, and E are characterized by the presence of a (3R)-3-indolylmethylbenzodiazepine-2,5-dione unit at C-3 o...
Synthesis of new tetra- and pentacyclic, methylenedioxy- and ethylenedioxy-substituted derivatives of the dibenzo[ c, f][1,2]thiazepine ring system [0.03%]
具有甲叉二氧和乙叉二氧取代的并[1,2-a][1,2]噻唑平四环及五环新衍生物的合成研究
Gábor Berecz,András Dancsó,Mária Tóthné Lauritz et al.
Gábor Berecz et al.
New tetra- and pentacyclic derivatives of the dibenzo[c,f][1,2]thiazepine ring system have been synthesized. The target compounds contain methylenedioxy or ethylenedioxy substituents linked to the benzene ring. The key step for the construc...
Morwenna Mögel,David Berger,Philipp Heretsch
Morwenna Mögel
The Veratrum alkaloids constitute a class of natural products with particularly intricate polycyclic frameworks and dense stereochemistry and, thus, have stood long as benchmarks in chemical synthesis. Recently, these steroid alkaloids gain...
Chemoenzymatic synthesis of the cardenolide rhodexin A and its aglycone sarmentogenin [0.03%]
卡红碱A及其配糖体萨尔门若坚素的化学生物合成法研究
Fuzhen Song,Mengmeng Zheng,Dongkai Wang et al.
Fuzhen Song et al.
Herein, we report a concise chemoenzymatic synthesis of the cardenolide rhodexin A in 9 steps and the first protecting-group-free synthesis of its aglycone sarmentogenin in 7 steps from 17-deoxycortisone. The synthesis features a scalable e...
Thiazolidinones: novel insights from microwave synthesis, computational studies, and potentially bioactive hybrids [0.03%]
噻唑啶酮：来自微波合成、计算研究和潜在生物活性杂化物的新见解
Luan A Martinho,Victor H J G Praciano,Guilherme D R Matos et al.
Luan A Martinho et al.
Various 5-arylidene derivatives were prepared via a Knoevenagel condensation-type reaction of aromatic/heteroaromatic aldehydes with rhodanine or thiazolidine-2,4-dione (TZD) catalyzed by EDA/AcOH under microwave heating. This convenient me...
Silica gel with covalently attached bambusuril macrocycle for dicyanoaurate sorption from water [0.03%]
一种共价固定有巨环笼合物的硅胶水相吸附剂用于二氰 aurate 阳离子的富集与分离
Michaela Šusterová,Vladimír Šindelář
Michaela Šusterová
Anion removal from aqueous solutions remains a major challenge due to the strong hydration of anions. Here, we report the preparation of silica gel functionalized with covalently anchored bambusuril macrocycles. In aqueous solution, this ma...
Efficient solid-phase synthesis and structural characterization of segetalins A-H, J and K [0.03%]
segetalins A-h,j和k的高效固相合成及结构鉴定
Liangyu Liu,Wanqiu Lu,Quanping Guo et al.
Liangyu Liu et al.
This study establishes an efficient solid-phase strategy for the total synthesis of segetalins A-H, J and K (1-10), bioactive cyclopeptides isolated from Vaccaria segetalis. Linear precursors were assembled on cost-effective 2-chlorotrityl ...