19F MR Imaging of Dule Lung Cancer Models with Two Administration Methods of PFC Nanoparticles [0.03%]
两种全氟碳纳米颗粒注射方式的 Duchesne 肺癌模型小鼠 19F MRI 对比研究
Fang Liu,Mengping Shao,Xiuan Xu
Fang Liu
Background: Pulmonary delivery of agents to lung is an effective method for the diagnosis and therapy of lung cancer. Purpose: To demon...
Positive Protective Effects of Sigma-1 Receptor Stimulation with Fluvoxamine after Myocardial Ischemia and Reperfusion in Rats [0.03%]
富氯西汀激活σ-1受体对心肌缺血再灌注损伤的保护作用及机制研究
Xue Zhang,Hiroshi Wakabayashi,Hiroshi Mori et al.
Xue Zhang et al.
Background: The sigma-1 receptor (Sig-1R) plays diverse roles in regulating Endoplasmic Reticulum (ER) stress, calcium handling, and ion channel activity under pathological conditions, offering cardioprotective effects in...
MIB guides: [89Zr]Zr-DFO-trastuzumab and [64Cu]Cu-NOTA-Trastuzumab for Preclinical Cancer Imaging [0.03%]
放射性药物[89Zr]Zr-DFO-曲妥珠单抗和[64Cu] Cu-NOTA-曲妥珠单抗用于癌症分子成像的药代动力学指导手册
Cristina Simó,Alexander C Vanover,E Carmen Azevedo et al.
Cristina Simó et al.
Radiopharmaceuticals based on antibody biomolecules are widely used in oncology for positron emission tomography (PET). Trastuzumab, an antibody that targets the epidermal growth factor receptor 2 (HER2), has been extensively studied for bo...
Diagnostic Value of [18F]-FDG and [68 Ga]-FAPI-04 PET/MRI for Lymph Node Metastasis in Papillary Thyroid Cancer [0.03%]
[18F]-FDG和[68Ga]-FAPI-04 PET/MRI在诊断乳头状甲状腺癌淋巴结转移中的价值
Tingting Han,Zhiyong Quan,Hongliang Wei et al.
Tingting Han et al.
Purpose: This study aimed to evaluate the diagnostic value of [18F]-FDG PET/MRI for the diagnosis of neck lymph node metastasis (LNM) in patients with initially diagnosed papillary thyroid cancer (PTC) and to compare it w...
Poor Diagnostic Performance of the Melanin-Binding Tracer [18 F]MEL050 in Human Melanoma Indicates Biological Heterogeneity [0.03%]
低诊断性能的黑色素结合示踪剂[18F] MEL050表明了生物异质性
Robert E Ware,Damien Kee,Peter Roselt et al.
Robert E Ware et al.
Purpose: Malignant melanoma is a highly lethal malignancy typically characterized by the expression of melanin, which is an attractive diagnostic and therapeutic target in these cancers because it is expressed in few othe...
Preclinical Evaluation of a Near-Infrared Labelled Antibody Targeting the Tumour Associated Xenoantigen N-Glycolyl-Neuraminic Acid GM3 Ganglioside [0.03%]
一种靶向肿瘤异种抗原N-岩藻糖基神经氨酸GM3神经节苷脂的近红外标记抗体的药物非临床评价
Kris Barreto,Wendy Bernhard,Darien Toledo et al.
Kris Barreto et al.
Purpose: Targeted and broadly applicable molecular targets are important for image guided surgery. Xenoantigens represent a particularly interesting class of targets. This study evaluates the xenoantigen N-glycolyl-neuram...
One-step Radiosynthesis and Preclinical Evaluation of Molecular Tracer [18F]FEtO-CHC Targeting Monocarboxylate Transporters for PET Imaging in Tumor-bearing Mice [0.03%]
一次性放射合成及[18F]FEtO-CHC小分子示踪剂的药代动力学评价及其在肿瘤鼠体内PET显像研究
Dongmei Shi,Ling Liu,Di Zhang et al.
Dongmei Shi et al.
Purpose: Monocarboxylate transporters (MCTs) play a pivotal role in tumor metabolic symbiosis, acid resistance, and metastatic progression. Herein, we report the development of [18F]FEtO-CHC, a novel MCTs-targeted positro...
Long-term Local Control Following CEA-targeted Fluorescence-guided Surgery in Patients With Locally Advanced and Recurrent Rectal Cancer [0.03%]
局灶 advanced 和复发性直肠癌患者远端局部控制的长期结局：一项前瞻性单臂 2 期试验
Mats I Warmerdam,Davy M J Creemers,Miranda Kusters et al.
Mats I Warmerdam et al.
Purpose: In our previous phase 2 trial, patients with locally advanced (LARC) or locally recurrent rectal cancer (LRRC) received SGM-101, a CEA-targeted fluorescent agent, to enable real-time near-infrared fluorescence (N...
Evaluation of 177Lu-Labeled Lipiodol as a Targeted Radionuclide Therapy for Hepatocellular Carcinoma in a Preclinical Xenograft Model [0.03%]
177Lu标记Lipiodol治疗肝癌细胞肿瘤异种移植模型的疗效评估研究
Yumiko Kono,Keita Utsunomiya,Takahiro Shiraishi et al.
Yumiko Kono et al.
Background: Lutetium-177 (177Lu) is a promising radionuclide for targeted cancer therapy due to its favorable theranostic properties. Transarterial lipiodol embolization is widely used for hepatocellular carcinoma (HCC), ...
Go Fish! Hepatic Uptake of Clinical Hepatospecific Gadolinium-Based MRI Contrast Agents in Zebrafish is Similar to Humans [0.03%]
利用斑马鱼肝脏特异性超顺磁性氧化铁类MRI造影剂的肝摄取研究其药代动力学特征与临床疗效的关系
Josie A Shapiro,Tapas Bhattacharyya,Lauren A Squire et al.
Josie A Shapiro et al.
Purpose: Zebrafish are a useful organism for investigating liver disease due to their genetic similarities with humans, particularly in genes associated with liver function. It has been posited that liver function can be ...