Two-dimensional Co-based metal-organic framework nanosheets as an efficient electrochemical sensing platform for simultaneous determination of daunorubicin and idarubicin [0.03%]
二维Co基金属有机框架纳米片作为高效的电化学传感平台同时检测多柔比星和伊达比星
Somayeh Tajik,Erfan Beiromi,Hadi Beitollahi et al.
Somayeh Tajik et al.
Background and purpose: Chemotherapy is the most effective and commonly utilized cancer treatment method. Therefore, studies on the sensitive determination of chemotherapy drugs used in cancer treatment can be very effect...
Voltammetric determination of sumatriptan in the presence of naproxen using a modified screen printed electrode [0.03%]
改良型屏幕印刷电极在纳普洛斯存在下 voltammetric 定量 sumatriptan 的含量
Hazim Saad Jabbar Al-Maliki,Sudad Jasim Mohammed,Adil Turki Al-Musawi et al.
Hazim Saad Jabbar Al-Maliki et al.
Background and purpose: Sumatriptan is used to alleviate symptoms of migraine headaches, particularly during acute attacks. Naproxen is a medication that provides relief from pain, inflammation, and fever. Therefore, dete...
Electrochemical sensor based on multi-walled carbon nanotubes and two-dimensional zeolitic imidazolate framework nanosheets: Application in determining dacarbazine [0.03%]
基于多壁碳纳米管和二维沸石咪唑骨架纳米片的电化学传感器：用于达卡巴嗪的测定
Somayeh Tajik,Hadi Beitollahi,Fariba Garkani Nejad et al.
Somayeh Tajik et al.
Background and purpose: Cancer is a serious public health concern, hence the determination of dacarbazine as a significant chemotherapeutic agent is very important. ...
Gold nanoparticle-modified screen-printed carbon electrodes for label-free detection of SARS-CoV-2 RNA using drop casting and spray coating methods [0.03%]
用于SARS-CoV-2 RNA无标记检测的金纳米粒子修饰的屏幕打印碳电极滴涂和喷涂法
Salma Nur Zakiyyah,Nadya Putri Satriana,Natasha Fransisca et al.
Salma Nur Zakiyyah et al.
Background and purpose: This study aimed to explore the modification of screen-printed carbon electrode (SPCE) to produce an extensive conductive surface with gold nanoparticles (AuNPs) for the detection of severe acute r...
Effect of bicarbonate buffer on artificial membrane permeation of drugs [0.03%]
碳酸氢盐缓冲溶液对药物透过人工膜渗透的影响
Shiori Ishida,Samuel Lee,Balint Sinko et al.
Shiori Ishida et al.
Background and purpose: The pH value of the small intestine is physiologically maintained by bicarbonate buffer (BCB). However, the effect of BCB on the membrane permeation of drugs has not been investigated. The purpose ...
Naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats [0.03%]
奈林在糖尿病心肌病过程中防止心脏线粒体功能障碍的能力研究
Ilya B Zavodnik,Tatsiana A Kavalenia,Siarhei N Kirko et al.
Ilya B Zavodnik et al.
Background and purpose: Cardiac mitochondria dysfunction plays a central pathophysiological role in the abnormal glucose metabolism in the heart during diabetic cardiomyopathy. The present study evaluated the effects of f...
Often neglected steps in transforming drug solubility from single measurement in pure water to physiologically-appropriate solubility-pH [0.03%]
从纯水中的单一测量到生理上合适的溶解度- pH转换中经常被忽略的步骤
Alex Avdeef
Alex Avdeef
Background and purpose: The solubility of weakly-ionizable drugs in pure water, Sw, is commonly measured. The pH-dependent properties of the saturated solutions can be surprisingly complex in subtle ways. This commentary ...
Antimicrobial and ADME properties of methoxylated, methylated and nitrated 2-hydroxynaphthalene-1 carboxanilides [0.03%]
含有甲氧基、甲基和硝基的2-羟基萘-1-羧酸酰胺的抗菌性及ADME性质研究
Lucia Vrablova,Tomas Gonec,Tereza Kauerova et al.
Lucia Vrablova et al.
Background and purpose: Many new compounds are being prepared to overcome the problem of increasing microbial resistance and the increasing number of infections. ...
Natural polymer derivative-based pH-responsive nanoformulations with entrapped diketo-tautomers of 5-fluorouracil for enhanced cancer therapy [0.03%]
基于天然聚合物衍生物的pH响应型纳米制剂，内含5-氟尿嘧啶的二酮互变异构体，用于增强癌症治疗
Anbazhagan Thirumalai,Koyeli Girigoswami,Karthick Harini et al.
Anbazhagan Thirumalai et al.
Background and purpose: Despite significant advancements in cancer therapies, chemotherapeutics continue to be the mainstay for treating cancer patients, with 5-fluorouracil (5-FU) being commonly used for various cancers....
Microwave coprocessing of modafinil with Gelucire®: Thermal and compression characteristics [0.03%]
莫达非尼与Gelucire®的微波共处理：热特性和压缩特性
Derar Omari,Assayed Sallam,Iyad Rashid et al.
Derar Omari et al.
Introduction: Modafinil, a wakefulness-promoting agent, is primarily used to treat excessive daytime sleepiness associated with narcolepsy and fatigue. As a BCS class II drug, modafinil exhibits low solubility and high pe...