Synthesis of functionalized, 13-alkyl-substituted coralyne derivatives and investigation of their interactions with duplex and abasic site-containing DNA [0.03%]
功能化13-烷基取代的珊瑚酮衍生物合成及其与双链和碱基对缺失位点含DNA相互作用研究
Laurin Beckmann,Jason Lennard Kunze,Hannah Karola Strunk et al.
Laurin Beckmann et al.
With the goal to develop coralyne-based ligands for abasic site-containing DNA (AP-DNA), different synthetic routes towards the functionalization of coralyne were tested. In particular, the alkylation of the benzylic position in papaverine ...
Amino acid-based surfactants: sustainable synthesis and antimicrobial mechanisms [0.03%]
基于氨基酸的表面活性剂：可持续合成及抗菌机制
Rafaela Gomes Bezerra,Lourdes Pérez,Francisco Fábio Oliveira de Sousa
Rafaela Gomes Bezerra
Antimicrobial therapy is becoming increasingly ineffective over infections due to the gradual microbial resistance to conventional treatments. This aspect highlights the urgent need for the development of new antimicrobial agents. In this c...
Retraction: α,ß-Didehydrosuberoylanilide hydroxamic acid (DDSAHA) as precursor and possible analogue of the anticancer drug SAHA [0.03%]
撤稿：α,ß-二去氢豆鳞茎酸酰胺草酸盐（DDSAHA）作为抗癌药物SAHA的前体和可能的类似物
Shital K Chattopadhyay,Subhankar Ghosh,Sarita Sarkar et al.
Shital K Chattopadhyay et al.
[This retracts the article DOI: 10.3762/bjoc.15.245.]. Keywords: HDAC inhibition; anticancer drug; cross met...
Synthesis and acaricidal activity against Varroa destructor of α- and γ-costic acid dimers [0.03%]
α-和γ-_costic酸二聚体的合成及对Varroa destructor的杀螨活性研究
Alessandro Santarsiere,Ernesto Santoro,Maria Letizia Ciavatta et al.
Alessandro Santarsiere et al.
α-Costic acid is a natural sesquiterpene possessing diverse biological activities. Among these, the most promising property for practical application is its acaricidal activity against Varroa destructor, considered the most important and d...
Controlled supramolecular assemblies of luminescent tridentate cyclometalated alkynylgold(III) amphiphiles in aqueous media [0.03%]
水相中发光三齿式金(III)两亲性鳌合物的超分子自组装体的控制合成
Kelvin Sze-Yim Cai,Brian Boyan Liu,Franco King-Chi Leung
Kelvin Sze-Yim Cai
Gold(III) complexes and amphiphiles have been extensively investigated over a decade. Supramolecular assemblies of gold(III) amphiphiles in aqueous media exhibit high sensitivities to external stimulations for soft functional materials. Her...
One-pot four-component sequential synthesis of S-alkyl dithiocarbamates using lipase as a biocatalyst [0.03%]
使用脂肪酶作生物催化剂的一锅法合成S-烷基二硫代氨基甲酸酯类化合物
Mansour Shahedi,Pargol Tahmasebi Pour,Zohreh Habibi
Mansour Shahedi
Dithiocarbamates are widely recognized for their versatile applications in both agriculture as effective pesticides and medicine, where they serve as antifungal and anticancer agents. As a result, their synthesis has garnered significant at...
Synthesis of novel 1,2,4-oxadiazole-isoxazoline hybrids and their in silico potential with adenosine receptors [0.03%]
新型1,2,4-噁二唑异噁唑啉杂化物的合成及其与腺苷受体的理论研究
Pshtiwan S Mohammed,Mohammed K S Dalo,Onur C Yazıcı et al.
Pshtiwan S Mohammed et al.
A concise and efficient synthetic route to novel 1,2,4-oxadiazole-isoxazoline hybrids 7 has been developed via regioselective 1,3-dipolar cycloaddition of in situ-generated nitrile oxides with 3-(p-substituted-aryl)-5-vinyl-1,2,4-oxadiazole...
Semisynthesis, characterisation, and antibacterial evaluation of a novel lecanoric acid-derived amide library [0.03%]
一种新型地钱酸衍生物酰胺类库的半合成、表征及抗菌评价
Ethan D Abbott,Sasha Hayes,Jonathan M White et al.
Ethan D Abbott et al.
The known lichen depside, lecanoric acid (1), was identified as a scaffold of interest for the generation of a unique semisynthetic biodiscovery screening library. Large-scale extraction and isolation on the Australian-sourced lichen Parmot...
Synthesis and optical resolution of 4,5-diaminohomoadamantane: a promising scaffold for chiral ligands and bioactive compounds [0.03%]
4,5-二氨基齐敦茋的合成与光学拆分：一种很有前途的手性配体和生物活性化合物结构单元
Polina Anatolyevna Man&#x;kova,Vadim Andreevich Shiryaev,Olga S Podlipnova et al.
Polina Anatolyevna Man&#x;kova et al.
Vicinal diamines based on a rigid polycyclic framework such as homoadamantane remain underexplored. We anticipated that the unique steric and lipophilic properties of chiral trans-4,5-diaminohomoadamantane could provide the necessary stereo...
Rh(III)-catalyzed chelation-assisted C-H activation/annulation of 2-arylimidazolines with cyclic diazo-1,3-dicarbonyl compounds: a novel approach to tetracyclic annulated derivatives of 2,3-dihydroimidazo[2,1- a]isoquinoline [0.03%]
Rh(III)催化环状二氮杂羰基化合物与2-芳基咪唑啉的螯合辅助C-H活化/环加成反应：合成四环化2,3-二氢苯并[b]噻喃并[3,2-b]吡咯的新方法
Ivan Lyutin,Grigory Kantin,Olga Bakulina et al.
Ivan Lyutin et al.
2-Arylimidazolines were annulated with cyclic diazo-1,3-dicarbonyl compounds under Rh(III)-catalysis for the first time. The developed general and efficient approach based on CH-activation allowed the efficient preparation of five novel typ...