PET Imaging of CD38 and IND enabling studies of [89Zr]Zr-DFO-Isatuximab [0.03%]
基于[89Zr]Zr-DFO-Isatuximab的CD38 PET显像及其IND申报前研究
Brian D Wright,Hailey A Houson,Solana Fernandez et al.
Brian D Wright et al.
Background: CD38 is an excellent biomarker and therapeutic target for multiple myeloma due to its high expression on cancerous cells in comparison to healthy cells. ...
Molecular Insights into BZW1 Expression and [18F]FDG PET/CT Metabolic Parameters in LUAD [0.03%]
LUSC和LUAD中BZW1表达及[18F]FDG PET/CT代谢参数的分子研究
Jiahe Li,Siqi Wang,Guangfang Chen et al.
Jiahe Li et al.
Purpose: Early detection and intervention in lung adenocarcinoma (LUAD) are critical for improving patient prognosis. This study explores the role of basic leucine zipper and W2 domains 1 (BZW1, BZAP45) in regulating mali...
Comparison of [68Ga]Ga-FAPI-04 PET/CT, [18F]FDG PET/CT, Enterography, and Intestinal Ultrasound in Assessing Crohn's Disease [0.03%]
比较[68Ga]Ga-FAPI-04 PET/CT、[18F]FDG PET/CT、肠镜和肠道超声在评估克罗恩病中的作用
Jieling Zheng,Hongxu Zhu,Linlin Zhang et al.
Jieling Zheng et al.
Purpose: We aimed to compare the diagnostic performance of [68Ga]Ga-FAPI-04 PET/CT, [18F]F-FDG PET/CT, enterography and intestinal ultrasound (IUS) in detecting inflamed segments in patients with Crohn's disease (CD), as ...
Molecular Imaging of Pancreatic Duct Adenocarcinoma Using [18F]JR-1004, a Cannabinoid Type 2 Receptor Targeted Positron Emission Tomography (PET) Probe [0.03%]
用于靶向成像胰腺导管腺癌中大麻素受体2的正电子发射断层显像(PET)探针[18F]JR-1004分子影像学研究
Can Jin,Xinghai Cao,Junwei Chen et al.
Can Jin et al.
Purpose: Pancreatic ductal adenocarcinoma (PDAC) represents a highly aggressive malignancy with a 5-year survival rate below 10% and poor prognosis. Early diagnosis of PDAC remains a significant challenge due to its nonsp...
Staging Prostate Cancer with AI: A Comparative Study of Large Language Models and Expert Interpretation on PSMA PET-CT Reports [0.03%]
基于AI的前列腺癌分期：大型语言模型与专家对PSMA PET-CT报告解读的比较研究
Rashad Ismayilov,Ayse Aktas,Esra Arzu Gencoglu et al.
Rashad Ismayilov et al.
Purpose: Accurate staging of prostate cancer is essential for therapeutic decision-making. While PSMA PET-CT reports offer rich clinical data, their unstructured format hinders large-scale analysis. Recent advances in lar...
Sarcopenia in Aging: Pathogenesis, Diagnosis, and Emerging Therapeutic Frontiers [0.03%]
衰老相关的肌少症：病因、诊断及新兴的治疗前景
Madhan Jeyaraman,Naveen Jeyaraman,Arulkumar Nallakumarasamy et al.
Madhan Jeyaraman et al.
Sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, remains a formidable challenge in aging populations. This review synthesizes current knowledge on its multifactorial pathogenesis, including mitochondri...
A Claudin-1 Near-Infrared Fluorescent Antibody Conjugate for In Vivo Primary and Metastatic Colorectal Cancer Detection [0.03%]
一种针对Claudin-1的近红外荧光抗体偶联物用于体内原发性和转移性结直肠癌检测
Mark Primeaux,Ritika Gupta,Iram Fatima et al.
Mark Primeaux et al.
Purpose: Despite advancements in colorectal cancer (CRC) therapy, surgery remains the only curative option. Incomplete resection resulting in tumor cell positive surgical margins occurs in ~ 7% of CRC surgeries and is ass...
First-in-Human Biodistribution and Dosimetry of [11C]Trimethoprim [0.03%]
[11C]_trimethoprim首次人体内的分布和剂量学研究
Anthony J Young,Robert K Doot,Joshua K Cho et al.
Anthony J Young et al.
Trimethoprim (TMP) is a reversible inhibitor of the prokaryotic enzyme dihydrofolate reductase (DHFR) used for the treatment or prophylaxis of bacterial infections. [11C]trimethoprim ([11C]TMP) is a positron emission tomography (PET) imagin...
In-Ovo Imaging with Ostrich Eggs: Eggshell Attenuation in CT and Limitations of Organ Dosimetry [0.03%]
鸵鸟蛋的壳内成像：CT中的蛋壳衰减及器官剂量学限制
Christian Kühnel,Tabea Nikola Schmidt,Olga Perkas et al.
Christian Kühnel et al.
Ostrich eggs have recently attracted interest as an alternative model in preclinical nuclear medicine imaging. The ability to be used in clinical PET/CT (positron emission tomography/computed tomography) systems and their ethical profile ar...
Nanophotonics in Molecular Imaging and Biomedicine: Diagnostics, Therapies, and Translational Challenges [0.03%]
纳米光子学在分子影像及生物医学中的应用：诊断、治疗及转化挑战
Youssef M Hassan,Ahmed Wanas,Ayat A Ali et al.
Youssef M Hassan et al.
Nanophotonics-the manipulation of light at the nanometer scale within biological systems-is transforming molecular imaging and photobiology, enabling advanced in vivo imaging, diagnostics, and therapy guidance. This review outlines core nan...