Enhanced Fluorescence of Near-Infrared Anti-CEA Antibodies for Visualizing Colorectal Cancers Using Modified Heptamethine Cyanines [0.03%]
用于结直肠癌可视化近红外抗CEA抗体增强荧光的七甲川菁衍生物修饰
K Cox,J Jitender,S Mehta et al.
K Cox et al.
Background: The clinical success of fluorescence-guided surgery is dependent on tumor-specific probes that can achieve high tumor-to-background contrast. Conventional near-infrared (NIR) fluorophores often alter the pharm...
Jia Xu,Wei Sun,Xin Zhang et al.
Jia Xu et al.
Molecular imaging exhibits remarkable potential in immune cell tracking and advancing personalized clinical management, providing not only diagnostic and prognostic information but also enabling treatment efficacy quantification and therape...
A Bioimaging Study of 89Zr-Bintrafusp Alfa PET Scans in Patients with Advanced or Metastatic NSCLC Receiving Bintrafusp Alfa Alone or in Combination with Chemotherapy [0.03%]
一项生物影像研究：评估Bintrafusp alfa或联合化疗治疗晚期或转移性NSCLC患者的89Zr-Bintrafusp alfa PET扫描结果
Hui K Gan,Sagun Parakh,Sze Ting Lee et al.
Hui K Gan et al.
Rationale: Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the human transforming growth factor β receptor II (TGF-βRII or TGF-β "trap") and human immunoglobulin ...
Preliminary Results on the Added Value of Parametric Images Derived from 18F-fluoroethyl-L-tryptophan PET for Posttreatment Glioblastoma Assessment [0.03%]
18F-氟乙基-L-色氨酸正电子发射断层显像图对胶质母细胞瘤治疗后评估的附加价值的初步研究结果
Csaba Juhász,Geoffrey R Barger,Michael Dominello et al.
Csaba Juhász et al.
Background: Increased amino acid transport in gliomas allows imaging of metabolically active tumor volume by PET. Tryptophan analog PET radiotracers can provide additional information by tracking tumoral metabolism via th...
124I-Labeled Specific Antibody Targeting LAG-3 for ImmunoPET [0.03%]
针对LAG-3的放射性124I抗体用于免疫正电子发射断层扫描（ImmunoPET）
Lixin Ding,Feng Wang,Yongxiang Pan et al.
Lixin Ding et al.
Purpose: Lymphocyte-activation gene 3 (LAG-3), a next-generation immune checkpoint, has emerged as a promising therapeutic target, but noninvasive tools for evaluating LAG-3 expression remain limited. Herein, we explored ...
AMPK Activation by MK-8722 Measured with [18F]FDG-PET Imaging in Rodents and Non-Human Primates [0.03%]
新型AMPK激活剂MK-8722的体内评价及其与18F-FDG摄取的关系研究
Daniel J Rubins,Xiangjun Meng,Shubing Wang et al.
Daniel J Rubins et al.
Introduction: The adenosine monophosphate-activated protein kinase (AMPK) induces glucose uptake by increasing the expression of glucose transporter 4 (GLUT4), and [18F]Fluorodeoxyglucose (FDG) is readily transported into...
Identification of a Novel TIM-3 Targeting Peptides Probe to Indicate the Immunomodulation of SBRT Combined with Anti-TIM-3 Therapy in HCC [0.03%]
识别新型TIM-3靶向肽探针以指示立体定向体放射治疗联合抗TIM-3免疫治疗肝癌的免疫调节作用
Muhao Xu,Cheng Wang,Peng Zeng et al.
Muhao Xu et al.
Purpose: Given the escalating global burden and high mortality associated with hepatocellular carcinoma (HCC), immune checkpoint inhibitors (ICIs) have emerged as a critical therapeutic approach. T cell immunoglobulin and...
Evaluation of Pafolacianine (Cytalux®) for Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma: A Negative Study with Important Clinical Implications [0.03%]
帕法拉青啶（CYTALUX）在头颈部鳞状细胞癌荧光引导手术中应用的评估：一项阴性研究及其重要的临床意义
Lucas Mani,Syeda Maria Ahmad Zaidi,Estelle Martin et al.
Lucas Mani et al.
Background: Pafolacianine (Cytalux®) represents the first FDA-approved tumor-specific fluorescence imaging agent, demonstrating efficacy in ovarian cancer through folate receptor-α (FR-α) targeting. Given the need for ...
Ethyl Pyruvate Promotes Wound Healing in Elastase-Induced Lung Injury in Mice as Assessed by Hyperpolarized 129Xe Magnetic Resonance Imaging [0.03%]
乙基丙酮酸促进弹性蛋白酶诱导的小鼠肺损伤的伤口愈合（基于超极化129Xe磁共振成像评估）
Atsuomi Kimura,Akihiro Shimokawa,Neil J Stewart et al.
Atsuomi Kimura et al.
Purpose: Wound healing process in lung injury involves the activation of the mitogen-activated protein kinase (MAPK) pathway. In this study, we investigated the role of the MAPK pathway in wound healing in a murine model ...
PET Imaging of CD38 and IND enabling studies of [89Zr]Zr-DFO-Isatuximab [0.03%]
基于[89Zr]Zr-DFO-Isatuximab的CD38 PET显像及其IND申报前研究
Brian D Wright,Hailey A Houson,Solana Fernandez et al.
Brian D Wright et al.
Background: CD38 is an excellent biomarker and therapeutic target for multiple myeloma due to its high expression on cancerous cells in comparison to healthy cells. ...