In vivo Fluorescent Molecular Imaging Using Nanobodies Labeled with Next-Generation FNIR-Tag-Dyes [0.03%]
新一代FNIR-Tag-染料标记的纳米抗体介导的活体分子荧光成像
Dora M Chigoho,Marcus C M Stroet,Jelena Saliën et al.
Dora M Chigoho et al.
Purpose: Fluorescently labeled Nanobodies (Nbs) provide rapid, specific, and high-contrast molecular imaging capabilities, making them well-suited for applications such as fluorescence-guided surgery. As dye properties ca...
Pharmacokinetic Modeling of Hepatospecific MRI Contrast Agent Flux in Large Animal Models by Dynamic Contrast-Enhanced MRI [0.03%]
基于动态对比增强MRI的肝特异性MRI对比剂在大型动物模型中转运的药代动力学建模研究
Matthew T Latourette,Jeremy M L Hix,Jie Huang et al.
Matthew T Latourette et al.
Purpose: Evaluate the feasibility of using dogs and a pig as translational models for assessing hepatic flux of hepatospecific gadolinium-based contrast agents using dynamic contrast-enhanced MRI (DCE-MRI). ...
Correction: Sonodynamic Therapy-Enhanced Immunotherapy for Triple-Negative Breast Cancer: Mechanistic Advances, Nanoplatform Strategies, and Clinical Prospects [0.03%]
关于声动力学增强免疫治疗三阴性乳腺癌的更正：机制进展，纳米平台策略和临床前景
Ramanjireddy Tatiparthi,Ansuman Panda,Mvnl Chaitanya et al.
Ramanjireddy Tatiparthi et al.
Published Erratum
Molecular imaging and biology. 2026 Jul 15. DOI:10.1007/s11307-026-02123-7 2026
FcRn-Targeted Alpha Therapy Using [225Ac]Ac-Macropa-Rozanolixizumab Enables Potent Antitumor Activity [0.03%]
靶向于FcRn的放射性免疫治疗新方法[225Ac]Ac-Macropa-Rozanolixizumab可有效抑制肿瘤生长
Saba Shirin,Syed Qaiser Shah,Ralph Santos-Oliveira
Saba Shirin
Purpose: Overexpression of FcRn in multiple hematologic and solid cancers makes it a promising target for monoclonal antibodies, though its presence in healthy tissue calls for proper assessment of toxicity. Here, we repo...
Collagen-binding ⁶⁸Ga-CBP8 PET/MR in Deep Pelvic Endometriosis: First-in-human Application [0.03%]
人用胶原结合的68镓-CBP8 PET/MR检查深部盆腔内异症首次应用研究
Antonino Andrea Blandino,Peter Caravan,Anuradha S Shenoy-Bhangle et al.
Antonino Andrea Blandino et al.
Purpose: To evaluate the feasibility of collagen-binding ⁶⁸Ga-CBP8 PET/MR for the noninvasive detection of deep infiltrating endometriosis. Material and...
Limited Contribution of T1 Relaxation to GluCEST MRI Signal Differences Across Four Rat Models with Distinct Pathophysiological Features [0.03%]
四种病理生理特征不同的大鼠模型中T1弛豫对GluCEST MRI信号差异的贡献有限
Donghoon Lee,Hind Binjaffar,Yeon Ji Chae et al.
Donghoon Lee et al.
Purpose: To determine whether measured longitudinal relaxation time (T1) differences explain glutamate-weighted CEST (GluCEST) group differences across four rat disease models associated with glutamatergic alterations. ...
Automated cGMP Radiosynthesis of [18F]NOTA-ABY-030 with Aluminum Fluoride on the GE FASTlab Automated Synthesis Platform [0.03%]
基于铝氟化反应的GE FASTLAB模块化全自动合成[18F]NOTA-ABY-030系统及非临床研究
William Behof,Imtiaz Khan,Julian Grigg et al.
William Behof et al.
Background: Epidermal Growth Factor Receptor (EGFR) overexpression in Head and Neck Squamous Cell Carcinoma (HNSCC) is well documented and strongly correlated with aggressive phenotypes. As such EGFR is an excellent choic...
Cross-Species Quantitative Benchmarking of SSTR2 Radioligands in Fresh-Frozen Brain Sections: An Adaptable Framework for Radiopharmaceutical Development [0.03%]
新鲜冷冻脑切片中SSTR2放射配体的跨物种定量基准测试：放射药物开发的可扩展框架
Caitlin McCutcheon,Zachary Lawrence,Marie James et al.
Caitlin McCutcheon et al.
Rationale: Somatostatin receptor subtype 2 (SSTR2) is a G-protein coupled receptor overexpressed in multiple cancers, including neuroendocrine tumors, small cell lung cancer, and hepatocellular carcinoma. Clinical validat...
LLM-Enhanced Multimodal Fusion of SPECT Radiomics and Clinical Data for Predicting 131I Therapeutic Response in Differentiated Thyroid Cancer [0.03%]
基于LLM的SPECT影像组学和临床数据融合预测分化型甲状腺癌¹³¹I治疗反应的研究
Hangyu Wang,Erhao Chen,Liqin Pan et al.
Hangyu Wang et al.
Background: Patients with differentiated thyroid cancer (DTC) treated with radioactive iodine (RAI) remain at risk of adverse outcomes. Early prediction of RAI efficacy is critical for optimizing clinical management. ...
Direct Androgen Receptor Antagonism Enhances Therapeutic PSMA Radioligand Uptake in Prostate Cancer Models [0.03%]
直接雄激素受体拮抗增强前列腺癌模型中的PSMA放射配体摄取
Philipp E Hartrampf,Sebastian E Serfling,Natalie Hasenauer et al.
Philipp E Hartrampf et al.
Background: Prostate-specific membrane antigen (PSMA) is a central target for prostate cancer theranostics. Androgen receptor (AR) signaling has been implicated in regulating PSMA expression; however, whether different mo...