EWSR1-SMAD3-rearranged fibroblastic tumor: a case report with literature review [0.03%]
EWSR1-SMAD3重排的成纤维细胞肿瘤的病例报告及文献回顾
Guanghong Yang,Zhenwei Chen,Yuanli Zhong et al.
Guanghong Yang et al.
This paper discusses an EWSR1-SMAD3-rearranged fibroblastic tumor (ESFT) occurring in the wrist of a 5-year-old child and summarizes its clinicopathological features, immunohistochemical phenotype, and molecular characteristics to improve t...
The emerging role of neutrophil extracellular traps in liver diseases: a narrative review [0.03%]
中性粒细胞胞外陷阱在肝脏疾病中的作用：叙述性综述
Lanbao Ye,Yan Chen,Zefeng Liu et al.
Lanbao Ye et al.
Neutrophil extracellular traps (NETs) are web-like chromatin structures released by neutrophils that play dual roles in host defense and tissue injury. In liver diseases, NETs have emerged as key pathogenic mediators. This narrative review ...
Lymphatic system in the liver: a new frontier in liver physiology and oncology [0.03%]
肝脏的淋巴系统：肝生理和肿瘤学的新前沿
Reiichiro Kondo,Rio Sonoda,Jun Akiba
Reiichiro Kondo
The lymphatic system in the liver has long been regarded as a passive transport route responsible for interstitial fluid drainage. However, recent research has redefined it as a "new frontier in hepatology," playing active and multifaceted ...
Integration of L1CAM and β-catenin immunohistochemistry for prognostic risk stratification of endometrial carcinoma: a practical approach for resource-limited settings [0.03%]
L1细胞黏附分子联合β-catenin免疫组化在子宫内膜癌预后分层中的应用价值研究一项适合资源有限地区的实用方法学探索
Sara Eldegwi,Basma Gadelhak,Nadia Bassiouny et al.
Sara Eldegwi et al.
Accurate prognostic stratification of endometrial carcinoma (EC) remains challenging in resource-limited settings lacking molecular sequencing. We investigated whether immunohistochemical (IHC) assessment of combined L1CAM/β-catenin expres...
G protein-coupled receptor 56-mediated lung metastasis mechanisms in osteosarcoma LM8 cells [0.03%]
骨肉瘤LM8细胞肺转移的G蛋白偶联受体56介导机制研究
Nobuyoshi Suzuki,Erika Hayakawa,Hiroshi Nishiura et al.
Nobuyoshi Suzuki et al.
Osteosarcoma has a poor prognosis and frequently metastasizes to the lungs. This study examined the role of transglutaminase 2 (TGM2), a ligand for adhesion G protein-coupled receptor 56 (GPR56), in lung metastasis of LM8 mouse osteosarcoma...
Scavenger receptor class B type I (SR-BI) as a potential therapeutic target in multiple myeloma [0.03%]
清道夫受体B类Ⅰ型(SR-BI)作为潜在的治疗靶点在多发性骨髓瘤中的作用
Yoshihiko Kondo,Hiromu Yano,Yukio Fujiwara et al.
Yoshihiko Kondo et al.
Multiple myeloma (MM) is a malignant plasma cell neoplasm characterized by marked biological heterogeneity and complex metabolic reprogramming. Although dysregulated lipid metabolism has been implicated in MM, its morphological correlations...
Significance of p53-binding protein 1 as an in situ DNA damage marker for ulcerative colitis [0.03%]
p53结合蛋白1作为溃疡性结肠炎原位DNA损伤标志物的意义
Nazigul Zhumagazhiyeva,Miho Doo,Yerkezhan Sailaubekova et al.
Nazigul Zhumagazhiyeva et al.
Ulcerative colitis is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon. The extensive and persistent mucosal damage associated with ulcerative colitis (UC) can contribute to carcinogenesis, thereby ...
Effect of combination of osteoblasts and octacalcium phosphate collagen composite on bone regeneration in rat calvarial bone defect [0.03%]
成骨细胞与八钙磷酸钙-胶原复合物对颅盖骨缺损再生修复的影响
Hiroshi Kato,Satoki Nishimura,Shoko Onodera et al.
Hiroshi Kato et al.
This study aimed to assess the effect of a combination of osteoblasts and octacalcium phosphate collagen composite (OCP/Col) on bone regeneration. In oral and maxillofacial surgery, OCP/Col has been clinically used as artificial bone. Altho...
APC in the nervous system [0.03%]
神经系统的APC蛋白
Takao Senda,Nami O Yamada,Takanori Onouchi
Takao Senda
The APC (adenomatous polyposis coli) gene, which was first discovered as a colorectal cancer suppressor gene, is highly expressed in the nervous system. The Apc gene/Apc protein is deeply involved in brain development and morphogenesis. In ...
Effect of S1P/S1PR on bone metabolism in bisphosphonate-related osteonecrosis of the jaws [0.03%]
S1P/S1PR对双磷酸盐相关颌骨骨坏死骨代谢的影响
Ting Guo,Yuhao Wang,Dianri Wang et al.
Ting Guo et al.
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a major adverse effect of bisphosphonates, yet its underlying pathogenesis remains poorly understood. Bone metabolism and remodeling relies on the interaction between osteoblasts (...