Preclinical Evaluation of an Anti-EphA2 Minibody-Based ImmunoPET Agent as a Diagnostic Tool For Cancer [0.03%]
基于抗EphA2迷你抗体的免疫正电子发射断层显像剂的临床前评估作为癌症诊断工具的效果
Peggy A Birikorang,H E G Wedaarachchi,Jordan A Smith et al.
Peggy A Birikorang et al.
Purpose: In this study, we report the development and characterization of a copper-64 (64Cu) radiolabeled anti-EphA2 minibody (Mb) for pre-treatment characterization of antigen expression via Positron Emission Tomography ...
Today's Research, Tomorrow's Practice - White Paper from the Translation of New Therapy (TNT) Radiotheranostics Kick-off Pre-meeting of the Annual World Molecular Imaging Conference 2024 [0.03%]
今日研究，明日实践——世界分子影像大会2024年新型疗法（TNT）核素诊疗一体化白皮书启动预备会议报告
Simone Krebs,Lisa Baird,Giacomo Pirovano et al.
Simone Krebs et al.
Theranostics, a concept combining "therapy" and "diagnostics", is poised to enter an exponential growth phase. By using specific diagnostic markers to guide the selection and application of targeted treatments directed at those markers, thi...
Development of New NanoAlbumin-based Radiotracers: Preclinical Evaluation Of [68Ga]Ga-DOTA-nanoHSA Conjugates for Lymphatic Imaging Applications [0.03%]
新型纳米白蛋白放射示踪剂的发展：[68Ga]Ga-DOTA-纳米HSA缀合物的淋巴系统成像应用的临床前评估
Vijayaraj Kuniyil Kulangara,Aida Mary Abreu Diaz,Sara M Elkashef et al.
Vijayaraj Kuniyil Kulangara et al.
Purpose: Sentinel lymph node (SLN) mapping is a critical procedure in the staging and treatment of cancers, such as breast cancer and melanoma. Current radiocolloids used in SLN localization, like [99mTc]Tc-Sulfur Colloid...
Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans [0.03%]
年龄和BMI对健康人体组胺H3受体占有率的影响研究
Yanghong Yang,Waleed Ibrahim,Paul Gravel et al.
Yanghong Yang et al.
Purpose: To assess alterations in H3R availability with age and body mass index (BMI) in healthy humans using in vivo [11C]GSK189254 positron emission tomography (PET) imaging. ...
PSMA-1-DOTA Potentially for Effective Targeted Radioligand Therapy of Prostate Cancer [0.03%]
潜在用于有效靶向放疗前列腺癌的PSMA-1-DOTA
Xinning Wang,Olga Sergeeva,Maxim Sergeev et al.
Xinning Wang et al.
Purpose: While PSMA-targeted radioligand therapy (RLT) has shown remarkable efficacy for treating end-stage prostate cancer, the α-emitting RLT often results in severe salivary gland toxicity, limiting its use. Various s...
Tailoring Image Contrast for Cellular Magnetic Resonance Imaging using Gadolinium Chelates and Superparamagnetic Iron Oxide Particles [0.03%]
利用超顺磁性氧化铁颗粒和钆螯合物调整图像对比度的细胞磁共振成像技术
Young Beom Kim
Young Beom Kim
To investigate magnetic relaxation properties of the tailored contrast using paramagnetic gadolinium (Gd) chelates and superparamagnetic iron oxide particles (SPIOs) for cellular magnetic resonance imaging. The study included three differen...
Advances in the Molecular Imaging of Sarcoma: An Emphasis on Metabolic Imaging [0.03%]
肉瘤分子影像学进展：侧重代谢影像学
Sriya Jonnakuti,Rizwan Naseer,Sze Jia Ng et al.
Sriya Jonnakuti et al.
Purpose: Sarcomas, malignancies of mesenchymal origin, present significant diagnostic and therapeutic challenges due to their heterogeneity and low incidence. This review aims to examine the evolving role of fluorodeoxygl...
Enhanced Visualisation of Colorectal Tumours via Topical Application of EMI-137 in a Methylcellulose-Based Formulation: An ex vivo Feasibility Study [0.03%]
一种基于甲基纤维素的EMI-137制剂经 topical 应用于改善结直肠肿瘤可视化：一项体外可行性研究
Elham Zonoobi,Daan G J Linders,Stefan Harmsen et al.
Elham Zonoobi et al.
Background: Fluorescence-guided molecular imaging may improve colorectal cancer (CRC) patient outcomes by enabling early detection and better surgical treatment, relying on developing targeted fluorescent tracers to highl...
Evaluation of Indocyanine Green Derivatives with Sulfonic Acid and Carboxylic Acid Groups at the Benzoindolenine Moiety for Antibody-Based Tumor Imaging [0.03%]
评估苯并吲哚烯部分具有磺酸和羧酸基的吲哚菁绿衍生物用于基于抗体的肿瘤成像
Kohei Nakajima,Hirotaka Maeta,Hideo Takakura et al.
Kohei Nakajima et al.
Purpose: In target-specific cancer imaging, antibodies and their fragments are conjugated with fluorescent dyes to work as targeting molecules. We have recently developed indocyanine green (ICG) derivatives with anionic f...
PET Imaging of Diabetes-Induced Alterations in Metabolism and Immune Activation [0.03%]
糖尿病引起的代谢和免疫激活的正电子发射断层成像fragisticsfeld
Shannon E Lynch,Heba M Alsheikh,Patrick N Song et al.
Shannon E Lynch et al.
Introduction: Obesity and type 2 diabetes (T2D) influence the tumor microenvironment by altering glucose metabolism, which has been shown to decrease immune cell infiltration and activation. Positron emission tomography (...