Fibrotic Disease: from Signaling Pathways and Biomarkers to Molecular Imaging [0.03%]
纤维化疾病：从信号通路和生物标志物到分子影像学
Mobin Ghazaiean,Patrick J Riss,Alireza Mardanshahi et al.
Mobin Ghazaiean et al.
Fibrotic diseases are characterized by excessive accumulation of extracellular matrix (ECM) components following tissue injury, ultimately leading to organ dysfunction and failure. The progression of fibrosis is governed by complex molecula...
CREBBP Mutation as a Culprit for Negative SSTR2 PET in Neuroendocrine Tumors [0.03%]
CREBBP基因突变是神经内分泌肿瘤中生长抑素受体SSTR2阴性的罪魁祸首
Arvin Haj-Mirzaian,Shadi A Esfahani,Umar Mahmood et al.
Arvin Haj-Mirzaian et al.
Purpose: This study aimed to elucidate the molecular and genetic factors contributing to negative 68Ga-DOTATATE PET imaging in neuroendocrine tumors (NETs). By integrating whole exome sequencing (WES) and single-cell RNA ...
Enhancing the Half-Life of ODAP-Urea Based Radioligands by Incorporating Albumin-Binding Moieties [0.03%]
通过引入白蛋白结合配体延长ODAP-尿素基放射性配体的半衰期
Xiang-Yi Chen,Yan Zhang,Xiaojiang Duan et al.
Xiang-Yi Chen et al.
Purpose: Prostate-specific membrane antigen-targeted radioligand therapy (PSMA-RLT) is a promising approach to treating metastatic castration-resistant prostate cancer (mCRPC). With the emergence of oxalyldiaminopropionic...
Reengineered Anti-CD4 Cys-diabody Variants for 89Zr-immunoPET of CD4+ T Cells in Immunocompetent Mice [0.03%]
用于免疫小鼠中T细胞的89Zr-免疫PET的重新设计的抗CD4半胱氨酸二抗体变异体
Felix B Salazar,Richard Tavaré,Arya Ökten et al.
Felix B Salazar et al.
Purpose: CD4+ T cells (T helper and T reg) play an important role in the immune system and are influential in autoimmune diseases (e.g., rheumatoid arthritis, inflammatory bowel disease) and cancer (antitumor immunity). N...
In vivo Multimodal Magnetic Particle Imaging for Early Detection of Ischemic Stroke in Tree Shrews [0.03%]
用于无尾猴缺血性卒中早期检测的多模态磁颗粒成像活体研究
Bo Zhang,Tao Zhu,Haoran Zhang et al.
Bo Zhang et al.
Purpose: Ischemic stroke is a significant threat to human life and health, and timely diagnosis is essential for improving patient outcomes. Magnetic Particle Imaging (MPI), as an emerging high-sensitivity imaging technol...
PET Study of S1PR1 Expression in Rodent Model of Myocardial Infarction [0.03%]
小鼠心肌梗死后S1PR1表达的正电子发射断层扫描研究
Hong Chen,Lin Qiu,Hao Jiang et al.
Hong Chen et al.
Purpose: Acute myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide. Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator influencing numerous physiological processes. S1PR1 is the pre...
Development and Evaluation of a Vinyl Sulfone-Based Fluorine-18 Labeling Method for Constructing PSMA-targeted Prostate Cancer Imaging Agents [0.03%]
一种用于构建靶向前列腺癌成像剂的 vinyl sulfone 基氟标记法的发展与评估
Changjiang Wang,Ruiling Long,Mei Hu et al.
Changjiang Wang et al.
Purpose: Since prostate-specific membrane antigen (PSMA) is widely expressed in nearly all stages of prostate cancer (PCa), PSMA tracers can be considered a viable diagnostic tool for PCa. Compared to 68Ga-labeled PSMA ag...
Preclinical Evaluation of Novel SGLT2-Targeted Near-Infrared Optical Imaging Agent for Early-Stage Pulmonary Adenocarcinoma [0.03%]
新型SGLT2靶向近红外光学成像剂在肺腺癌早期诊断中的临床前评估研究
Katherine Ortmeyer Welch,Kelly Anne McGovern,Lydia Chen et al.
Katherine Ortmeyer Welch et al.
Purpose: Lung cancer is increasingly diagnosed at early stages, but intraoperative localization of early lesions remains challenging. Intraoperative molecular imaging (IMI) aids in localization of tumors during surgery; h...
Local Infusing Antiplatelet Microspheres to Prevent Thrombosis Post-PCI: a Feasibility Study in Rabbit Aorta [0.03%]
局部灌注抗血小板微球预防兔主动脉支架植入后再狭窄的可行性研究
Yueyou Peng,Kunkun Liu,Wei Tian et al.
Yueyou Peng et al.
Purpose: After percutaneous coronary intervention (PCI), dual antiplatelet therapy (DAPT) is required to prevent thrombosis, but systemic DAPT may increase bleeding risk. This study aimed to develop a new concept of antip...
Combining Dopamine Transporter and Amyloid PET Tracer: A Preclinical Study on Dual-Target Imaging [0.03%]
多巴胺转运蛋白和淀粉样pet示踪剂联合使用：双靶向显像的临床前研究
Bok-Nam Park,Su-Min Kim,Young-Sil An
Bok-Nam Park
Purpose: This study aimed to evaluate the feasibility and diagnostic utility of a dual-target positron emission tomography (PET) imaging approach using a cocktail of N-3-[18F]fluoropropyl-2β-carbomethoxy-3β-(4-iodopheny...