Basil seed mucilage as a bioadhesive polymer: Development of naproxen sodium microspheres and suppositories with in-vitro and ex-vivo studies [0.03%]
番石榴籽粘液作为生物粘合聚合物的发展：含萘普生钠微球和栓剂的体外和组织试验研究
Devika Tripathi,Krislay Rathour,Prashant Pandey et al.
Devika Tripathi et al.
Background and purpose: The study explores basil seed mucilage as a bioadhesive carrier for naproxen sodium, demonstrating its ability to enhance solubility when administered rectally. The mucilage, derived from Ocimum ba...
Natural serine proteases and their applications in combating amyloid formation [0.03%]
天然丝氨酸蛋白酶及其在防治淀粉样纤维组装中的应用
Sanjay Kisan Metkar,Saranya Udayakumar,Agnishwar Girigoswami et al.
Sanjay Kisan Metkar et al.
Background and purpose: Amyloidosis is a group of diseases including diabetes type II and neurological disorders, such as Alzheimer's disease, Parkinson's disease, prion disease, etc., where a common trait is observed; ac...
Targeting hexokinase 2 to enhance anticancer efficacy of trichosanthin in HeLa and SCC25 cell models [0.03%]
靶向己糖激酶2以增强皂素在HeLa和SCC25细胞模型中的抗癌功效
Yan Zhou,Maoxin Ran,Wenying Shan et al.
Yan Zhou et al.
Background and purpose: Trichosanthin (TCS) is a plant-based ribosome-inactivating protein exhibiting a range of pharmacological properties, including abortifacient and anticancer. However, the routine clinical use in can...
Glyphosate-based herbicide metabolic profiles in human urine samples through proton nuclear magnetic resonance analysis [0.03%]
基于 proton 核磁共振分析的人尿样 Glyphosate 类除草剂代谢标志物动态分布研究
Preechaya Tajai,Giatgong Konguthaithip,Thanyaphisit Chaikhaeng et al.
Preechaya Tajai et al.
Background and purpose: Glyphosate-based herbicides, extensively utilized worldwide, raise concerns regarding potential human risks due to the detection of glyphosate (GLY) in human body fluids. This study aims to address...
Pharmacokinetics/pharmacodynamics of glucocorticoids: modeling the glucocorticoid receptor dynamics and dose/response of commonly prescribed glucocorticoids [0.03%]
糖皮质激素的药代动力学/药效学：类固醇激素受体动力学和常用皮质类固醇剂量反应关系模型化
David G Levitt
David G Levitt
Background and purpose: The main features of the dynamics of the glucocorticoid receptor (GR) have been known for 50 years: 1) in the absence of glucocorticoid (G), the receptor is localized entirely in the cytoplasm; 2) ...
Spray-dried cyclophosphamide-loaded polyhydroxyalkanoate microparticles: design and characterization [0.03%]
用于环磷酰胺加载的聚羟基脂肪酸乙酯微球的设计及性质表征
Sergei Lipaikin,Aleksei Dorokhin,Galina Ryltseva et al.
Sergei Lipaikin et al.
Background and purpose: Cyclophosphamide (CP) is a widely used antitumor and immunosuppressive drug, but it is highly cytotoxic and has carcinogenic and teratogenic potential. To reduce adverse effects of CP therapy and t...
Pharmacokinetics and metabolism of ketoconazole after single ocular instillation in Sprague-Dawley rats [0.03%]
一次单眼滴注酮康唑后的药代动力学及代谢研究
Jiang Pu,Jinsong He,Ru Xue et al.
Jiang Pu et al.
Background and purpose: Ketoconazole is limited to its conditioned oral use due to hepatic toxicity. Its ocular eye drop administration may be an option for mycotic keratitis treatment. Therefore, it is necessary to explo...
Meiske Naomi Mamuaja,Tati Herlina,Rymond Jusuf Rumampuk et al.
Meiske Naomi Mamuaja et al.
Background and purpose: Many studies have been performed to identify new sources, their optimal isolation, and the biological activities of flavonoids due to nutraceutical, pharmaceutical, and cosmeceutical properties. ...
Combined approach of nanoemulgel and microneedle pre-treatment as a topical anticellulite therapy [0.03%]
纳米乳凝胶与微针联合治疗局部抗橘皮症疗法
Hiba Imad Hameed,Mohammed Hussain Al-Mayahy
Hiba Imad Hameed
Background and purpose: Cellulite is caused by changes in the metabolism of the fatty tissue beneath the skin. Methylxanthines and retinoids are commonly added to the different anticellulite products. However, their topic...