New tandem Ugi/intramolecular Diels-Alder reaction based on vinylfuran and 1,3-butadienylfuran derivatives [0.03%]
基于乙烯基呋喃和1,3-丁二烯基呋喃衍生物的新串联Ugi/分子内Diels-Alder反应
Yuriy I Horak,Roman Z Lytvyn,Andrii R Vakhula et al.
Yuriy I Horak et al.
A new tandem sequence involving the Ugi reaction and Diels-Alder [4 + 2] cycloaddition based on vinylfuran and 1,3-butadienylfuran derivatives was designed and studied. It was found that in the case of 3-(furan-2-yl)acrylaldehyde, a one-pot...
Electrochemical synthesis of cyclic biaryl λ3-bromanes from 2,2'-dibromobiphenyls [0.03%]
2,2'-二溴联苯电化学合成环状茋溴烷衍生物
Andrejs Savkins,Igors Sokolovs
Andrejs Savkins
The remarkable nucleofugality of bromoarenes in diarylbromonium species renders them particularly suitable for the generation of arynes for subsequent use in a wide range of synthetic applications. The common approach to generate cyclic bia...
Beyond symmetric self-assembly and effective molarity: unlocking functional enzyme mimics with robust organic cages [0.03%]
超越对称自组装和有效浓度：利用坚固的有机笼释放功能性的酶模拟物
Keith G Andrews
Keith G Andrews
The bespoke environments in enzyme active sites can selectively accelerate chemical reactions by as much as 1019. Macromolecular and supramolecular chemists have been inspired to understand and mimic these accelerations and selectivities fo...
Photomechanochemistry: harnessing mechanical forces to enhance photochemical reactions [0.03%]
光力化学：利用机械力来促进光化学反应
Francesco Mele,Ana Maria Constantin,Andrea Porcheddu et al.
Francesco Mele et al.
Photomechanochemistry, i.e., the merger of light energy and mechanical forces, is emerging as a new trend in organic synthesis, enabling unique reactivities of fleeting excited states under solvent-minimized conditions. Despite its transfor...
Identification and removal of a cryptic impurity in pomalidomide-PEG based PROTAC [0.03%]
基于pomalidomide-PEG的PROTAC中隐性杂质的识别与去除
Bingnan Wang,Yong Lu,Chuo Chen
Bingnan Wang
Chemically induced dimerization is a powerful tool for studying protein function, wherein the IMiD (the "immunomodulatory drug") class of PROTAC molecules with a PEG linker is frequently used to promote targeted protein degradation. The sta...
Unraveling aromaticity: the dual worlds of pyrazole, pyrazoline, and 3D carborane [0.03%]
芳香性的揭秘：吡唑、吡唑啉和三维硼碳化合物的双重世界
Zahra Noori,Miquel Solà,Clara Viñas et al.
Zahra Noori et al.
A new series of o-carborane-fused pyrazoles has been recently successfully synthesized. This fusion was expected to create a hybrid 3D/2D aromatic system, combining the 3D aromaticity of o-carborane with the 2D aromaticity of pyrazole. Howe...
Synthesis, structure, ionochromic and cytotoxic properties of new 2-(indolin-2-yl)-1,3-tropolones [0.03%]
新的2-（吲哚啉-2-基）-1,3-托罗隆的合成，结构，离子色性和细胞毒性性质
Yurii A Sayapin,Eugeny A Gusakov,Inna O Tupaeva et al.
Yurii A Sayapin et al.
The acid-catalyzed reaction of benzo[e(g)] derivatives of 2,3,3-trimethylindolenines with o-chloranil leads to new 2-(benzo[e(g)]indolin-2-yl)-5,6,7-trichloro-1,3-tropolones and 2-(benzo[e(g)]indolin-2-yl)-4,5,6,7-tetrachloro-1,3-tropolones...
The effect of neighbouring group participation and possible long range remote group participation in O- glycosylation [0.03%]
邻近基团参与及可能的远程基团参与对O-糖基化的影响
Rituparna Das,Balaram Mukhopadhyay
Rituparna Das
Stereoselective glycosylations are one of the most challenging tasks of synthetic glycochemists. The protecting building blocks on the glycosides contribute significantly in attaining the required stereochemistry of the resulting glycosides...
Synthesis, characterization, antimicrobial, cytotoxic and carbonic anhydrase inhibition activities of multifunctional pyrazolo-1,2-benzothiazine acetamides [0.03%]
多功能的吡唑并[1,2- d][1,3]苯并噻嗪乙酰胺的合成，表征及抗微生物，细胞毒性以及碳酸酐酶抑制活性研究
Ayesha Saeed,Shahana Ehsan,Muhammad Zia-Ur-Rehman et al.
Ayesha Saeed et al.
The advent of antibiotic resistance in microorganisms requires the discovery and synthesis of novel antibiotics. At the same time, human pathogens are contributing to chronic and persistent inflammation. Motivated by these two concerning is...
Antibiofilm and cytotoxic metabolites from the entomopathogenic fungus Samsoniella aurantia [0.03%]
害虫病原真菌萨氏黄球孢子菌中的抗生物膜和细胞毒性代谢物
Rita Toshe,Syeda J Khalid,Blondelle Matio Kemkuignou et al.
Rita Toshe et al.
During the course of our studies on the secondary metabolism of rare, hitherto untapped Thai insect-associated fungi, the ethyl acetate (EtOAc) extract derived from solid-state cultivation of Samsoniella aurantia on rice afforded one previo...