Photoacoustic Imaging of Muscle Tissue Oxygenation as a Noninvasive Biomarker in Mouse Models of Sickle Cell Disease [0.03%]
用于镰状细胞病小鼠模型肌肉组织氧合的光声成像作为无创生物标志物
Jeffrey Morin,Megan Brophy,John Stansfield et al.
Jeffrey Morin et al.
Purpose: To develop and validate photoacoustic imaging (PAI) as a method to assess hemoglobin counts and muscle tissue oxygen saturation in a mouse model of Sickle Cell Disease (SCD. ...
Malignant Pleural Mesothelioma (MPM) Evaluation with [11C]-Methionine PET/CT Before and After Talc Pleurodesis [0.03%]
pleural积气的恶性间皮瘤(MPM)患者在胸膜固定术前后的甲硫氨酸正电子发射断层扫描/ X线计算机体层摄影检查(PET/CT)评估
Egesta Lopci,Angelo Castello,Alberto Testori et al.
Egesta Lopci et al.
Background: Malignant pleural mesothelioma (MPM) poses an imaging challenge that requires special attention, especially in patients who have undergone talc pleurodesis. [18F]FDG PET/CT (FDG PET) is a validated imaging mod...
Design of a Bifunctional pHLIP-RGD Scaffold for Site-Specific [99mTc] Tc Labeling: Radiochemical Evaluation and Proof-of-Concept Tumor Targeting [0.03%]
一种 bifunctional pHLP-RGD 框架的合成用于[99mTC] TC 的特定位点标记：放射化学评估及概念验证肿瘤靶向作用研究
Mingming Yu,Yuehua Chen,Bangxu Yu et al.
Mingming Yu et al.
Purpose: To develop a novel molecular scaffold designed for dual targeting via site-specific [99mTc] Tc labeling, we report its radiochemical evaluation and preliminary targeting efficacy in acidic tumor models. ...
Sonodynamic Therapy-Enhanced Immunotherapy for Triple-Negative Breast Cancer: Mechanistic Advances, Nanoplatform Strategies, and Clinical Prospects [0.03%]
声动力学增强免疫治疗三阴性乳腺癌：机制、纳米平台策略及临床应用前景
Ramanjireddy Tatiparthi,Ansuman Panda,Mvnl Chaitanya et al.
Ramanjireddy Tatiparthi et al.
Triple-negative breast cancer (TNBC) remains a major clinical challenge owing to its inherent resistance to treatment, immune-competent tumor microenvironment, and early metastasis. Sonodynamic therapy (SDT), which generates reactive oxygen...
Engineering Anti-MMP-9 Peptide-Modified Nanoparticles for Precision MRI Diagnosis of Endometriosis [0.03%]
工程化抗MMP-9肽修饰的纳米颗粒用于精准磁共振诊断子宫内膜异位症
Qi Zhang,Haicheng Li,Linghui Xu et al.
Qi Zhang et al.
Endometriosis diagnosis is often limited by the resolution of conventional imaging techniques (ultrasound/non-targeted MRI) as well as the invasiveness and recurrence risks associated with laparoscopy. To overcome these challenges, we devel...
Value of Multitracer Imaging in Hepatocellular Carcinomas with Different Metastatic Potential [0.03%]
不同转移潜能的肝细胞癌的多示踪剂分子影像价值研究
Tingting He,Cong Zhang,Jinming Zhang et al.
Tingting He et al.
Background: Hepatocellular carcinoma (HCC) shows marked heterogeneity and varying metastatic potential, challenging prognosis and treatment. This study evaluated multitracer PET imaging with [18F]FDG, [18F]FLT, and [18F]A...
Imaging vascular characteristics and glycolytic metabolism of glioblastoma in a chick embryo model using 1H MRI and [18F]FDG-PET [0.03%]
基于小鸡胚胎模型的胶质母细胞瘤血管特征及糖酵解代谢的1H-MRI和[18F]FDG-PET成像研究
Elisabeth Non Gash,Jan Schulze,Sarah E Barnett et al.
Elisabeth Non Gash et al.
Purpose: To assess hypoxia-associated host-tumour vascular adaptations and glycolytic metabolism in the chick chorioallantoic membrane (CAM) glioblastoma model. ...
Template-Directed RIG-I Agonist Assembly for Image-guided Targeted Cancer Immunotherapy [0.03%]
基于模板的RIG-I激动剂组装用于图像引导的靶向癌症免疫治疗
Subrata K Ghosh,Douglas Lazarus,Neil Robertson et al.
Subrata K Ghosh et al.
Purpose: Tumor-specific immunotherapies selectively target tumor cells with reduced toxicity compared to conventional treatments. Pattern recognition receptors, such as retinoic acid-inducible gene I (RIG-I)-like receptor...
Theranostic and Radionuclide-based Treatment Approaches for Radioiodine-refractory Thyroid Cancer: From Biology to Clinical Application [0.03%]
用于碘难治性甲状腺癌的诊疗一体化及核素治疗策略研究：从基础到临床
Mubeen Hussein Arawker,Fitrat Habibullah,Lijun Fu et al.
Mubeen Hussein Arawker et al.
When differentiated thyroid cancer stops taking up radioiodine, treatment becomes significantly more challenging, and the disease often behaves more aggressively. Systemic therapies such as multikinase inhibitors and mutation-specific drugs...
Exploration of the Feasibility of One-Day Dual-Low-Activity 68Ga-DOTATATE and 18F-FDG PET/MR in Patients with Neuroendocrine Neoplasms [0.03%]
神经内分泌肿瘤患者一日双低剂量68Ga-DOTATATE和18F-FDG PET/MR检查的可行性研究
Wenjin Zhao,Lifang Pang,Yunze Xie et al.
Wenjin Zhao et al.
Purpose: The standard 2-day dual-tracer PET protocol provides more information but is time consuming. Thus, this study aimed to validate the feasibility of 1-day 68Ga-DOTATATE and 18F-FDG dual-low-activity PET/MR imaging ...