Simultaneous determination of epinephrine and folic acid using MIL-101 (Fe)-NH2 metal-organic framework/graphene oxide nanocomposite modified electrode [0.03%]
用于同时测定肾上腺素和叶酸的MIL-101（Fe）-NH2金属有机骨架/氧化石墨烯纳米复合材料修饰电极
Rasha Kareem Khundhur
Rasha Kareem Khundhur
Background and purpose: It is generally known that the majority of disorders exhibit symptoms to some degree when the quantities of two crucial substances, epinephrine and folic acid, are low or high. These two chemicals'...
Leveraging machine learning models in evaluating ADMET properties for drug discovery and development [0.03%]
机器学习模型在药物研发过程中的ADMET属性评估中的应用研究进展
Magesh Venkataraman,Gopi Chand Rao,Jeevan Karthik Madavareddi et al.
Magesh Venkataraman et al.
Background and purpose: The evaluation of ADMET properties remains a critical bottleneck in drug discovery and development, contributing significantly to the high attrition rate of drug candidates. Traditional experimenta...
Tuneable carbon dots coated iron oxide nanoparticles as superior T 1 contrast agent for multimodal imaging [0.03%]
一种新型的用于多模态医学影像的磁共振成像T1对比剂：包覆了铁氧化物的可调式碳点
Anbazhagan Thirumalai,Palani Sharmiladevi,Koyeli Girigoswami et al.
Anbazhagan Thirumalai et al.
Background and purpose: Multifunctional hybrid nanoparticles garner heightened interest for prospective biomedical applications, including medical imaging and medication administration, owing to their synergistic benefits...
CRISPR-Cas9-based electrochemical biosensor for the detection of katG gene mutations in isoniazid-resistant tuberculosis [0.03%]
基于CRISPR-Cas9的电化学生物传感器检测异烟肼耐药结核分枝杆菌katG基因变异
Dika Apriliana Wulandari,Muhammad Ihda Hamlu Liwaissunati Zein,Salma Nur Zakiyyah et al.
Dika Apriliana Wulandari et al.
Background and purpose: Multidrug-resistant tuberculosis (MDR-TB) remains a significant challenge in tuberculosis (TB) treatment, driven by simultaneous mutations in the rpoB and katG genes that confer resistance to rifam...
Preclinical pharmacokinetics, distribution, metabolism and excretion of disitamab vedotin [0.03%]
迪欣单抗- vedotin 的药代动力学、分布、代谢和排泄的临床前研究
Ling Wang,Limeng Zhu,Fengzhu Wang et al.
Ling Wang et al.
Background and purpose: Disitamab vedotin is an antibody-drug conjugate (ADC) composed of a humanized IgG1 monoclonal antibody (mAb) targeting HER2 conjugated to monomethyl auristatin E(MMAE) via a cleavable dipeptide lin...
Chitosan-modified ceftazidime loaded polyhydroxyalkanoates microparticles: preparation, characterization and antibacterial evaluation in vitro [0.03%]
壳聚糖修饰的载头孢他啶聚羟基烷酸酯微粒的制备、表征及体外抗菌评价
Anastasiya Murueva,Natalia Zhila,Alexey Dudaev et al.
Anastasiya Murueva et al.
Background and purpose: The use of drug delivery systems to enhance the efficacy of existing antimicrobial drugs is one of the promising approaches to combat bacterial resistance. The simultaneous presence of a polycation...
A new method for measuring dopamine in the presence of uric acid employing a carbon paste electrode modified with the UiO-66 metal organic framework-graphene oxide nanocomposite [0.03%]
一种新方法采用UiO-66金属有机骨架-石墨烯氧化纳米复合材料修饰的碳糊电极测定尿酸存在下多巴胺的含量
Azhar Hameed Gatea,Aseer Shakir Ajel,Raed Muslim Mhaibes
Azhar Hameed Gatea
Background and purpose: Dopamine has an impact on the cardiovascular, endocrine, renal, and central neurological systems. Electrochemical techniques are becoming more and more popular among researchers as a way to assess ...
Curcumin-loaded nanoemulsion for acute lung injury treatment via nebulization: Formulation, optimization and in vivo studies [0.03%]
纳米乳液载姜黄素用于急性肺损伤治疗：雾化吸入给药配方、优化及体内实验研究
Prashant Anilkumar Singh,Rajendra Awasthi,Ramendra Pati Pandey et al.
Prashant Anilkumar Singh et al.
Introduction: Curcumin, a polyphenolic bioactive molecule, exhibits potent anti-inflammatory and antioxidant properties by reducing cytokine levels such as IL-6, TNF-α, and TGF-β. It regulates IL-17A and modulates key s...
Management of intraocular pressure and inflammation using febuxostat film: in vitro - in vivo correlation [0.03%]
非布司他眼用薄膜对眼内压及炎症的管理：体外-体内相关性研究
Mouli Das,Sk Habibullah,Tanisha Das et al.
Mouli Das et al.
Background and purpose: Urate crystal accumulation may lead to the condition of ocular tophaceous gout, causing ocular inflammation and increased intraocular pressure (IOP) due to the triggering of several inflammatory re...
Insight into antistaphylococcal effect of chlorinated 1-hydroxynaphthalene-2-carboxanilides [0.03%]
氯化1-羟基萘-2-甲酰胺衍生物的抗金黄色葡萄球菌作用机制研究
Lucia Vrablova,Tomas Gonec,Petra Majerova et al.
Lucia Vrablova et al.
Background and purpose: New compounds and innovative therapeutic approaches are trying to prevent antimicrobial resistance, which has become a global health challenge. ...